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词条 UBQLN1
释义

  1. Possible Role In Preventing Alzheimers Disease

  2. Similarity to Other Proteins

  3. Interactions

  4. References

  5. Further reading

{{Infobox_gene}}Ubiquilin-1 is a protein that in humans is encoded by the UBQLN1 gene.[1][2][3]

Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to effect in vivo protein degradation.

Possible Role In Preventing Alzheimers Disease

Ubiquilin has also been shown to modulate accumulation of presenilin proteins, and is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene.[3]

Higher levels of ubiquilin-1 in the brain decreased malformation of the APP molecule which plays a key role in triggering Alzheimers disease.[4] Conversely, lower levels of ubiquilin-1 in the brain were associated with increased malformation of APP.[4]

Similarity to Other Proteins

Human UBQLN1 shares a high degree of similarity with related ubiquilins including UBQLN2 and UBQLN4.[5]

Interactions

UBQLN1 has been shown to interact with

  • HERPUD1,[6]
  • MTOR,[7]
  • P4HB,[8]
  • PSEN1[9]
  • PSEN2,[9] and
  • UBE3A.[10]
  • TMCO6,[11]

References

1. ^{{cite journal | vauthors = Ozaki T, Hishiki T, Toyama Y, Yuasa S, Nakagawara A, Sakiyama S | title = Identification of a new cellular protein that can interact specifically with DAN | journal = DNA Cell Biol | volume = 16 | issue = 8 | pages = 985–91 |date=Oct 1997 | pmid = 9303440 | pmc = | doi =10.1089/dna.1997.16.985 }}
2. ^{{cite journal | vauthors = Hanaoka E, Ozaki T, Ohira M, Nakamura Y, Suzuki M, Takahashi E, Moriya H, Nakagawara A, Sakiyama S | title = Molecular cloning and expression analysis of the human DA41 gene and its mapping to chromosome 9q21.2-q21.3 | journal = J Hum Genet | volume = 45 | issue = 3 | pages = 188–91 |date=Jul 2000 | pmid = 10807547 | pmc = | doi = 10.1007/s100380050209 }}
3. ^1 {{cite web | title = Entrez Gene: UBQLN1 ubiquilin 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29979| accessdate = }}
4. ^1 {{cite journal | vauthors = Stieren ES, El Ayadi A, Xiao Y, Siller E, Landsverk ML, Oberhauser AF, Barral JM, Boehning D | title = Ubiquilin-1 Is a Molecular Chaperone for the Amyloid Precursor Protein | journal = J Biol Chem | volume = 286| issue = 41| pages = 35689–98|date=August 2011 | pmid = 21852239 | doi = 10.1074/jbc.M111.243147 | laysummary = https://www.sciencedaily.com/releases/2011/09/110901112537.htm | laysource = Science Daily | pmc=3195644}}
5. ^{{cite journal | author = Marín I | title = The ubiquilin gene family: evolutionary patterns and functional insights | journal = BMC Evol Biol | volume = 14| pages = 63 | date=March 2014 | pmid = 24674348 | doi = 10.1186/1471-2148-14-63 | pmc=4230246}}
6. ^{{cite journal | vauthors = Kim TY, Kim E, Yoon SK, Yoon JB | title = Herp enhances ER-associated protein degradation by recruiting ubiquilins | journal = Biochem. Biophys. Res. Commun. | volume = 369 | issue = 2 | pages = 741–6 |date=May 2008 | pmid = 18307982 | doi = 10.1016/j.bbrc.2008.02.086 }}
7. ^{{cite journal | vauthors = Wu S, Mikhailov A, Kallo-Hosein H, Hara K, Yonezawa K, Avruch J | title = Characterization of ubiquilin 1, an mTOR-interacting protein | journal = Biochim. Biophys. Acta | volume = 1542 | issue = 1–3 | pages = 41–56 |date=January 2002 | pmid = 11853878 | doi = 10.1016/S0167-4889(01)00164-1 }}
8. ^{{cite journal | vauthors = Ko HS, Uehara T, Nomura Y | title = Role of ubiquilin associated with protein-disulfide isomerase in the endoplasmic reticulum in stress-induced apoptotic cell death | journal = J. Biol. Chem. | volume = 277 | issue = 38 | pages = 35386–92 |date=September 2002 | pmid = 12095988 | doi = 10.1074/jbc.M203412200 }}
9. ^1 {{cite journal | vauthors = Mah AL, Perry G, Smith MA, Monteiro MJ | title = Identification of Ubiquilin, a Novel Presenilin Interactor That Increases Presenilin Protein Accumulation | journal = J. Cell Biol. | volume = 151 | issue = 4 | pages = 847–62 |date=November 2000 | pmid = 11076969 | pmc = 2169435 | doi = 10.1083/jcb.151.4.847 }}
10. ^{{cite journal | vauthors = Kleijnen MF, Shih AH, Zhou P, Kumar S, Soccio RE, Kedersha NL, Gill G, Howley PM | title = The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome | journal = Mol. Cell | volume = 6 | issue = 2 | pages = 409–19 |date=August 2000 | pmid = 10983987 | doi = 10.1016/S1097-2765(00)00040-X }}
11. ^{{cite journal | pmid = 25416956 | doi=10.1016/j.cell.2014.10.050 | pmc=4266588 | volume=159 | title=A proteome-scale map of the human interactome network | year=2014 | journal=Cell | pages=1212–26 | vauthors=Rolland T, Taşan M, Charloteaux B, Pevzner SJ, Zhong Q, Sahni N, Yi S, Lemmens I, Fontanillo C, Mosca R, Kamburov A, Ghiassian SD, Yang X, Ghamsari L, Balcha D, Begg BE, Braun P, Brehme M, Broly MP, Carvunis AR, Convery-Zupan D, Corominas R, Coulombe-Huntington J, Dann E, Dreze M, Dricot A, Fan C, Franzosa E, Gebreab F, Gutierrez BJ, Hardy MF, Jin M, Kang S, Kiros R, Lin GN, Luck K, MacWilliams A, Menche J, Murray RR, Palagi A, Poulin MM, Rambout X, Rasla J, Reichert P, Romero V, Ruyssinck E, Sahalie JM, Scholz A, Shah AA, Sharma A, Shen Y, Spirohn K, Tam S, Tejeda AO, Trigg SA, Twizere JC, Vega K, Walsh J, Cusick ME, Xia Y, Barabási AL, Iakoucheva LM, Aloy P, De Las RJ, Tavernier J, Calderwood MA, Hill DE, Hao T, Roth FP, Vidal M}}

