| 词条 | Tolufazepam |
| 释义 |
}}{{Drugbox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 451549928 | IUPAC_name = 7-chloro-5-(2-chlorophenyl)-1-[2-(4-methylphenyl)sulfonylethyl]-3H-1,4-benzodiazepin-2-one | image = Tolufazepam.svg | width = 180 | tradename = | legal_status = | bioavailability = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 86273-92-9 | PubChem = 65647 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 98SR74X50D | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 59084 | C=24 | H=20 | Cl=2 | N=2 | O=3 | S=1 | molecular_weight = 487.397 g/mol | smiles = Clc2ccccc2C(=NCC1=O)c3cc(Cl)ccc3N1CCS(=O)(=O)c(cc4)ccc4C | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C24H20Cl2N2O3S/c1-16-6-9-18(10-7-16)32(30,31)13-12-28-22-11-8-17(25)14-20(22)24(27-15-23(28)29)19-4-2-3-5-21(19)26/h2-11,14H,12-13,15H2,1H3 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = FFZOBTGTWSRRMB-UHFFFAOYSA-N }}Tolufazepam is a drug that is a benzodiazepine derivative.[1] Studies have shown tolufazepam to have anticonvulsant and anxiolytic activity in animal subjects,[2] including convulsions elicited by pentylenetetrazol.[3] See also
References1. ^{{Cite journal |author= |title=LIST OF INTERNATIONAL NON-PROPRIETARY NAMES (INNS), PROVIDED FOR PHARMACEUTICAL SUBSTANCES BY THE WORLD HEALTH ORGANIZATION, WHICH ARE FREE OF DUTY |journal=Official Journal of the European Communities |format=PDF |date=23 October 2001 |accessdate=7 December 2009 |url=http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2001:279:0767:0876:EN:PDF |archive-url=https://archive.is/20140627223035/http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2001:279:0767:0876:EN:PDF |dead-url=yes |archive-date=27 June 2014 }} {{Benzodiazepines}}{{GABAAR PAMs}}{{sedative-stub}}2. ^{{Cite book|title=Chapter 2. Antianxiety Agents and Anticonvulsants|volume = 24|last=Hrib|first=Nicholas J.|last2=Martin|first2=Lawrence L.|pages=11–20|doi=10.1016/s0065-7743(08)60524-2|series = Annual Reports in Medicinal Chemistry|year = 1989|isbn = 9780120405244}} 3. ^{{Cite journal|last=Pérez|first=C.|last2=Mondelo|first2=N.|last3=Stéfano|first3=F. J.|last4=Lores Arnaiz|first4=J.|date=May 1988|title=Pharmacological activity of novel alkylsulfonylaryl-1-substituted-1,4-benzodiazepine derivatives|journal=Archives Internationales de Pharmacodynamie et de Therapie|volume=293|pages=57–68|issn=0003-9780|pmid=2901826}} 5 : Benzodiazepines|Chloroarenes|GABAA receptor positive allosteric modulators|Lactams|Sulfones |
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