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词条 Tolaasin
释义

  1. References

{{Technical|date=April 2016}}Tolaasin, a toxic secretion by Pseudomonas tolaasii, is the cause of bacterial brown blotch disease of edible mushrooms.[1] Tolaasin is a 1985 Da lipodepsipeptide non-host specific toxin. In addition to forming an amphipathic left handed alpha-helix in a hydrophobic environment, the toxin has been shown to form Zn2+-sensitive voltage-gated ion channels in planar lipid bilayers and to catalyze erythrocyte lysis by a colloid osmotic mechanism.[2] At high concentrations, tolaasin acts as a detergent that is able to directly dissolve eukaryotic membranes.[1]

References

1. ^{{cite journal| journal=Physiol. Molec. Pl. Pathol|volume = 42|issue = 6|year=1993 |pages=373–384 |title= Evidence for the involvement of the surface active properties of the extracellular toxin tolaasin in the manifestation of brown blotch disease symptoms by Pseudomonas tolaasii on Agaricus bisporus |author1=Hutchison, M. L. |author2=Johnstone, K. J. |url = http://www.sciencedirect.com/science/article/pii/S088557650580013X |doi=10.1016/S0885-5765(05)80013-X}}
2. ^{{cite journal| journal=Physiol. Molec. Pl. Pathol|volume = 39|issue = 1|year=1991 |pages=57–70 |title= Biological properties and spectrum of activity of tolaasin, a lipodepsipeptide toxin produced by the mushroom pathogen Pseudomonas tolaasii. on Agaricus bisporus |author1=Rainey, P. B. |author2=Brodey, C. L. |author3=Johnstone, K. J. |url = http://www.sciencedirect.com/science/article/pii/088557659190031C |doi=10.1016/0885-5765(91)90031-C}}
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2 : Peptides|Bacterial toxins
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