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词条 TRAF4
释义

  1. Protein interactions

  2. References

  3. Further reading

{{Infobox_gene}}TNF receptor-associated factor 4 (TRAF4) also known as RING finger protein 83 (RNF83) is a protein that in humans is encoded by the TRAF4 gene.[1][2][3]

TRAF4 is a member of the TNF receptor associated factor (TRAF) family, a family of scaffold proteins.[4] TRAF proteins connect IL-1R/Toll and TNF receptors with signaling factors that lead to the activation of NF-κB and mitogen-activated protein kinases. However, TRAF4 is not known to interact with TNF receptors and its cellular functions are not well understood.[5]

Protein interactions

TRAF4 has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1),[6][7] and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined.[3]

A recent report indicates that TRAF4 binds to NOD-Like Receptors NOD1 and NOD2, and specifically inhibits activation of NF-κB by the activated NOD2-RIP2 complex [8]

References

1. ^{{cite journal | vauthors = Regnier CH, Tomasetto C, Moog-Lutz C, Chenard MP, Wendling C, Basset P, Rio MC | title = Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma | journal = J Biol Chem | volume = 270 | issue = 43 | pages = 25715–21 |date=Dec 1995 | pmid = 7592751 | pmc = | doi =10.1074/jbc.270.43.25715 }}
2. ^{{cite journal | vauthors = Tomasetto C, Regnier C, Moog-Lutz C, Mattei MG, Chenard MP, Lidereau R, Basset P, Rio MC | title = Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17 | journal = Genomics | volume = 28 | issue = 3 | pages = 367–76 |date=Jan 1996 | pmid = 7490069 | pmc = | doi = 10.1006/geno.1995.1163 }}
3. ^1 {{cite web | title = Entrez Gene: TRAF4 TNF receptor-associated factor 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9618| accessdate = }}
4. ^{{cite journal | vauthors = Wajant H, Henkler F, Scheurich P | title = The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators | journal = Cell. Signal. | volume = 13 | issue = 6 | pages = 389–400 |date=June 2001 | pmid = 11384837 | doi = 10.1016/S0898-6568(01)00160-7| url = }}
5. ^{{cite journal | vauthors = Kedinger V, Rio MC | title = TRAF4, the unique family member | journal = Adv. Exp. Med. Biol. | volume = 597 | issue = | pages = 60–71 | year = 2007 | pmid = 17633017 | doi = 10.1007/978-0-387-70630-6_5 | url = | series = Advances in Experimental Medicine and Biology | isbn = 978-0-387-70629-0 }}
6. ^{{cite journal | vauthors = Ye X, Mehlen P, Rabizadeh S, VanArsdale T, Zhang H, Shin H, Wang JJ, Leo E, Zapata J, Hauser CA, Reed JC, Bredesen DE | title = TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction | journal = J. Biol. Chem. | volume = 274 | issue = 42 | pages = 30202–8 |date=October 1999 | pmid = 10514511 | doi = 10.1074/jbc.274.42.30202| url = }}
7. ^{{cite journal | vauthors = Krajewska M, Krajewski S, Zapata JM, Van Arsdale T, Gascoyne RD, Berern K, McFadden D, Shabaik A, Hugh J, Reynolds A, Clevenger CV, Reed JC | title = TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues | journal = Am. J. Pathol. | volume = 152 | issue = 6 | pages = 1549–61 |date=June 1998 | pmid = 9626059 | pmc = 1858434 | doi = | url = }}
8. ^{{cite journal | vauthors = Marinis JM, Homer CR, McDonald C, Abbott DW | title = A Novel Motif in the Crohn's Disease Susceptibility Protein, NOD2, Allows TRAF4 to Down-regulate Innate Immune Responses | journal = J. Biol. Chem. | volume = 286 | pages = 1938–1950 | year = 2011 | pmid = 21097508 | doi = 10.1074/jbc.M110.189308 | issue = 3 | pmc = 3023490}}
