| 词条 | UB-165 |
| 释义 |
| verifiedrevid = 451224064 | IUPAC_name = (1R,6R)-5-(6-chloropyridin-3-yl)-9-azabicyclo[4.2.1]non-4-ene | image = UB-165_structure.png | width = 240 | tradename = | routes_of_administration = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 200432-86-6 | ATC_suffix = | PubChem = 5310970 | C=13 | H=15 | Cl=1 | N=2 | molecular_weight = 234.724 | smiles = c2nc(Cl)ccc2C1=CCCC3CCC1N3 }}UB-165 is a drug which acts as an agonist at neuronal nicotinic acetylcholine receptors being a full agonist of the α3β2 isoform and a partial agonist of the α4β2* isoform. It is used to study the role of this receptor subtype in the release of dopamine and noradrenaline in the brain,[1][2] and has also been used as a lead compound to derive a number of other selective nicotinic receptor ligands.[3][4][5][6] References1. ^{{Cite journal| pmid = 10751429| year = 2000| last1 = Sharples | first1 = C. G.| last2 = Kaiser| last3 = Soliakov | first3 = L.| last4 = Marks | first4 = M. J.| last5 = Collins | first5 = A. C.| last6 = Washburn | first6 = M.| last7 = Wright | first7 = E.| last8 = Spencer | first8 = J. A.| last9 = Gallagher | first9 = T.| last10 = Whiteaker | first10 = P.| last11 = Wonnacott | first11 = S.| title = UB-165: a novel nicotinic agonist with subtype selectivity implicates the alpha4beta2* subtype in the modulation of dopamine release from rat striatal synaptosomes| volume = 20| issue = 8| pages = 2783–2791| journal = Journal of Neuroscience | first2 = P.}} {{Stimulants}}{{Nootropics}}{{Nicotinic acetylcholine receptor modulators}}2. ^{{Cite journal| last1 = Cao | first1 = Y.| last2 = Surowy | first2 = C.| last3 = Puttfarcken | first3 = P.| title = Nicotinic acetylcholine receptor-mediated 3Hdopamine release from hippocampus| journal = The Journal of Pharmacology and Experimental Therapeutics| volume = 312| issue = 3| pages = 1298–1304| year = 2005| pmid = 15542623| doi = 10.1124/jpet.104.076794}} 3. ^{{Cite journal| pmid = 11855986| year = 2002| last1 = Gohlke | first1 = H.| last2 = Gündisch| last3 = Schwarz| last4 = Seitz| last5 = Tilotta| last6 = Wegge| title = Synthesis and nicotinic binding studies on enantiopure diazine analogues of the novel (2-chloro-5-pyridyl)-9-azabicyclo4.2.1non-2-ene UB-165| volume = 45| issue = 5| pages = 1064–1072| journal = Journal of Medicinal Chemistry| doi = 10.1021/jm010936y}} 4. ^{{Cite journal| pmid = 12109907| year = 2002| last1 = Sharples | first1 = C. G.| last2 = Karig| last3 = Simpson| last4 = Spencer| last5 = Wright| last6 = Millar| last7 = Wonnacott| last8 = Gallagher| title = Synthesis and pharmacological characterization of novel analogues of the nicotinic acetylcholine receptor agonist (+/-)-UB-165| volume = 45| issue = 15| pages = 3235–3245| journal = Journal of Medicinal Chemistry| doi = 10.1021/jm020814l}} 5. ^{{Cite journal| last3 = Sharples | first1 = A.| first2 = T.| last2 = Gallagher| first3 = C.| first4 = S.| last1 = Sutherland| title = Synthesis of two fluoro analogues of the nicotinic acetylcholine receptor agonist UB-165| last4 = Wonnacott| journal = The Journal of Organic Chemistry| volume = 68| issue = 6| pages = 2475–2478| year = 2003| pmid = 12636420| doi = 10.1021/jo026698b}} 6. ^{{Cite journal| pmid = 14611837| year = 2003| last1 = Karig | first1 = G.| last2 = Large| last3 = Sharples| last4 = Sutherland| last5 = Gallagher| last6 = Wonnacott| title = Synthesis and nicotinic binding of novel phenyl derivatives of UB-165. Identifying factors associated with alpha7 selectivity| volume = 13| issue = 17| pages = 2825–2828| journal = Bioorganic & Medicinal Chemistry Letters| doi = 10.1016/S0960-894X(03)00594-8}} 5 : Nicotinic agonists|Stimulants|Pyridines|Chloroarenes|Nitrogen heterocycles |
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