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词条 UBE2N
释义

  1. Function

  2. Interactions

  3. References

  4. Further reading

{{Infobox_gene}}Ubiquitin-conjugating enzyme E2 N is a protein that in humans is encoded by the UBE2N gene.[1][2]

Function

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair.[2]

Interactions

UBE2N has been shown to interact with:

  • AURKA,[3]
  • HLTF,[4]
  • TRAF2,[5]
  • TRAF6,[5] and
  • UBE2V1.[5]

References

1. ^{{cite journal | vauthors = Yamaguchi T, Kim NS, Sekine S, Seino H, Osaka F, Yamao F, Kato S | title = Cloning and expression of cDNA encoding a human ubiquitin-conjugating enzyme similar to the Drosophila bendless gene product | journal = J Biochem | volume = 120 | issue = 3 | pages = 494–97 | date = February 1997 | pmid = 8902611 | pmc = | doi = 10.1093/oxfordjournals.jbchem.a021440 }}
2. ^1 {{cite web | title = Entrez Gene: UBE2N ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7334| accessdate = }}
3. ^{{cite journal | vauthors = Ewart-Toland A, Briassouli P, de Koning JP, Mao JH, Yuan J, Chan F, MacCarthy-Morrogh L, Ponder BA, Nagase H, Burn J, Ball S, Almeida M, Linardopoulos S, Balmain A | title = Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human | journal = Nat. Genet. | volume = 34 | issue = 4 | pages = 403–12 | date = August 2003 | pmid = 12881723 | doi = 10.1038/ng1220 }}
4. ^{{cite journal | vauthors = Unk I, Hajdú I, Fátyol K, Hurwitz J, Yoon JH, Prakash L, Prakash S, Haracska L | title = Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 105 | issue = 10 | pages = 3768–73 | date = March 2008 | pmid = 18316726 | pmc = 2268824 | doi = 10.1073/pnas.0800563105 }}
5. ^1 2 {{cite journal | vauthors = Deng L, Wang C, Spencer E, Yang L, Braun A, You J, Slaughter C, Pickart C, Chen ZJ | title = Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain | journal = Cell | volume = 103 | issue = 2 | pages = 351–61 | date = October 2000 | pmid = 11057907 | doi = 10.1016/s0092-8674(00)00126-4}}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery. | journal = Genome Res. | volume = 6 | issue = 9 | pages = 791–806 | year = 1997 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
  • {{cite journal | vauthors = Hofmann RM, Pickart CM | title = Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair. | journal = Cell | volume = 96 | issue = 5 | pages = 645–53 | year = 1999 | pmid = 10089880 | doi = 10.1016/S0092-8674(00)80575-9 }}
  • {{cite journal | vauthors = Deng L, Wang C, Spencer E, Yang L, Braun A, You J, Slaughter C, Pickart C, Chen ZJ | title = Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. | journal = Cell | volume = 103 | issue = 2 | pages = 351–61 | year = 2000 | pmid = 11057907 | doi = 10.1016/S0092-8674(00)00126-4 }}
  • {{cite journal | vauthors = Chan NL, Hill CP | title = Defining polyubiquitin chain topology. | journal = Nat. Struct. Biol. | volume = 8 | issue = 8 | pages = 650–2 | year = 2001 | pmid = 11473244 | doi = 10.1038/90337 }}
  • {{cite journal | vauthors = Moraes TF, Edwards RA, McKenna S, Pastushok L, Xiao W, Glover JN, Ellison MJ | title = Crystal structure of the human ubiquitin conjugating enzyme complex, hMms2-hUbc13. | journal = Nat. Struct. Biol. | volume = 8 | issue = 8 | pages = 669–73 | year = 2001 | pmid = 11473255 | doi = 10.1038/90373 }}
  • {{cite journal | vauthors = Ashley C, Pastushok L, McKenna S, Ellison MJ, Xiao W | title = Roles of mouse UBC13 in DNA postreplication repair and Lys63-linked ubiquitination. | journal = Gene | volume = 285 | issue = 1-2 | pages = 183–91 | year = 2002 | pmid = 12039045 | doi = 10.1016/S0378-1119(02)00409-2 }}
