“TRA (gene)”的意思、由来-开放百科全书

T-cell receptor alpha locus is a protein that in humans is encoded by the TRA gene, also known as TCRA or TRA@.^[1]^[2]^[3] It contributes the alpha chain to the larger TCR protein (T-cell receptor).

References

1. ^{{cite journal |vauthors=Erikson J, Williams DL, Finan J, Nowell PC, Croce CM | title = Locus of the alpha-chain of the T-cell receptor is split by chromosome translocation in T-cell leukemias | journal = Science | volume = 229 | issue = 4715 | pages = 784–6 |date=Sep 1985 | pmid = 3875152 | pmc = | doi =10.1126/science.3875152 }}
2. ^{{cite journal |vauthors=Rabbitts TH, Lefranc MP, Stinson MA, Sims JE, Schroder J, Steinmetz M, Spurr NL, Solomon E, Goodfellow PN | title = The chromosomal location of T-cell receptor genes and a T cell rearranging gene: possible correlation with specific translocations in human T cell leukaemia | journal = EMBO J | volume = 4 | issue = 6 | pages = 1461–5 |date=Oct 1985 | pmid = 3875483 | pmc = 554368 | doi = }}
3. ^{{cite web | title = Entrez Gene: TRA@ T cell receptor alpha locus| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6955| accessdate = }}

Further reading

{{cite journal | author=Kenwrick S |title=Isolation and sequence of two genes associated with a CpG island 5' of the factor VIII gene |journal=Hum. Mol. Genet. |volume=1 |issue= 3 |pages= 179–86 |year= 1993 |pmid= 1303175 |doi=10.1093/hmg/1.3.179 |name-list-format=vanc| author2=Levinson B | author3=Taylor S | display-authors=3 | last4=Shapiro | first4=Amy | last5=Gitschier | first5=Jane }}

{{cite journal | author=Suzuki CK |title=Regulating the retention of T-cell receptor alpha chain variants within the endoplasmic reticulum: Ca(2+)-dependent association with BiP |journal=J. Cell Biol. |volume=114 |issue= 2 |pages= 189–205 |year= 1991 |pmid= 1649196 |doi=10.1083/jcb.114.2.189 | pmc=2289081 |name-list-format=vanc| author2=Bonifacino JS | author3=Lin AY | display-authors=3 | last4=Davis | first4=MM | last5=Klausner | first5=RD }}

{{cite journal |vauthors=Travis A, Amsterdam A, Belanger C, Grosschedl R |title=LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected] |journal=Genes Dev. |volume=5 |issue= 5 |pages= 880–94 |year= 1991 |pmid= 1827423 |doi=10.1101/gad.5.5.880 }}

{{cite journal |vauthors=Koning F, Maloy WL, Coligan JE |title=The implications of subunit interactions for the structure of the T cell receptor-CD3 complex |journal=Eur. J. Immunol. |volume=20 |issue= 2 |pages= 299–305 |year= 1990 |pmid= 2138083 |doi=10.1002/eji.1830200211 }}

{{cite journal | author=Dyer MJ |title=T-cell receptor delta/alpha rearrangements in lymphoid neoplasms |journal=Blood |volume=74 |issue= 3 |pages= 1073–83 |year= 1989 |pmid= 2546634 |doi= }}

{{cite journal |vauthors=Chilson OP, Kelly-Chilson AE |title=Mitogenic lectins bind to the antigen receptor on human lymphocytes |journal=Eur. J. Immunol. |volume=19 |issue= 2 |pages= 389–96 |year= 1989 |pmid= 2703017 |doi=10.1002/eji.1830190225 }}

{{cite journal | author=Yanagi Y |title=Analysis of cDNA clones specific for human T cells and the alpha and beta chains of the T-cell receptor heterodimer from a human T-cell line |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=82 |issue= 10 |pages= 3430–4 |year= 1985 |pmid= 3873654 |doi=10.1073/pnas.82.10.3430 | pmc=397789 |name-list-format=vanc| author2=Chan A | author3=Chin B | display-authors=3 | last4=Minden | first4=M | last5=Mak | first5=TW }}

{{cite journal | author=Sim GK |title=Primary structure of human T-cell receptor alpha-chain |journal=Nature |volume=312 |issue= 5996 |pages= 771–5 |year= 1985 |pmid= 6440030 |doi=10.1038/312771a0 |name-list-format=vanc| author2=Yagüe J | author3=Nelson J | display-authors=3 | last4=Marrack | first4=Philippa | last5=Palmer | first5=Edward | last6=Augustin | first6=Andrei | last7=Kappler | first7=John }}

{{cite journal |vauthors=Kearse KP, Roberts JL, Singer A |title=TCR alpha-CD3 delta epsilon association is the initial step in alpha beta dimer formation in murine T cells and is limiting in immature CD4+ CD8+ thymocytes |journal=Immunity |volume=2 |issue= 4 |pages= 391–9 |year= 1995 |pmid= 7719941 |doi= 10.1016/1074-7613(95)90147-7 }}

