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词条 Translin
释义

  1. Function

  2. Interactions

  3. References

  4. Further reading

{{Use dmy dates|date=March 2014}}{{Infobox_gene}}Translin is a DNA-binding protein that in humans is encoded by the TSN gene.[1][2][3] Together with translin-associated factor X, translin forms the component 3 of promoter of RISC (C3PO) complex which facilitates endonucleolytic cleavage of the passenger strand during microRNA loading into the RNA-induced silencing complex (RISC).[4][5][6]

Function

This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms.[3]

Interactions

Translin has been shown to interact with PPP1R15A.[7]

References

1. ^{{cite journal | vauthors = Kasai M, Aoki K, Matsuo Y, Minowada J, Maziarz RT, Strominger JL | title = Recombination hotspot associated factors specifically recognize novel target sequences at the site of interchromosomal rearrangements in T-ALL patients with t(8;14)(q24;q11) and t(1;14)(p32;q11) | journal = International Immunology | volume = 6 | issue = 7 | pages = 1017–25 | date = Jul 1994 | pmid = 7947454 | pmc = | doi = 10.1093/intimm/6.7.1017 }}
2. ^{{cite journal | vauthors = Aoki K, Inazawa J, Takahashi T, Nakahara K, Kasai M | title = Genomic structure and chromosomal localization of the gene encoding translin, a recombination hotspot binding protein | journal = Genomics | volume = 43 | issue = 2 | pages = 237–41 | date = Jul 1997 | pmid = 9244443 | pmc = | doi = 10.1006/geno.1997.4796 }}
3. ^1 {{cite web | title = Entrez Gene: TSN translin| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7247| accessdate = }}
4. ^{{cite journal | vauthors = Liu Y, Ye X, Jiang F, Liang C, Chen D, Peng J, Kinch LN, Grishin NV, Liu Q | title = C3PO, an endoribonuclease that promotes RNAi by facilitating RISC activation | journal = Science | volume = 325 | issue = 5941 | pages = 750–3 | date = Aug 2009 | pmid = 19661431 | doi = 10.1126/science.1176325 | pmc=2855623}}
5. ^{{cite journal | vauthors = Ye X, Huang N, Liu Y, Paroo Z, Huerta C, Li P, Chen S, Liu Q, Zhang H | title = Structure of C3PO and mechanism of human RISC activation | journal = Nature Structural & Molecular Biology | volume = 18 | issue = 6 | pages = 650–7 | date = Jun 2011 | pmid = 21552258 | doi = 10.1038/nsmb.2032 | pmc=3109212}}
6. ^{{cite journal | vauthors = Ha M, Kim VN | title = Regulation of microRNA biogenesis | journal = Nature Reviews Molecular Cell Biology | volume = 15 | issue = 8 | pages = 509–24 | date = Aug 2014 | pmid = 25027649 | doi = 10.1038/nrm3838 }}
7. ^{{cite journal | vauthors = Hasegawa T, Isobe K | title = Evidence for the interaction between Translin and GADD34 in mammalian cells | journal = Biochimica et Biophysica Acta | volume = 1428 | issue = 2–3 | pages = 161–8 | date = Aug 1999 | pmid = 10434033 | doi = 10.1016/s0304-4165(99)00060-4 }}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Aoki K, Suzuki K, Sugano T, Tasaka T, Nakahara K, Kuge O, Omori A, Kasai M | title = A novel gene, Translin, encodes a recombination hotspot binding protein associated with chromosomal translocations | journal = Nature Genetics | volume = 10 | issue = 2 | pages = 167–74 | date = Jun 1995 | pmid = 7663511 | doi = 10.1038/ng0695-167 }}
  • {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | date = Jan 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
  • {{cite journal | vauthors = Aoki K, Nakahara K, Ikegawa C, Seto M, Takahashi T, Minowada J, Strominger JL, Maziarz RT, Kasai M | title = Nuclear proteins binding to a novel target sequence within the recombination hotspot regions of Bcl-2 and the immunoglobulin DH gene family | journal = Oncogene | volume = 9 | issue = 4 | pages = 1109–15 | date = Apr 1994 | pmid = 8134113 | doi = }}
  • {{cite journal | vauthors = Aoki K, Ishida R, Kasai M | title = Isolation and characterization of a cDNA encoding a Translin-like protein, TRAX | journal = FEBS Letters | volume = 401 | issue = 2–3 | pages = 109–12 | date = Jan 1997 | pmid = 9013868 | doi = 10.1016/S0014-5793(96)01444-5 }}
