Tread softly or tread-softly may refer to:

• Cnidoscolus aconitifolius, a woody plant of the spurge family (Euphorbiaceae)
• Cnidoscolus stimulosus (Spurge Nettle), an herbaceous plant of the spurge family (Euphorbiaceae)
• Solanum carolinense (Carolina Horsenettle), a plant of the nightshade family (Solanaceae)
• Tread Softly in This Place, a novel by Brian Cleeve
• "Tread softly because you tread on my dreams", a line from Yeats' poem "Aedh Wishes for the Cloths of Heaven"
• Tread Softly (1952 film), a 1952 British film
• Tread Softly (1965 film), a 1965 German film also known as Schüsse aus dem Geigengasten

• "Speak softly and carry a big stick", sometimes misquoted as "Tread..."

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