{{cite journal |vauthors=Manolios N, Kemp O, Li ZG |title=The T cell antigen receptor alpha and beta chains interact via distinct regions with CD3 chains |journal=Eur. J. Immunol. |volume=24 |issue= 1 |pages= 84–92 |year= 1994 |pmid= 8020575 |doi=10.1002/eji.1830240114 }}

{{cite journal |vauthors=Bagga R, Emerson BM |title=An HMG I/Y-containing repressor complex and supercoiled DNA topology are critical for long-range enhancer-dependent transcription in vitro |journal=Genes Dev. |volume=11 |issue= 5 |pages= 629–39 |year= 1997 |pmid= 9119227 |doi=10.1101/gad.11.5.629 }}

{{cite journal |vauthors=San José E, Sahuquillo AG, Bragado R, Alarcón B |title=Assembly of the TCR/CD3 complex: CD3 epsilon/delta and CD3 epsilon/gamma dimers associate indistinctly with both TCR alpha and TCR beta chains. Evidence for a double TCR heterodimer model |journal=Eur. J. Immunol. |volume=28 |issue= 1 |pages= 12–21 |year= 1998 |pmid= 9485181 |doi=10.1002/(SICI)1521-4141(199801)28:01<12::AID-IMMU12>3.0.CO;2-9 }}

{{cite journal | author=Ding YH |title=Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids |journal=Immunity |volume=8 |issue= 4 |pages= 403–11 |year= 1998 |pmid= 9586631 |doi=10.1016/S1074-7613(00)80546-4 |name-list-format=vanc| author2=Smith KJ | author3=Garboczi DN | display-authors=3 | last4=Utz | first4=Ursula | last5=Biddison | first5=William E. | last6=Wiley | first6=Don C. }}

{{cite journal | author=Kirchgessner H |title=The Transmembrane Adaptor Protein Trim Regulates T Cell Receptor (Tcr) Expression and Tcr-Mediated Signaling via an Association with the Tcr ζ Chain |journal=J. Exp. Med. |volume=193 |issue= 11 |pages= 1269–84 |year= 2001 |pmid= 11390434 |doi=10.1084/jem.193.11.1269 | pmc=2193385 |name-list-format=vanc| author2=Dietrich J | author3=Scherer J | display-authors=3 | last4=Isomaki | first4=P. | last5=Korinek | first5=V. | last6=Hilgert | first6=I. | last7=Bruyns | first7=E. | last8=Leo | first8=A. | last9=Cope | first9=A. P. }}

{{cite journal | author=Shelton JG |title=Importance of the T cell receptor alpha-chain transmembrane distal region for assembly with cognate subunits |journal=Mol. Immunol. |volume=38 |issue= 4 |pages= 259–65 |year= 2001 |pmid= 11566319 |doi=10.1016/S0161-5890(01)00062-1 |name-list-format=vanc| author2=Gülland S | author3=Nicolson K | display-authors=3 | last4=Kearse | first4=Kelly P | last5=Thomas Bäckström | first5=B }}

{{cite journal | author=Pietra G |title=The analysis of the natural killer-like activity of human cytolytic T lymphocytes revealed HLA-E as a novel target for TCR alpha/beta-mediated recognition |journal=Eur. J. Immunol. |volume=31 |issue= 12 |pages= 3687–93 |year= 2002 |pmid= 11745389 |doi=10.1002/1521-4141(200112)31:12<3687::AID-IMMU3687>3.0.CO;2-C |name-list-format=vanc| author2=Romagnani C | author3=Falco M | display-authors=3 | last4=Vitale | first4=Massimo | last5=Castriconi | first5=Roberta | last6=Pende | first6=Daniela | last7=Millo | first7=Enrico | last8=Anfossi | first8=Simone | last9=Biassoni | first9=Roberto }}

{{cite journal |vauthors=Hennecke J, Wiley DC |title=Structure of a Complex of the Human α/β T Cell Receptor (TCR) HA1.7, Influenza Hemagglutinin Peptide, and Major Histocompatibility Complex Class II Molecule, HLA-DR4 (DRA0101 and DRB10401): Insight into TCR Cross-Restriction and Alloreactivity |journal=J. Exp. Med. |volume=195 |issue= 5 |pages= 571–81 |year= 2002 |pmid= 11877480 |doi=10.1084/jem.20011194 | pmc=2193773 }}

{{cite journal | author=García P |title=Human T cell receptor-mediated recognition of HLA-E |journal=Eur. J. Immunol. |volume=32 |issue= 4 |pages= 936–44 |year= 2002 |pmid= 11920559 |doi=10.1002/1521-4141(200204)32:4<936::AID-IMMU936>3.0.CO;2-M |name-list-format=vanc| author2=Llano M | author3=de Heredia AB | display-authors=3 | last4=Willberg | first4=Christian B. | last5=Caparrós | first5=Esther | last6=Aparicio | first6=Pedro | last7=Braud | first7=Véronique M. | last8=López-Botet | first8=Miguel }}

1 : Proteins