| 释义 |
- Function
- See also
- References
- Further reading
{{Infobox_gene}}Thyroid stimulating hormone, beta also known as TSHB is a protein which in humans is encoded by the TSHB gene.[1][2] Function Thyrotropin-stimulating hormone (TSH) is a noncovalently linked glycoprotein heterodimer and is part of a family of pituitary hormones containing a common alpha subunit (TSHA) and a unique beta subunit (this protein) that confers specificity.[3] See also- thyroid stimulating hormone
References 1. ^{{cite journal |vauthors=Wondisford FE, Radovick S, Moates JM, Usala SJ, Weintraub BD | title = Isolation and characterization of the human thyrotropin beta-subunit gene. Differences in gene structure and promoter function from murine species | journal = J. Biol. Chem. | volume = 263 | issue = 25 | pages = 12538–42 |date=September 1988 | pmid = 2457586 | doi = | url = http://www.jbc.org/cgi/pmidlookup?view=long&pmid=2457586 }}
2. ^{{cite journal |vauthors=Tatsumi K, Hayashizaki Y, Hiraoka Y, Miyai K, Matsubara K | title = The structure of the human thyrotropin beta-subunit gene | journal = Gene | volume = 73 | issue = 2 | pages = 489–97 |date=December 1988 | pmid = 3243440 | doi = 10.1016/0378-1119(88)90513-6| url = }}
3. ^{{cite web | title = Entrez Gene: TSHB | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7252 | accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Bonomi M, Proverbio MC, Weber G, etal |title=Hyperplastic pituitary gland, high serum glycoprotein hormone alpha-subunit, and variable circulating thyrotropin (TSH) levels as hallmark of central hypothyroidism due to mutations of the TSH beta gene. |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 4 |pages= 1600–4 |year= 2001 |pmid= 11297590 |doi=10.1210/jc.86.4.1600 }}
- {{cite journal |vauthors=Vuissoz JM, Deladoëy J, Buyukgebiz A |title=New autosomal recessive mutation of the TSH-beta subunit gene causing central isolated hypothyroidism. |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 9 |pages= 4468–71 |year= 2001 |pmid= 11549695 |doi=10.1210/jc.86.9.4468 |display-authors=etal}}
- {{cite journal |vauthors=Karges B, LeHeup B, Schoenle E, etal |title=Compound heterozygous and homozygous mutations of the TSHbeta gene as a cause of congenital central hypothyroidism in Europe. |journal=Horm. Res. |volume=62 |issue= 3 |pages= 149–55 |year= 2004 |pmid= 15297803 |doi= 10.1159/000080071 }}
- {{cite journal |vauthors=Kabadi UM, Premachandra BN |title=Serum thyrotropin in Graves' disease: a more reliable index of circulating thyroid-stimulating immunoglobulin level than thyroid function? |journal=Endocr Pract |volume=13 |issue= 6 |pages= 615–9 |year= 2007 |pmid= 17954417 |doi= 10.4158/ep.13.6.615}}
- {{cite journal |vauthors=Miyai S, Yoshimura S, Iwasaki Y, etal |title=Induction of GH, PRL, and TSH beta mRNA by transfection of Pit-1 in a human pituitary adenoma-derived cell line. |journal=Cell Tissue Res. |volume=322 |issue= 2 |pages= 269–77 |year= 2005 |pmid= 16133148 |doi= 10.1007/s00441-005-0033-z }}
- {{cite journal |author=Pierce JG |title=Eli Lilly lecture. The subunits of pituitary thyrotropin--their relationship to other glycoprotein hormones. |journal=Endocrinology |volume=89 |issue= 6 |pages= 1331–44 |year= 1971 |pmid= 5002675 |doi=10.1210/endo-89-6-1331 }}
- {{cite journal |vauthors=Atzmon G, Barzilai N, Surks MI, Gabriely I |title=Genetic Predisposition to Elevated Serum Thyrotropin Is Associated with Exceptional Longevity |journal=J. Clin. Endocrinol. Metab. |volume=94 |issue= 12 |pages= 4768–75 |year= 2009 |pmid= 19837933 |doi= 10.1210/jc.2009-0808 |pmc=2795660 }}
