“U937 (cell line)”的意思、由来-开放百科全书

U937 cells are a model cell line used in biomedical research.^[1] They were isolated from the histiocytic lymphoma of a 37-year-old male patient ^[2] and are used to study the behaviour and differentiation of monocytes. U937 cells mature and differentiate in response to a number of soluble stimuli, adopting the morphology and characteristics of mature macrophages.

U937 cells are of the myeloid lineage and so secrete a large number of cytokines and chemokines either constitutively (e.g. IL-1 and GM-CSF) or in response to soluble stimuli. TNFα and recombinant GM-CSF independently promote IL-10 production in U937 cells.^[3]

The HLA alleles present in U937 cells are HLA-A*03:01, A*31:01, B*18:01, B*51:01, Cw*01:02 and Cw*07:02.^[4]

References

1. ^{{cite web | title = U937 - Cytokines and Cells Online Pathfinder Encyclopaedia| url = http://www.copewithcytokines.de/cope.cgi?key=U937| accessdate = }}
2. ^{{cite journal | author = Sundström C | title = Establishment and characterization of a human histiocytic lymphoma cell line (U-937) | journal = Int. J. Cancer | volume = 17 | issue = 5 | pages = 565–77 | date = May 1976 | pmid = 178611 | doi=10.1002/ijc.2910170504}}
3. ^{{cite journal | doi = 10.1016/S0161-5890(98)00043-1 | author = Lehmann MH| title = Recombinant human granulocyte-macrophage colony-stimulating factor triggers interleukin-10 expression in the monocytic cell line U937 | journal = Mol. Immunol. | volume = 35 | issue = 8 | pages = 479–485 |date=June 1998 | pmid = 9798652 | pmc = | url = | issn = }}
4. ^{{cite journal | doi = 10.1016/j.humimm.2006.08.294 | author = Gebreselassie D| title = Sampling of major histocompatibility complex class I-associated peptidome suggests relatively looser global association of HLA-B*5101 with peptides. | journal = Hum. Immunol. | volume = 67 | issue = 11 | pages = 894–906 |date=November 2006 | pmid = 17145369| pmc = 2269730 | url = | issn = }}

References

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