1. Structure

2. Interactions

3. Role in cancer

4. References

5. Further reading

6. External links

The protein encoded by this gene is thought to be a transcriptional corepressor. However unlike the related TIF1-α and TIF1-β proteins, few transcription factors such as Smad4 that interact with TIF1-γ have been identified.^[1]

Structure

The protein is a member of the tripartite motif family.^[3] This motif includes three zinc-binding domains:

• RING
• B-box type 1 zinc finger
• B-box type 2 zinc finger

and a coiled-coil region.

Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined.^[1]

Interactions

TRIM33 has been shown to interact with TRIM24.^[4]

Role in cancer

TRIM33 acts as a tumor suppressor gene preventing the development chronic myelomonocytic leukemia.^[5]

TRIM33 regulates also the TGF-β1 receptor and promotes physiological aging of hematopoietic stem cells.

TRIM33 acts as an oncogene by preventing apoptosis in B-cell leukemias.^[7]

References

Further reading

• {{cite journal | vauthors = Venturini L, You J, Stadler M, Galien R, Lallemand V, Koken MH, Mattei MG, Ganser A, Chambon P, Losson R, de Thé H | title = TIF1gamma, a novel member of the transcriptional intermediary factor 1 family | journal = Oncogene | volume = 18 | issue = 5 | pages = 1209–17 | date = February 1999 | pmid = 10022127 | doi = 10.1038/sj.onc.1202655 }}
• {{cite journal | vauthors = Klugbauer S, Rabes HM | title = The transcription coactivator HTIF1 and a related protein are fused to the RET receptor tyrosine kinase in childhood papillary thyroid carcinomas | journal = Oncogene | volume = 18 | issue = 30 | pages = 4388–93 | date = July 1999 | pmid = 10439047 | doi = 10.1038/sj.onc.1202824 }}
• {{cite journal | vauthors = Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 6 | issue = 3 | pages = 197–205 | date = June 1999 | pmid = 10470851 | doi = 10.1093/dnares/6.3.197 }}
• {{cite journal | vauthors = Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A | title = The tripartite motif family identifies cell compartments | journal = The EMBO Journal | volume = 20 | issue = 9 | pages = 2140–51 | date = May 2001 | pmid = 11331580 | pmc = 125245 | doi = 10.1093/emboj/20.9.2140 }}
• {{cite journal | vauthors = Peng H, Feldman I, Rauscher FJ | title = Hetero-oligomerization among the TIF family of RBCC/TRIM domain-containing nuclear cofactors: a potential mechanism for regulating the switch between coactivation and corepression | journal = Journal of Molecular Biology | volume = 320 | issue = 3 | pages = 629–44 | date = July 2002 | pmid = 12096914 | doi = 10.1016/S0022-2836(02)00477-1 }}
• {{cite journal | vauthors = Yoon HG, Chan DW, Reynolds AB, Qin J, Wong J | title = N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso | journal = Molecular Cell | volume = 12 | issue = 3 | pages = 723–34 | date = September 2003 | pmid = 14527417 | doi = 10.1016/j.molcel.2003.08.008 }}
• {{cite journal | vauthors = Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW | title = Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation | journal = Nature Biotechnology | volume = 22 | issue = 6 | pages = 707–16 | date = June 2004 | pmid = 15146197 | doi = 10.1038/nbt971 }}
• {{cite journal | vauthors = Dupont S, Zacchigna L, Cordenonsi M, Soligo S, Adorno M, Rugge M, Piccolo S | title = Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase | journal = Cell | volume = 121 | issue = 1 | pages = 87–99 | date = April 2005 | pmid = 15820681 | doi = 10.1016/j.cell.2005.01.033 }}
• {{cite journal | vauthors = He W, Dorn DC, Erdjument-Bromage H, Tempst P, Moore MA, Massagué J | title = Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway | journal = Cell | volume = 125 | issue = 5 | pages = 929–41 | date = June 2006 | pmid = 16751102 | doi = 10.1016/j.cell.2006.03.045 }}

External links

• {{MeshName|TRIM33+protein,+human}}

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