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词条 TWF1
释义

  1. Model organisms

  2. References

  3. Further reading

{{Infobox_gene}}Twinfilin-1 is a protein that in humans is encoded by the TWF1 gene.[1][2]{{PBB_Summary
| section_title =
| summary_text = This gene encodes twinfilin, an actin monomer-binding protein conserved from yeast to mammals. Studies of the mouse counterpart suggest that this protein may be an actin monomer-binding protein, and its localization to cortical G-actin-rich structures may be regulated by the small GTPase RAC1.[2]
}}

Model organisms

Model organisms have been used in the study of TWF1 function. A conditional knockout mouse line, called Twf1tm1a(EUCOMM)Wtsi[9][10] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[11][12][13]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[7][14] Twenty three tests were carried out on mutant mice, but no significant abnormalities were observed.[7]

References

1. ^{{cite journal | vauthors = Beeler JF, LaRochelle WJ, Chedid M, Tronick SR, Aaronson SA | title = Prokaryotic expression cloning of a novel human tyrosine kinase | journal = Mol. Cell. Biol. | volume = 14 | issue = 2 | pages = 982–8 | date = February 1994 | pmid = 7507208 | pmc = 358453 }}
2. ^1 {{cite web | title = Entrez Gene: TWF1 twinfilin, actin-binding protein, homolog 1 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5756| accessdate = }}
3. ^{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MBSL/eye-morphology/ |title=Eye morphology data for Twf1 |publisher=Wellcome Trust Sanger Institute}}
4. ^{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MBSL/plasma-chemistry/ |title=Clinical chemistry data for Twf1 |publisher=Wellcome Trust Sanger Institute}}
5. ^{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MBSL/salmonella-challenge/ |title=Salmonella infection data for Twf1 |publisher=Wellcome Trust Sanger Institute}}
6. ^{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MBSL/citrobacter-challenge/ |title=Citrobacter infection data for Twf1 |publisher=Wellcome Trust Sanger Institute}}
7. ^1 2 {{cite journal| doi = 10.1111/j.1755-3768.2010.4142.x| title = The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice| year = 2010| author = Gerdin AK| journal = Acta Ophthalmologica| volume = 88| issue = S248 }}
8. ^Mouse Resources Portal, Wellcome Trust Sanger Institute.
9. ^{{cite web |url=http://www.knockoutmouse.org/martsearch/search?query=Twf1 |title=International Knockout Mouse Consortium}}
10. ^{{cite web |url=http://www.informatics.jax.org/searchtool/Search.do?query=MGI:4434218 |title=Mouse Genome Informatics}}
11. ^{{Cite journal| last1 = Skarnes |first1 =W. C.| doi = 10.1038/nature10163 | last2 = Rosen | first2 = B.| last3 = West | first3 = A. P.| last4 = Koutsourakis | first4 = M.| last5 = Bushell | first5 = W.| last6 = Iyer | first6 = V.| last7 = Mujica | first7 = A. O.| last8 = Thomas | first8 = M.| last9 = Harrow | first9 = J.| last10 = Cox | first10 = T.| last11 = Jackson | first11 = D.| last12 = Severin | first12 = J.| last13 = Biggs | first13 = P.| last14 = Fu | first14 = J.| last15 = Nefedov | first15 = M.| last16 = De Jong | first16 = P. J.| last17 = Stewart | first17 = A. F.| last18 = Bradley | first18 = A. | title = A conditional knockout resource for the genome-wide study of mouse gene function | journal = Nature | volume = 474 | issue = 7351 | pages = 337–342 | year = 2011 | pmid = 21677750 | pmc =3572410 }}
12. ^{{cite journal |author=Dolgin E |title=Mouse library set to be knockout |journal=Nature |volume=474 |issue=7351 |pages=262–3 |date=June 2011 |pmid=21677718 |doi=10.1038/474262a }}
13. ^{{cite journal |vauthors=Collins FS, Rossant J, Wurst W |title=A mouse for all reasons |journal=Cell |volume=128 |issue=1 |pages=9–13 |date=January 2007 |pmid=17218247 |doi=10.1016/j.cell.2006.12.018 }}
14. ^{{cite journal|vauthors=van der Weyden L, White JK, Adams DJ, Logan DW | title=The mouse genetics toolkit: revealing function and mechanism. | journal=Genome Biol | year= 2011 | volume= 12 | issue= 6 | pages= 224 | pmid=21722353 | doi=10.1186/gb-2011-12-6-224 | pmc=3218837}}

Further reading

{{refbegin | 2}}
  • {{cite journal |vauthors=Palmgren S, Vartiainen M, Lappalainen P |title=Twinfilin, a molecular mailman for actin monomers. |journal=J. Cell Sci. |volume=115 |issue= Pt 5 |pages= 881–6 |year= 2002 |pmid= 11870207 |doi= }}
  • {{cite journal |vauthors=Hassel S, Eichner A, Yakymovych M, etal |title=Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry. |journal=Proteomics |volume=4 |issue= 5 |pages= 1346–58 |year= 2004 |pmid= 15188402 |doi= 10.1002/pmic.200300770 }}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
  • {{cite journal |vauthors=Vartiainen MK, Sarkkinen EM, Matilainen T, etal |title=Mammals have two twinfilin isoforms whose subcellular localizations and tissue distributions are differentially regulated. |journal=J. Biol. Chem. |volume=278 |issue= 36 |pages= 34347–55 |year= 2003 |pmid= 12807912 |doi= 10.1074/jbc.M303642200 }}
  • {{cite journal |vauthors=Galey D, Becker K, Haughey N, etal |title=Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes. |journal=J. Neurovirol. |volume=9 |issue= 3 |pages= 358–71 |year= 2003 |pmid= 12775419 |doi=10.1080/13550280390201119 }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
  • {{cite journal |vauthors=Ojala PJ, Paavilainen VO, Vartiainen MK, etal |title=The two ADF-H domains of twinfilin play functionally distinct roles in interactions with actin monomers. |journal=Mol. Biol. Cell |volume=13 |issue= 11 |pages= 3811–21 |year= 2003 |pmid= 12429826 |doi= 10.1091/mbc.E02-03-0157 | pmc=133594 }}
  • {{cite journal |vauthors=Paavilainen VO, Merckel MC, Falck S, etal |title=Structural conservation between the actin monomer-binding sites of twinfilin and actin-depolymerizing factor (ADF)/cofilin. |journal=J. Biol. Chem. |volume=277 |issue= 45 |pages= 43089–95 |year= 2003 |pmid= 12207032 |doi= 10.1074/jbc.M208225200 }}
{{refend}}{{PDB Gallery|geneid=5756}}{{gene-12-stub}}

1 : Genes mutated in mice
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