| 词条 | Touton giant cell |
| 释义 |
HistoryTouton giant cells are named for Karl Touton, a German botanist and dermatologist.[2] Karl Touton first observed these cells in 1885 and named them "xanthelasmatic giant cells", a name which has since fallen out of favor.[3] AppearanceTouton giant cells, being multinucleated giant cells, can be distinguished by the presence of several nuclei in a distinct pattern. They contain a ring of nuclei surrounding a central homogeneous cytoplasm, while foamy cytoplasm surrounds the nuclei.[4][5] The cytoplasm surrounded by the nuclei has been described as both amphophilic and eosinophilic, while the cytoplasm near the periphery of the cell is pale and foamy in appearance.[6] CausesTouton giant cells are formed by the fusion of macrophage-derived foam cells. It has been suggested that cytokines such as interferon gamma, interleukin-3, and M-CSF may be involved in the production of Touton giant cells.[7][8] References1. ^{{cite book |author1=Rapini, Ronald P. |author2=Bolognia, Jean L. |author3=Jorizzo, Joseph L. |title=Dermatology: 2-Volume Set |publisher=Mosby |location=St. Louis |year=2007 |pages=14, 15 |isbn=978-1-4160-2999-1 |oclc= |doi= |accessdate=}} 2. ^{{Cite journal | pmid = 3068999 | date=Jun 1988 | title = Karl Touton and his "xanthelasmatic giant cell." A selective review of multinucleated giant cells | volume = 10| last1 = Aterman | first3 = M. | issue = 3 | last3 = Smith | pages = 257–269| issn = 0193-1091 | first1 = K. | journal = The American Journal of Dermatopathology| last2 = Remmele | first2 = W.}} 3. ^{{cite book |last=Olson |first=James |title=The History of Cancer: An Annotated Bibliography |publisher=ABC-CLIO |year=1989 |pages=139 |isbn=9780313258893}} 4. ^{{cite book | last = Grant-Kels | first = Jane | title = Color Atlas of Dermatopathology | publisher = Informa Healthcare | location = City | year = 2007 | isbn = 978-0-8493-3794-9 | pages = 107, 119 }} 5. ^{{cite journal |last1=Carmen Gómez-Mateo |first1=Maria |last2=Monteagudo |first2=Carlos |date=2013 |title=Nonepithelial skin tumors with multinucleated giant cells |url=http://www.semdiagpath.com/article/S0740-2570(12)00009-3/fulltext |journal=Seminars in Diagnostic Pathology |volume=30 |issue=1 |pages=58–72 |pmid=23327730 |doi=10.1053/j.semdp.2012.01.004}} 6. ^{{cite journal |last1=Sequeira |first1=Fiona |last2=Gandhi |first2=Suneil |date=2012 |title=Named cells in dermatology |url=http://www.ijdvl.com/article.asp?issn=0378-6323;year=2012;volume=78;issue=2;spage=207;epage=216;aulast=Sequeira |journal=Indian Journal of Dermatology, Venereology and Leprology |volume=78 |issue=2 |pages=207–16 |doi=10.4103/0378-6323.93650 |pmid=22421663}} 7. ^{{cite journal |last1=Quinn |first1=Mark |last2=Schepetkin |first2=Igor |date=2009 |title=Role of NADPH Oxidase in Formation and Function of Multinucleated Giant Cells |journal=Journal of Innate Immunology |volume=1 |issue=6 |pages=509–26 |doi=10.1159/000228158 |pmc=2919507 |pmid=20375608}} 8. ^{{cite journal |last1=Reiss |first1=AB |last2=Patel |first2=CA |date=2004 |title=Interferon-gamma impedes reverse cholesterol transport and promotes foam cell transformation in THP-1 human monocytes/macrophages |journal=Medical Science Monitor |volume=10 |issue=11 |pages=420–5 |pmid=15507847}} External links
1 : Cell biology |
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