| 释义 |
- References
- Further reading
{{Infobox_gene}}Tubulin polymerization-promoting protein is a protein that in humans is encoded by the TPPP gene.[1][2][3][4][5]This protein has been linked to multiple sclerosis myelin lesions and CSF abnormalities in multiple sclerosis patients.[6] This has also been linked to Parkinson's and Alzheimer's Disease[7][8] References1. ^{{cite journal | vauthors = Seki N, Hattori A, Sugano S, Suzuki Y, Nakagawara A, Muramatsu M, Hori T, Saito T | title = A novel human gene whose product shares significant homology with the bovine brain-specific protein p25 on chromosome 5p15.3 | journal = J Hum Genet | volume = 44 | issue = 2 | pages = 121–2 |date=Apr 1999 | pmid = 10083737 | pmc = | doi = 10.1007/s100380050122 }}
2. ^{{cite journal | vauthors = Hlavanda E, Kovacs J, Olah J, Orosz F, Medzihradszky KF, Ovadi J | title = Brain-specific p25 protein binds to tubulin and microtubules and induces aberrant microtubule assemblies at substoichiometric concentrations | journal = Biochemistry | volume = 41 | issue = 27 | pages = 8657–64 |date=Jul 2002 | pmid = 12093283 | pmc = | doi =10.1021/bi020140g }}
3. ^{{cite journal | vauthors = Lindersson E, Lundvig D, Petersen C, Madsen P, Nyengaard JR, Hojrup P, Moos T, Otzen D, Gai WP, Blumbergs PC, Jensen PH | title = p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies | journal = J Biol Chem | volume = 280 | issue = 7 | pages = 5703–15 |date=Feb 2005 | pmid = 15590652 | pmc = | doi = 10.1074/jbc.M410409200 }}
4. ^{{cite journal | vauthors = Vincze O, Tokesi N, Olah J, Hlavanda E, Zotter A, Horvath I, Lehotzky A, Tirian L, Medzihradszky KF, Kovacs J, Orosz F, Ovadi J | title = Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions | journal = Biochemistry | volume = 45 | issue = 46 | pages = 13818–26 |date=Nov 2006 | pmid = 17105200 | pmc = | doi = 10.1021/bi061305e }}
5. ^{{cite web | title = Entrez Gene: TPPP brain-specific protein p25 alpha| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11076| accessdate = }}
6. ^{{cite journal | vauthors = Vincze O, Oláh J, Zádori D, Klivényi P, Vécsei L, Ovádi J | title = A new myelin protein, TPPP/p25, reduced in demyelinated lesions is enriched in cerebrospinal fluid of multiple sclerosis | journal = Biochem. Biophys. Res. Commun. | volume = 409 | issue = 1 | pages = 137–41 |date=May 2011 | pmid = 21565174 | doi = 10.1016/j.bbrc.2011.04.130 }}
7. ^{{Cite journal|last=Kovács|first=Gábor G.|last2=László|first2=Lajos|last3=Kovács|first3=János|last4=Jensen|first4=Poul Henning|last5=Lindersson|first5=Evo|last6=Botond|first6=Gergő|last7=Molnár|first7=Tamás|last8=Perczel|first8=András|last9=Hudecz|first9=Ferenc|date=2004-11-01|title=Natively unfolded tubulin polymerization promoting protein TPPP/p25 is a common marker of alpha-synucleinopathies|url=http://www.sciencedirect.com/science/article/pii/S0969996104001366|journal=Neurobiology of Disease|volume=17|issue=2|pages=155–162|doi=10.1016/j.nbd.2004.06.006|pmid=15474353|access-date=|via=}}
