1. Function

2. Protein sequence

3. Homology

4. Gene neighborhood

5. References

6. Further reading

Function

The exact function of KIAA0644 is not known. It is, however, a member of the leucine-rich repeat family of proteins, which are known to be involved in protein-protein interactions. This protein is known to interact with the TLR4 protein.

TRIL is a component of the TLR4 complex and is induced in a number of cell types by lipopolysaccharide (LPS).^[2]

Protein sequence

The main isoform of the human protein is 811 amino long and is composed primarily of leucine (17%), alanine and arginine (~10%), and glycine (~ 8.5%) residues. The protein sequence is predicted to consists mostly of α-helices and a few β-sheet

Homology

KIAA0644 is conserved well among mammals but can be found in all chordates with lower sequence identities.

Gene neighborhood

The KIAA0644 gene is neighbors to mRNA-cAMP responsive element binding gene downstream and mRNA carboxypeptidase and serine carboxypeptidase gene upstream ^[3][4]

References

Further reading

• {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |pmc=139241 |doi= 10.1073/pnas.242603899 }}
• {{cite journal |vauthors=Scherer SW, Cheung J, MacDonald JR, etal |title=Human Chromosome 7: DNA Sequence and Biology |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |pmc=2882961 |doi= 10.1126/science.1083423 }}
• {{cite journal |vauthors=Büssow K, Cahill D, Nietfeld W, etal |title=A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library |journal=Nucleic Acids Res. |volume=26 |issue= 21 |pages= 5007–8 |year= 1998 |pmid= 9776767 |pmc=147919 |doi= 10.1093/nar/26.21.5007}}
• {{cite journal |vauthors=Wheeler HE, Metter EJ, Tanaka T, etal |title=Sequential Use of Transcriptional Profiling, Expression Quantitative Trait Mapping, and Gene Association Implicates MMP20 in Human Kidney Aging |journal=PLoS Genet. |volume=5 |issue= 10 |pages= e1000685 |year= 2009 |pmid= 19834535 |pmc=2752811 |doi= 10.1371/journal.pgen.1000685 |editor1-last=Gibson |editor1-first=Greg }}

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