Further reading

{{refbegin | 2}}
  • {{cite journal |vauthors=Ozaki T, Kondo K, Nakamura Y, etal |title=Interaction of DA41, a DAN-binding protein, with the epidermal growth factor-like protein, S(1-5) |journal=Biochem. Biophys. Res. Commun. |volume=237 |issue= 2 |pages= 245–50 |year= 1997 |pmid= 9268694 |doi= 10.1006/bbrc.1997.7122 }}
  • {{cite journal |vauthors=Ozaki T, Hanaoka E, Naka M, etal |title=Cloning and characterization of rat BAT3 cDNA |journal=DNA Cell Biol. |volume=18 |issue= 6 |pages= 503–12 |year= 1999 |pmid= 10390159 |doi= 10.1089/104454999315222 }}
  • {{cite journal | vauthors=Wu AL, Wang J, Zheleznyak A, Brown EJ |title=Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane |journal=Mol. Cell |volume=4 |issue= 4 |pages= 619–25 |year= 1999 |pmid= 10549293 |doi=10.1016/S1097-2765(00)80212-9 }}
  • {{cite journal |vauthors=Kleijnen MF, Shih AH, Zhou P, etal |title=The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome |journal=Mol. Cell |volume=6 |issue= 2 |pages= 409–19 |year= 2000 |pmid= 10983987 |doi=10.1016/S1097-2765(00)00040-X }}
  • {{cite journal | vauthors=Mah AL, Perry G, Smith MA, Monteiro MJ |title=Identification of Ubiquilin, a Novel Presenilin Interactor That Increases Presenilin Protein Accumulation |journal=J. Cell Biol. |volume=151 |issue= 4 |pages= 847–62 |year= 2000 |pmid= 11076969 |doi=10.1083/jcb.151.4.847 | pmc=2169435 }}
  • {{cite journal |vauthors=Wiemann S, Weil B, Wellenreuther R, etal |title=Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R | pmc=311072 }}
  • {{cite journal |vauthors=Simpson JC, Wellenreuther R, Poustka A, etal |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 | pmc=1083732 }}
  • {{cite journal |vauthors=Bedford FK, Kittler JT, Muller E, etal |title=GABA(A) receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1 |journal=Nat. Neurosci. |volume=4 |issue= 9 |pages= 908–16 |year= 2001 |pmid= 11528422 |doi= 10.1038/nn0901-908 }}
  • {{cite journal |vauthors=Wu S, Mikhailov A, Kallo-Hosein H, etal |title=Characterization of ubiquilin 1, an mTOR-interacting protein |journal=Biochim. Biophys. Acta |volume=1542 |issue= 1–3 |pages= 41–56 |year= 2002 |pmid= 11853878 |doi=10.1016/S0167-4889(01)00164-1 }}
  • {{cite journal | vauthors=Ko HS, Uehara T, Nomura Y |title=Role of ubiquilin associated with protein-disulfide isomerase in the endoplasmic reticulum in stress-induced apoptotic cell death |journal=J. Biol. Chem. |volume=277 |issue= 38 |pages= 35386–92 |year= 2002 |pmid= 12095988 |doi= 10.1074/jbc.M203412200 }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
  • {{cite journal |vauthors=Gao L, Tu H, Shi ST, etal |title=Interaction with a Ubiquitin-Like Protein Enhances the Ubiquitination and Degradation of Hepatitis C Virus RNA-Dependent RNA Polymerase |journal=J. Virol. |volume=77 |issue= 7 |pages= 4149–59 |year= 2003 |pmid= 12634373 |doi=10.1128/JVI.77.7.4149-4159.2003 | pmc=150629 }}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
  • {{cite journal |vauthors=Massey LK, Mah AL, Ford DL, etal |title=Overexpression of ubiquilin decreases ubiquitination and degradation of presenilin proteins |journal=J. Alzheimers Dis. |volume=6 |issue= 1 |pages= 79–92 |year= 2004 |pmid= 15004330 |doi= }}
  • {{cite journal |vauthors=Colland F, Jacq X, Trouplin V, etal |title=Functional Proteomics Mapping of a Human Signaling Pathway |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 | pmc=442148 }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{cite journal | vauthors=Persson P, Stockhausen MT, Påhlman S, Axelson H |title=Ubiquilin-1 is a novel HASH-1-complexing protein that regulates levels of neuronal bHLH transcription factors in human neuroblastoma cells |journal=Int. J. Oncol. |volume=25 |issue= 5 |pages= 1213–21 |year= 2005 |pmid= 15492808 |doi= 10.3892/ijo.25.5.1213}}
  • {{cite journal |vauthors=Bertram L, Hiltunen M, Parkinson M, etal |title=Family-based association between Alzheimer's disease and variants in UBQLN1 |journal=N. Engl. J. Med. |volume=352 |issue= 9 |pages= 884–94 |year= 2005 |pmid= 15745979 |doi= 10.1056/NEJMoa042765 }}
{{refend}}
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