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Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors=Bradley JR, Pober JS |title=Tumor necrosis factor receptor-associated factors (TRAFs) |journal=Oncogene |volume=20 |issue= 44 |pages= 6482–91 |year= 2001 |pmid= 11607847 |doi= 10.1038/sj.onc.1204788 }}
  • {{cite journal |vauthors=Masson R, Régnier CH, Chenard MP, etal |title=Tumor necrosis factor receptor associated factor 4 (TRAF4) expression pattern during mouse development |journal=Mech. Dev. |volume=71 |issue= 1–2 |pages= 187–91 |year= 1998 |pmid= 9507120 |doi=10.1016/S0925-4773(97)00192-5 }}
  • {{cite journal |vauthors=Zapata JM, Pawlowski K, Haas E, etal |title=A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 24242–52 |year= 2001 |pmid= 11279055 |doi= 10.1074/jbc.M100354200 }}
  • {{cite journal |vauthors=Régnier CH, Masson R, Kedinger V, etal |title=Impaired neural tube closure, axial skeleton malformations, and tracheal ring disruption in TRAF4-deficient mice |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 8 |pages= 5585–90 |year= 2002 |pmid= 11943846 |doi= 10.1073/pnas.052124799 | pmc=122813 }}
  • {{cite journal |vauthors=Xu YC, Wu RF, Gu Y, etal |title=Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase |journal=J. Biol. Chem. |volume=277 |issue= 31 |pages= 28051–7 |year= 2002 |pmid= 12023963 |doi= 10.1074/jbc.M202665200 }}
  • {{cite journal |vauthors=Glauner H, Siegmund D, Motejadded H, etal |title=Intracellular localization and transcriptional regulation of tumor necrosis factor (TNF) receptor-associated factor 4 (TRAF4) |journal=Eur. J. Biochem. |volume=269 |issue= 19 |pages= 4819–29 |year= 2002 |pmid= 12354113 |doi=10.1046/j.1432-1033.2002.03180.x }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
  • {{cite journal | vauthors=Sax JK, El-Deiry WS |title=Identification and characterization of the cytoplasmic protein TRAF4 as a p53-regulated proapoptotic gene |journal=J. Biol. Chem. |volume=278 |issue= 38 |pages= 36435–44 |year= 2003 |pmid= 12788948 |doi= 10.1074/jbc.M303191200 }}
  • {{cite journal | vauthors=Fleckenstein DS, Dirks WG, Drexler HG, Quentmeier H |title=Tumor necrosis factor receptor-associated factor (TRAF) 4 is a new binding partner for the p70S6 serine/threonine kinase |journal=Leuk. Res. |volume=27 |issue= 8 |pages= 687–94 |year= 2003 |pmid= 12801526 |doi=10.1016/S0145-2126(02)00325-9 }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{cite journal |vauthors=Ma BY, Mikolajczak SA, Danesh A, etal |title=The expression and the regulatory role of OX40 and 4-1BB heterodimer in activated human T cells |journal=Blood |volume=106 |issue= 6 |pages= 2002–10 |year= 2005 |pmid= 15941918 |doi= 10.1182/blood-2004-04-1622 }}
  • {{cite journal |vauthors=Takeshita F, Ishii KJ, Kobiyama K, etal |title=TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF |journal=Eur. J. Immunol. |volume=35 |issue= 8 |pages= 2477–85 |year= 2005 |pmid= 16052631 |doi= 10.1002/eji.200526151 }}
  • {{cite journal | vauthors=Abell AN, Johnson GL |title=MEKK4 is an effector of the embryonic TRAF4 for JNK activation |journal=J. Biol. Chem. |volume=280 |issue= 43 |pages= 35793–6 |year= 2006 |pmid= 16157600 |doi= 10.1074/jbc.C500260200 }}
{{refend}}{{Adaptor proteins}}{{Cytokine receptor modulators}}{{gene-17-stub}}
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