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词条 TPD52L1
释义

  1. Function

  2. Interactions

  3. References

  4. Further reading

{{Infobox_gene}}Tumor protein D53 is a protein that in humans is encoded by the TPD52L1 gene.[1][2][3]

Function

This gene encodes a member of the tumor protein D52 (TPD52) family. The encoded protein contains a coiled-coil domain and may form homo- or hetero-dimer with TPD52 family members. The protein is reported to be involved in cell proliferation and calcium signaling. It also interacts with the mitogen-activated protein kinase kinase kinase 5 (MAP3K5/ASK1) and positively regulates MAP3K5-induced apoptosis. Multiple alternatively spliced transcript variants have been observed, but the full-length nature of some variants has not yet been determined.[3]

Interactions

TPD52L1 has been shown to interact with TPD52L2[4] and TPD52.[4]

References

1. ^{{cite journal | vauthors = Byrne JA, Mattei MG, Basset P | title = Definition of the tumor protein D52 (TPD52) gene family through cloning of D52 homologues in human (hD53) and mouse (mD52) | journal = Genomics | volume = 35 | issue = 3 | pages = 523–32 | date = Dec 1996 | pmid = 8812487 | pmc = | doi = 10.1006/geno.1996.0393 }}
2. ^{{cite journal | vauthors = Boutros R, Byrne JA | title = D53 (TPD52L1) is a cell cycle-regulated protein maximally expressed at the G2-M transition in breast cancer cells | journal = Exp. Cell Res. | volume = 310 | issue = 1 | pages = 152–65 | date = Oct 2005 | pmid = 16112108 | pmc = | doi = 10.1016/j.yexcr.2005.07.009 }}
3. ^{{cite web | title = Entrez Gene: TPD52L1 tumor protein D52-like 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7164| accessdate = }}
4. ^{{cite journal | vauthors = Byrne JA, Nourse CR, Basset P, Gunning P | title = Identification of homo- and heteromeric interactions between members of the breast carcinoma-associated D52 protein family using the yeast two-hybrid system | journal = Oncogene | volume = 16 | issue = 7 | pages = 873–81 | date = Feb 1998 | pmid = 9484778 | doi = 10.1038/sj.onc.1201604 }}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Byrne JA, Tomasetto C, Garnier JM, Rouyer N, Mattei MG, Bellocq JP, Rio MC, Basset P | title = A screening method to identify genes commonly overexpressed in carcinomas and the identification of a novel complementary DNA sequence | journal = Cancer Res. | volume = 55 | issue = 13 | pages = 2896–903 | year = 1995 | pmid = 7796418 | doi = }}
  • {{cite journal | vauthors = Byrne JA, Nourse CR, Basset P, Gunning P | title = Identification of homo- and heteromeric interactions between members of the breast carcinoma-associated D52 protein family using the yeast two-hybrid system | journal = Oncogene | volume = 16 | issue = 7 | pages = 873–81 | year = 1998 | pmid = 9484778 | doi = 10.1038/sj.onc.1201604 }}
  • {{cite journal | vauthors = Byrne JA, Mattei MG, Basset P, Gunning P | title = Identification and in situ hybridization mapping of a mouse Tpd52l1 (D53) orthologue to chromosome 10A4-B2 | journal = Cytogenet. Cell Genet. | volume = 81 | issue = 3-4 | pages = 199–201 | year = 1998 | pmid = 9730602 | doi = 10.1159/000015029 }}
  • {{cite journal | vauthors = Wilson SH, Bailey AM, Nourse CR, Mattei MG, Byrne JA | title = Identification of MAL2, a novel member of the mal proteolipid family, though interactions with TPD52-like proteins in the yeast two-hybrid system | journal = Genomics | volume = 76 | issue = 1-3 | pages = 81–8 | year = 2001 | pmid = 11549320 | doi = 10.1006/geno.2001.6610 }}
  • {{cite journal | vauthors = Sathasivam P, Bailey AM, Crossley M, Byrne JA | title = The role of the coiled-coil motif in interactions mediated by TPD52 | journal = Biochem. Biophys. Res. Commun. | volume = 288 | issue = 1 | pages = 56–61 | year = 2001 | pmid = 11594751 | doi = 10.1006/bbrc.2001.5721 }}
  • {{cite journal | vauthors = Boutros R, Bailey AM, Wilson SH, Byrne JA | title = Alternative splicing as a mechanism for regulating 14-3-3 binding: interactions between hD53 (TPD52L1) and 14-3-3 proteins | journal = J. Mol. Biol. | volume = 332 | issue = 3 | pages = 675–87 | year = 2003 | pmid = 12963375 | doi = 10.1016/S0022-2836(03)00944-6 }}
  • {{cite journal | vauthors = Cho S, Ko HM, Kim JM, Lee JA, Park JE, Jang MS, Park SG, Lee DH, Ryu SE, Park BC | title = Positive regulation of apoptosis signal-regulating kinase 1 by hD53L1 | journal = J. Biol. Chem. | volume = 279 | issue = 16 | pages = 16050–6 | year = 2004 | pmid = 14761963 | doi = 10.1074/jbc.M305758200 }}
  • {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
  • {{cite journal | vauthors = Barbaric D, Byth K, Dalla-Pozza L, Byrne JA | title = Expression of tumor protein D52-like genes in childhood leukemia at diagnosis: clinical and sample considerations | journal = Leuk. Res. | volume = 30 | issue = 11 | pages = 1355–63 | year = 2006 | pmid = 16620967 | doi = 10.1016/j.leukres.2006.03.009 }}
  • {{cite journal | vauthors = Cao Q, Chen J, Zhu L, Liu Y, Zhou Z, Sha J, Wang S, Li J | title = A testis-specific and testis developmentally regulated tumor protein D52 (TPD52)-like protein TPD52L3/hD55 interacts with TPD52 family proteins | journal = Biochem. Biophys. Res. Commun. | volume = 344 | issue = 3 | pages = 798–806 | year = 2006 | pmid = 16631610 | doi = 10.1016/j.bbrc.2006.03.208 }}
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