  • {{cite journal | vauthors = McKenna S, Moraes T, Pastushok L, Ptak C, Xiao W, Spyracopoulos L, Ellison MJ | title = An NMR-based model of the ubiquitin-bound human ubiquitin conjugation complex Mms2.Ubc13. The structural basis for lysine 63 chain catalysis. | journal = J. Biol. Chem. | volume = 278 | issue = 15 | pages = 13151–8 | year = 2003 | pmid = 12569095 | doi = 10.1074/jbc.M212353200 }}
  • {{cite journal | vauthors = Anandasabapathy N, Ford GS, Bloom D, Holness C, Paragas V, Seroogy C, Skrenta H, Hollenhorst M, Fathman CG, Soares L | title = GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells. | journal = Immunity | volume = 18 | issue = 4 | pages = 535–47 | year = 2003 | pmid = 12705856 | doi = 10.1016/S1074-7613(03)00084-0 }}
  • {{cite journal | vauthors = Ewart-Toland A, Briassouli P, de Koning JP, Mao JH, Yuan J, Chan F, MacCarthy-Morrogh L, Ponder BA, Nagase H, Burn J, Ball S, Almeida M, Linardopoulos S, Balmain A | title = Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human. | journal = Nat. Genet. | volume = 34 | issue = 4 | pages = 403–12 | year = 2003 | pmid = 12881723 | doi = 10.1038/ng1220 }}
  • {{cite journal | vauthors = Bothos J, Summers MK, Venere M, Scolnick DM, Halazonetis TD | title = The Chfr mitotic checkpoint protein functions with Ubc13-Mms2 to form Lys63-linked polyubiquitin chains. | journal = Oncogene | volume = 22 | issue = 46 | pages = 7101–7 | year = 2003 | pmid = 14562038 | doi = 10.1038/sj.onc.1206831 }}
  • {{cite journal | vauthors = Zhou H, Wertz I, O'Rourke K, Ultsch M, Seshagiri S, Eby M, Xiao W, Dixit VM | title = Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO. | journal = Nature | volume = 427 | issue = 6970 | pages = 167–71 | year = 2004 | pmid = 14695475 | doi = 10.1038/nature02273 }}
  • {{cite journal | vauthors = Sun L, Deng L, Ea CK, Xia ZP, Chen ZJ | title = The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes. | journal = Mol. Cell | volume = 14 | issue = 3 | pages = 289–301 | year = 2004 | pmid = 15125833 | doi = 10.1016/S1097-2765(04)00236-9 }}
  • {{cite journal | vauthors = Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM | title = Functional proteomics mapping of a human signaling pathway. | journal = Genome Res. | volume = 14 | issue = 7 | pages = 1324–32 | year = 2004 | pmid = 15231748 | pmc = 442148 | doi = 10.1101/gr.2334104 }}
  • {{cite journal | vauthors = Pastushok L, Moraes TF, Ellison MJ, Xiao W | title = A single Mms2 "key" residue insertion into a Ubc13 pocket determines the interface specificity of a human Lys63 ubiquitin conjugation complex. | journal = J. Biol. Chem. | volume = 280 | issue = 18 | pages = 17891–900 | year = 2005 | pmid = 15749714 | doi = 10.1074/jbc.M410469200 }}
  • {{cite journal | vauthors = Takeuchi T, Yokosawa H | title = ISG15 modification of Ubc13 suppresses its ubiquitin-conjugating activity. | journal = Biochem. Biophys. Res. Commun. | volume = 336 | issue = 1 | pages = 9–13 | year = 2005 | pmid = 16112642 | doi = 10.1016/j.bbrc.2005.08.034 }}
  • {{cite journal | vauthors = Zou W, Papov V, Malakhova O, Kim KI, Dao C, Li J, Zhang DE | title = ISG15 modification of ubiquitin E2 Ubc13 disrupts its ability to form thioester bond with ubiquitin. | journal = Biochem. Biophys. Res. Commun. | volume = 336 | issue = 1 | pages = 61–8 | year = 2005 | pmid = 16122702 | doi = 10.1016/j.bbrc.2005.08.038 }}
{{refend}}{{PDB Gallery|geneid=7334}}{{Ubiquitin-conjugating enzymes}}{{gene-12-stub}}
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