8. ^{{Cite journal|last=Kovács|first=Gábor G.|last2=Gelpi|first2=Ellen|last3=Lehotzky|first3=Attila|last4=Höftberger|first4=Romana|last5=Erdei|first5=Anna|last6=Budka|first6=Herbert|last7=Ovádi|first7=Judit|date=2006-11-23|title=The brain-specific protein TPPP/p25 in pathological protein deposits of neurodegenerative diseases|journal=Acta Neuropathologica|language=en|volume=113|issue=2|pages=153–161|doi=10.1007/s00401-006-0167-4|issn=0001-6322|pmid=17123092}}
Further reading{{refbegin | 2}}- {{cite journal | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
- {{cite journal | vauthors=Martín CP, Vázquez J, Avila J, Moreno FJ |title=P24, a glycogen synthase kinase 3 (GSK 3) inhibitor. |journal=Biochim. Biophys. Acta |volume=1586 |issue= 1 |pages= 113–22 |year= 2002 |pmid= 11781156 |doi= 10.1016/s0925-4439(01)00092-8 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Tirián L, Hlavanda E, Oláh J, etal |title=TPPP/p25 promotes tubulin assemblies and blocks mitotic spindle formation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 24 |pages= 13976–81 |year= 2004 |pmid= 14623963 |doi= 10.1073/pnas.2436331100 | pmc=283531 }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Lehotzky A, Tirián L, Tökési N, etal |title=Dynamic targeting of microtubules by TPPP/p25 affects cell survival. |journal=J. Cell Sci. |volume=117 |issue= Pt 25 |pages= 6249–59 |year= 2005 |pmid= 15564385 |doi= 10.1242/jcs.01550 }}
- {{cite journal |vauthors=DeGiorgis JA, Jaffe H, Moreira JE, etal |title=Phosphoproteomic analysis of synaptosomes from human cerebral cortex. |journal=J. Proteome Res. |volume=4 |issue= 2 |pages= 306–15 |year= 2005 |pmid= 15822905 |doi= 10.1021/pr0498436 }}
- {{cite journal |vauthors=Jämsä A, Bäckström A, Gustafsson E, etal |title=Glutamate treatment and p25 transfection increase Cdk5 mediated tau phosphorylation in SH-SY5Y cells. |journal=Biochem. Biophys. Res. Commun. |volume=345 |issue= 1 |pages= 324–31 |year= 2006 |pmid= 16678793 |doi= 10.1016/j.bbrc.2006.04.032 }}
- {{cite journal | vauthors=Skjoerringe T, Lundvig DM, Jensen PH, Moos T |title=P25alpha/Tubulin polymerization promoting protein expression by myelinating oligodendrocytes of the developing rat brain. |journal=J. Neurochem. |volume=99 |issue= 1 |pages= 333–42 |year= 2006 |pmid= 16879710 |doi= 10.1111/j.1471-4159.2006.04073.x }}
- {{cite journal |vauthors=Oláh J, Tokési N, Vincze O, etal |title=Interaction of TPPP/p25 protein with glyceraldehyde-3-phosphate dehydrogenase and their co-localization in Lewy bodies. |journal=FEBS Lett. |volume=580 |issue= 25 |pages= 5807–14 |year= 2006 |pmid= 17027006 |doi= 10.1016/j.febslet.2006.09.037 }}
- {{cite journal |vauthors=Hlavanda E, Klement E, Kókai E, etal |title=Phosphorylation blocks the activity of tubulin polymerization-promoting protein (TPPP): identification of sites targeted by different kinases. |journal=J. Biol. Chem. |volume=282 |issue= 40 |pages= 29531–9 |year= 2007 |pmid= 17693641 |doi= 10.1074/jbc.M703466200 }}
- {{cite journal |vauthors=Song YJ, Lundvig DM, Huang Y, etal |title=p25alpha relocalizes in oligodendroglia from myelin to cytoplasmic inclusions in multiple system atrophy. |journal=Am. J. Pathol. |volume=171 |issue= 4 |pages= 1291–303 |year= 2007 |pmid= 17823288 |doi= 10.2353/ajpath.2007.070201 | pmc=1988878 }}
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