“Transforming growth factor, beta 3”的意思、由来-开放百科全书

It is a type of protein, known as a cytokine, which is involved in cell differentiation, embryogenesis and development. It belongs to a large family of cytokines called the Transforming growth factor beta superfamily, which includes the TGF-β family, Bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs), inhibins and activins.^[3]

TGF-β3 is believed to regulate molecules involved in cellular adhesion and extracellular matrix (ECM) formation during the process of palate development. Without TGF-β3, mammals develop a deformity known as a cleft palate.^[4]^[5] This is caused by failure of epithelial cells in both sides of the developing palate to fuse. TGF-β3 also plays an essential role in controlling the development of lungs in mammals, by also regulating cell adhesion and ECM formation in this tissue,^[6] and controls wound healing by regulating the movements of epidermal and dermal cells in injured skin.^[1]

Interactions

Transforming growth factor, beta 3 has been shown to interact with TGF beta receptor 2.^[7]^[8]^[9]^[10]

Clinical research

After successful phase I/II trials,^[11] human recombinant TGF-β3 (Avotermin, planned trade name Juvista) failed in Phase III trials.^[12]

References

1. ^¹{{cite journal | vauthors = Bandyopadhyay B, Fan J, Guan S, Li Y, Chen M, Woodley DT, Li W | title = A "traffic control" role for TGFbeta3: orchestrating dermal and epidermal cell motility during wound healing | journal = The Journal of Cell Biology | volume = 172 | issue = 7 | pages = 1093–105 | date = Mar 2006 | pmid = 16549496 | pmc = 2063766 | doi = 10.1083/jcb.200507111 }}
2. ^{{cite web | title = Entrez Gene: TGFB3 transforming growth factor, beta 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7043| accessdate = }}
3. ^{{cite journal | vauthors = Herpin A, Lelong C, Favrel P | title = Transforming growth factor-beta-related proteins: an ancestral and widespread superfamily of cytokines in metazoans | journal = Developmental and Comparative Immunology | volume = 28 | issue = 5 | pages = 461–85 | date = May 2004 | pmid = 15062644 | doi = 10.1016/j.dci.2003.09.007 }}
4. ^{{cite journal | vauthors = Taya Y, O'Kane S, Ferguson MW | title = Pathogenesis of cleft palate in TGF-beta3 knockout mice | journal = Development | volume = 126 | issue = 17 | pages = 3869–79 | date = Sep 1999 | pmid = 10433915 }}
5. ^{{cite journal | vauthors = Dudas M, Nagy A, Laping NJ, Moustakas A, Kaartinen V | title = Tgf-beta3-induced palatal fusion is mediated by Alk-5/Smad pathway | journal = Developmental Biology | volume = 266 | issue = 1 | pages = 96–108 | date = Feb 2004 | pmid = 14729481 | doi = 10.1016/j.ydbio.2003.10.007 }}
6. ^{{cite journal | vauthors = Kaartinen V, Voncken JW, Shuler C, Warburton D, Bu D, Heisterkamp N, Groffen J | title = Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction | journal = Nature Genetics | volume = 11 | issue = 4 | pages = 415–21 | date = Dec 1995 | pmid = 7493022 | doi = 10.1038/ng1295-415 }}
7. ^{{cite journal | vauthors = De Crescenzo G, Pham PL, Durocher Y, O'Connor-McCourt MD | title = Transforming growth factor-beta (TGF-beta) binding to the extracellular domain of the type II TGF-beta receptor: receptor capture on a biosensor surface using a new coiled-coil capture system demonstrates that avidity contributes significantly to high affinity binding | journal = Journal of Molecular Biology | volume = 328 | issue = 5 | pages = 1173–83 | date = May 2003 | pmid = 12729750 | doi = 10.1016/S0022-2836(03)00360-7 }}
8. ^{{cite journal | vauthors = Hart PJ, Deep S, Taylor AB, Shu Z, Hinck CS, Hinck AP | title = Crystal structure of the human TbetaR2 ectodomain--TGF-beta3 complex | journal = Nature Structural Biology | volume = 9 | issue = 3 | pages = 203–8 | date = Mar 2002 | pmid = 11850637 | doi = 10.1038/nsb766 }}
9. ^{{cite journal | vauthors = Barbara NP, Wrana JL, Letarte M | title = Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily | journal = The Journal of Biological Chemistry | volume = 274 | issue = 2 | pages = 584–94 | date = Jan 1999 | pmid = 9872992 | doi = 10.1074/jbc.274.2.584 }}
10. ^{{cite journal | vauthors = Rotzer D, Roth M, Lutz M, Lindemann D, Sebald W, Knaus P | title = Type III TGF-beta receptor-independent signalling of TGF-beta2 via TbetaRII-B, an alternatively spliced TGF-beta type II receptor | journal = The EMBO Journal | volume = 20 | issue = 3 | pages = 480–90 | date = Feb 2001 | pmid = 11157754 | pmc = 133482 | doi = 10.1093/emboj/20.3.480 }}
11. ^{{cite journal | vauthors = Ferguson MW, Duncan J, Bond J, Bush J, Durani P, So K, Taylor L, Chantrey J, Mason T, James G, Laverty H, Occleston NL, Sattar A, Ludlow A, O'Kane S | title = Prophylactic administration of avotermin for improvement of skin scarring: three double-blind, placebo-controlled, phase I/II studies | journal = Lancet | volume = 373 | issue = 9671 | pages = 1264–74 | date = Apr 2009 | pmid = 19362676 | doi = 10.1016/S0140-6736(09)60322-6 | url = http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(09)60322-6/abstract}}
12. ^Renovo shares plummet 75% as scar revision product Juvista fails to meet study endpoints, 14 February 2011

Interactions

Clinical research

References

Further reading

External links