| 词条 | Trimazosin |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 448137147 | IUPAC_name = (2-Hydroxy-2-methylpropyl) 4-(4-amino-6,7,8-trimethoxyquinazolin-2-yl)piperazine-1-carboxylate | image = Trimazosin.svg | width = 275 | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 53746-46-6 | ATC_prefix = C02 | ATC_suffix = CA03 | PubChem = 37264 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 31L760807H | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 513301 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 34203 | KEGG_Ref = {{keggcite|changed|kegg}} | KEGG = D08212 | smiles = O=C(OCC(O)(C)C)N3CCN(c1nc(N)c2c(n1)c(OC)c(OC)c(OC)c2)CC3 | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C20H29N5O6/c1-20(2,27)11-31-19(26)25-8-6-24(7-9-25)18-22-14-12(17(21)23-18)10-13(28-3)15(29-4)16(14)30-5/h10,27H,6-9,11H2,1-5H3,(H2,21,22,23) | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = YNZXWQJZEDLQEG-UHFFFAOYSA-N | C=20 | H=29 | N=5 | O=6 | molecular_weight = 435.47 g/mol }}Trimazosin is a sympatholytic alpha blocker.[1][2] References1. ^{{cite journal |vauthors=van Kalken CK, van der Meulen J, Oe PL, Vriesendorp R, Donker AJ |title=Pharmacokinetics of trimazosin and its effects on blood pressure, renal function and proteinuria during short-term therapy of patients with impaired renal function and hypertension |journal=Eur. J. Clin. Pharmacol. |volume=31 |issue=1 |pages=63–8 |year=1986 |pmid=3780829 |doi= 10.1007/BF00870988|url=}} {{Adrenergics}}{{Antihypertensives and diuretics}}{{Piperazines}}{{antihypertensive-stub}}2. ^{{US Patent|3,669,968}} 4 : Carbamates|Phenol ethers|Piperazines|Quinazolines |
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