- {{cite journal |vauthors=Landa I, Ruiz-Llorente S, Montero-Conde C, etal |title=The Variant rs1867277 in FOXE1 Gene Confers Thyroid Cancer Susceptibility through the Recruitment of USF1/USF2 Transcription Factors |journal=PLoS Genet. |volume=5 |issue= 9 |pages= e1000637 |year= 2009 |pmid= 19730683 |doi= 10.1371/journal.pgen.1000637 |pmc=2727793 |editor1-last=Gibson |editor1-first=Greg }}
- {{cite journal |vauthors=Pohlenz J, Dumitrescu A, Aumann U, etal |title=Congenital secondary hypothyroidism caused by exon skipping due to a homozygous donor splice site mutation in the TSHbeta-subunit gene |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 1 |pages= 336–9 |year= 2002 |pmid= 11788671 |doi=10.1210/jc.87.1.336 }}
- {{cite journal |vauthors=Miyoshi I, Kasai N, Hayashizaki Y |title=[Structure and regulation of human thyroid-stimulating hormone (TSH) gene] |journal=Nippon Rinsho |volume=52 |issue= 4 |pages= 940–7 |year= 1994 |pmid= 8196184 |doi= }}
- {{cite journal |vauthors=Borck G, Topaloglu AK, Korsch E, etal |title=Four new cases of congenital secondary hypothyroidism due to a splice site mutation in the thyrotropin-beta gene: phenotypic variability and founder effect |journal=J. Clin. Endocrinol. Metab. |volume=89 |issue= 8 |pages= 4136–41 |year= 2004 |pmid= 15292359 |doi= 10.1210/jc.2004-0494 }}
- {{cite journal |vauthors=Comings DE, Gade-Andavolu R, Gonzalez N, etal |title=A multivariate analysis of 59 candidate genes in personality traits: the temperament and character inventory |journal=Clin. Genet. |volume=58 |issue= 5 |pages= 375–85 |year= 2000 |pmid= 11140838 |doi=10.1034/j.1399-0004.2000.580508.x }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 |pmc=528928 }}
- {{cite journal |vauthors=Clark AG, Glanowski S, Nielsen R, etal |title=Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios |journal=Science |volume=302 |issue= 5652 |pages= 1960–3 |year= 2003 |pmid= 14671302 |doi= 10.1126/science.1088821 }}
- {{cite journal |vauthors=Loinder K, Söderström M |title=An LXXLL motif in nuclear receptor corepressor mediates ligand-induced repression of the thyroid stimulating hormone-beta gene |journal=J. Steroid Biochem. Mol. Biol. |volume=97 |issue= 4 |pages= 322–7 |year= 2005 |pmid= 16216492 |doi= 10.1016/j.jsbmb.2005.06.031 }}
- {{cite journal |author=Luttrell LM |title=Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors |journal=Mol. Biotechnol. |volume=39 |issue= 3 |pages= 239–64 |year= 2008 |pmid= 18240029 |doi= 10.1007/s12033-008-9031-1 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241 }}
- {{cite journal |vauthors=Brumm H, Pfeufer A, Biebermann H, etal |title=Congenital central hypothyroidism due to homozygous thyrotropin beta 313 Delta T mutation is caused by a Founder effect |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 10 |pages= 4811–6 |year= 2002 |pmid= 12364478 |doi=10.1210/jc.2002-020297 }}
- {{cite journal |vauthors=Benhadi N, Wiersinga WM, Reitsma JB, etal |title=Higher maternal TSH levels in pregnancy are associated with increased risk for miscarriage, fetal or neonatal death |journal=Eur. J. Endocrinol. |volume=160 |issue= 6 |pages= 985–91 |year= 2009 |pmid= 19273570 |doi= 10.1530/EJE-08-0953 }}
- {{cite journal |vauthors=Schaefer JS, Klein JR |title=A novel thyroid stimulating hormone β-subunit isoform in human pituitary, peripheral blood leukocytes, and thyroid |journal=Gen. Comp. Endocrinol. |volume=162 |issue= 3 |pages= 241–4 |year= 2009 |pmid= 19364510 |doi= 10.1016/j.ygcen.2009.04.006 |pmc=2689139 }}
{{refend}}{{NLM content}}{{Hormones}}{{Protein and peptide receptor modulators}}{{gene-1-stub}} |