  • {{cite journal | vauthors = Kasai M, Matsuzaki T, Katayanagi K, Omori A, Maziarz RT, Strominger JL, Aoki K, Suzuki K | title = The translin ring specifically recognizes DNA ends at recombination hot spots in the human genome | journal = The Journal of Biological Chemistry | volume = 272 | issue = 17 | pages = 11402–7 | date = Apr 1997 | pmid = 9111049 | doi = 10.1074/jbc.272.17.11402 }}
  • {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | date = Oct 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
  • {{cite journal | vauthors = Hasegawa T, Isobe K | title = Evidence for the interaction between Translin and GADD34 in mammalian cells | journal = Biochimica et Biophysica Acta | volume = 1428 | issue = 2–3 | pages = 161–8 | date = Aug 1999 | pmid = 10434033 | doi = 10.1016/s0304-4165(99)00060-4 }}
  • {{cite journal | vauthors = Badge RM, Yardley J, Jeffreys AJ, Armour JA | title = Crossover breakpoint mapping identifies a subtelomeric hotspot for male meiotic recombination | journal = Human Molecular Genetics | volume = 9 | issue = 8 | pages = 1239–44 | date = May 2000 | pmid = 10767349 | doi = 10.1093/hmg/9.8.1239 }}
  • {{cite journal | vauthors = Hosaka T, Kanoe H, Nakayama T, Murakami H, Yamamoto H, Nakamata T, Tsuboyama T, Oka M, Kasai M, Sasaki MS, Nakamura T, Toguchida J | title = Translin binds to the sequences adjacent to the breakpoints of the TLS and CHOP genes in liposarcomas with translocation t(12;6) | journal = Oncogene | volume = 19 | issue = 50 | pages = 5821–5 | date = Nov 2000 | pmid = 11126370 | doi = 10.1038/sj.onc.1203943 }}
  • {{cite journal | vauthors = Chennathukuzhi VM, Kurihara Y, Bray JD, Hecht NB | title = Trax (translin-associated factor X), a primarily cytoplasmic protein, inhibits the binding of TB-RBP (translin) to RNA | journal = The Journal of Biological Chemistry | volume = 276 | issue = 16 | pages = 13256–63 | date = Apr 2001 | pmid = 11278549 | doi = 10.1074/jbc.M009707200 }}
  • {{cite journal | vauthors = Lee SP, Fuior E, Lewis MS, Han MK | title = Analytical ultracentrifugation studies of translin: analysis of protein-DNA interactions using a single-stranded fluorogenic oligonucleotide | journal = Biochemistry | volume = 40 | issue = 46 | pages = 14081–8 | date = Nov 2001 | pmid = 11705401 | doi = 10.1021/bi010302t }}
  • {{cite journal | vauthors = Erdemir T, Bilican B, Oncel D, Goding CR, Yavuzer U | title = DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX) | journal = Journal of Cell Science | volume = 115 | issue = Pt 1 | pages = 207–16 | date = Jan 2002 | pmid = 11801738 | doi = }}
  • {{cite journal | vauthors = Han MK, Lin P, Paek D, Harvey JJ, Fuior E, Knutson JR | title = Fluorescence studies of pyrene maleimide-labeled translin: excimer fluorescence indicates subunits associate in a tail-to-tail configuration to form octamer | journal = Biochemistry | volume = 41 | issue = 10 | pages = 3468–76 | date = Mar 2002 | pmid = 11876655 | doi = 10.1021/bi015901e }}
  • {{cite journal | vauthors = Sengupta K, Rao BJ | title = Translin binding to DNA: recruitment through DNA ends and consequent conformational transitions | journal = Biochemistry | volume = 41 | issue = 51 | pages = 15315–26 | date = Dec 2002 | pmid = 12484770 | doi = 10.1021/bi026378m }}
  • {{cite journal | vauthors = Li K, Wang L, Cheng J, Lu YY, Zhang LX, Mu JS, Hong Y, Liu Y, Duan HJ, Wang G, Li L, Chen JM | title = Interaction between hepatitis C virus core protein and translin protein--a possible molecular mechanism for hepatocellular carcinoma and lymphoma caused by hepatitis C virus | journal = World Journal of Gastroenterology | volume = 9 | issue = 2 | pages = 300–3 | date = Feb 2003 | pmid = 12532453 | doi = 10.3748/wjg.v9.i2.300 }}
  • {{cite journal | vauthors = Yang S, Cho YS, Chennathukuzhi VM, Underkoffler LA, Loomes K, Hecht NB | title = Translin-associated factor X is post-transcriptionally regulated by its partner protein TB-RBP, and both are essential for normal cell proliferation | journal = The Journal of Biological Chemistry | volume = 279 | issue = 13 | pages = 12605–14 | date = Mar 2004 | pmid = 14711818 | doi = 10.1074/jbc.M313133200 }}
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