1. Function

2. Interactions

3. References

4. Further reading

Function

Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene is located in the nucleus and can cause transcriptional activation of the human FOS proto-oncogene. It is thought to be involved in the control of differentiation by altering cell cycle behavior. Multiple alternatively spliced transcripts encoding different isoforms have been described for this gene. A pseudogene has been identified which is also located on chromosome 20. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (Kua-UEV), which encodes a fusion protein consisting of sequence sharing identity with each individual gene product.^[3]

Interactions

UBE2V1 has been shown to interact with UBE2N.^[4]

References

Further reading

• {{cite journal | vauthors = Long M | title = A new function evolved from gene fusion. | journal = Genome Res. | volume = 10 | issue = 11 | pages = 1655–7 | year = 2001 | pmid = 11076848 | doi = 10.1101/gr.165700 }}
• {{cite journal | vauthors = Thomson TM, Khalid H, Lozano JJ, Sancho E, Ariño J | title = Role of UEV-1A, a homologue of the tumor suppressor protein TSG101, in protection from DNA damage. | journal = FEBS Lett. | volume = 423 | issue = 1 | pages = 49–52 | year = 1998 | pmid = 9580084 | doi = 10.1016/S0014-5793(98)00060-X }}
• {{cite journal | vauthors = Xiao W, Lin SL, Broomfield S, Chow BL, Wei YF | title = The products of the yeast MMS2 and two human homologs (hMMS2 and CROC-1) define a structurally and functionally conserved Ubc-like protein family. | journal = Nucleic Acids Res. | volume = 26 | issue = 17 | pages = 3908–14 | year = 1998 | pmid = 9705497 | pmc = 147796 | doi = 10.1093/nar/26.17.3908 }}
• {{cite journal | vauthors = Ma L, Broomfield S, Lavery C, Lin SL, Xiao W, Bacchetti S | title = Up-regulation of CIR1/CROC1 expression upon cell immortalization and in tumor-derived human cell lines. | journal = Oncogene | volume = 17 | issue = 10 | pages = 1321–6 | year = 1998 | pmid = 9771976 | doi = 10.1038/sj.onc.1202058 }}
• {{cite journal | vauthors = Hofmann RM, Pickart CM | title = Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair. | journal = Cell | volume = 96 | issue = 5 | pages = 645–53 | year = 1999 | pmid = 10089880 | doi = 10.1016/S0092-8674(00)80575-9 }}
• {{cite journal | vauthors = Deng L, Wang C, Spencer E, Yang L, Braun A, You J, Slaughter C, Pickart C, Chen ZJ | title = Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. | journal = Cell | volume = 103 | issue = 2 | pages = 351–61 | year = 2000 | pmid = 11057907 | doi = 10.1016/S0092-8674(00)00126-4 }}
• {{cite journal | vauthors = Thomson TM, Lozano JJ, Loukili N, Carrió R, Serras F, Cormand B, Valeri M, Díaz VM, Abril J, Burset M, Merino J, Macaya A, Corominas M, Guigó R | title = Fusion of the human gene for the polyubiquitination coeffector UEV1 with Kua, a newly identified gene. | journal = Genome Res. | volume = 10 | issue = 11 | pages = 1743–56 | year = 2001 | pmid = 11076860 | pmc = 310942 | doi = 10.1101/gr.GR-1405R }}
• {{cite journal | vauthors = Ito M, Shichijo S, Tsuda N, Ochi M, Harashima N, Saito N, Itoh K | title = Molecular basis of T cell-mediated recognition of pancreatic cancer cells. | journal = Cancer Res. | volume = 61 | issue = 5 | pages = 2038–46 | year = 2001 | pmid = 11280764 | doi = }}
• {{cite journal | vauthors = Andersen PL, Zhou H, Pastushok L, Moraes T, McKenna S, Ziola B, Ellison MJ, Dixit VM, Xiao W | title = Distinct regulation of Ubc13 functions by the two ubiquitin-conjugating enzyme variants Mms2 and Uev1A. | journal = J. Cell Biol. | volume = 170 | issue = 5 | pages = 745–55 | year = 2005 | pmid = 16129784 | pmc = 2171356 | doi = 10.1083/jcb.200502113 }}
• {{cite journal | vauthors = Hau DD, Lewis MJ, Saltibus LF, Pastushok L, Xiao W, Spyracopoulos L | title = Structure and interactions of the ubiquitin-conjugating enzyme variant human Uev1a: implications for enzymatic synthesis of polyubiquitin chains. | journal = Biochemistry | volume = 45 | issue = 32 | pages = 9866–77 | year = 2006 | pmid = 16893187 | doi = 10.1021/bi060631r }}
• {{cite journal | vauthors = Syed NA, Andersen PL, Warrington RC, Xiao W | title = Uev1A, a ubiquitin conjugating enzyme variant, inhibits stress-induced apoptosis through NF-kappaB activation. | journal = Apoptosis | volume = 11 | issue = 12 | pages = 2147–57 | year = 2007 | pmid = 17041755 | doi = 10.1007/s10495-006-0197-3 }}
• {{cite journal | vauthors = Petroski MD, Zhou X, Dong G, Daniel-Issakani S, Payan DG, Huang J | title = Substrate modification with lysine 63-linked ubiquitin chains through the UBC13-UEV1A ubiquitin-conjugating enzyme. | journal = J. Biol. Chem. | volume = 282 | issue = 41 | pages = 29936–45 | year = 2007 | pmid = 17709375 | doi = 10.1074/jbc.M703911200 }}

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