“UDP-glucose—hexose-1-phosphate uridylyltransferase”的意思、由来-开放百科全书

词条

UDP-glucose—hexose-1-phosphate uridylyltransferase

释义

Structural studies
References

{{enzyme
| Name = UDP-glucose:hexose-1-phosphate uridylyltransferase
| EC_number = 2.7.7.12
| CAS_number = 9026-21-5
| IUBMB_EC_number = 2/7/7/12
| GO_code = 0008108
| image =
| width =
| caption =
}}{{Orphan|date=February 2009}}

In enzymology, an UDP-glucose—hexose-1-phosphate uridylyltransferase ({{EC number|2.7.7.12}}) is an enzyme that catalyzes the chemical reaction

UDP-glucose + alpha-D-galactose 1-phosphate alpha-D-glucose 1-phosphate + UDP-galactose

Thus, the two substrates of this enzyme are UDP-glucose and alpha-D-galactose 1-phosphate, whereas its two products are alpha-D-glucose 1-phosphate and UDP-galactose.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is UDP-glucose:alpha-D-galactose-1-phosphate uridylyltransferase. Other names in common use include uridyl transferase, hexose-1-phosphate uridylyltransferase, uridyltransferase, and hexose 1-phosphate uridyltransferase. This enzyme participates in galactose metabolism and nucleotide sugars metabolism.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1HXQ}}, {{PDB link|2H39}}, {{PDB link|2Q4H}}, and {{PDB link|2Q4L}}.

References

{{cite journal | vauthors = KALCKAR HM, BRAGANCA B, MUNCH-PETERSEN HM | year = 1953 | title = Uridyl transferases and the formation of uridine diphosphogalactose | journal = Nature | volume = 172 | pages = 1038 | pmid = 13111247 | doi = 10.1038/1721038a0 | issue = 4388 }}
{{cite journal | vauthors = KURAHASHI K, SUGIMURA A | year = 1960 | title = Purification and properties of galactose 1-phosphate uridyl transferase from Escherichia coli | journal = J. Biol. Chem. | volume = 235 | pages = 940–6 | pmid = 14412847 }}
{{cite journal |author1 = Mayes JS |author2 =Hansen RG | year = 1966 | title = Galactose 1-phosphate uridyl transferase | journal = Methods Enzymol. | volume = 9 | pages = 708–713 | doi = 10.1016/0076-6879(66)09143-2 }}
{{cite journal | vauthors = Saito S, Ozutsumi M, Kurahashi K | year = 1967 | title = Galactose 1-phosphate uridylyltransferase of Escherichia coli. II Further purification and characterization | journal = J. Biol. Chem. | volume = 242 | pages = 2362–8 | pmid = 5338129 | issue = 10 }}
{{cite journal | vauthors = SMITH EE, MILLS GT | year = 1955 | title = The uridyl transferase of mammary gland | journal = Biochim. Biophys. Acta | volume = 18 | pages = 152 | pmid = 13260264 | doi = 10.1016/0006-3002(55)90029-9 | issue = 1 }}

{{Kinases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{DEFAULTSORT:UDP-glucose-hexose-1-phosphate uridylyltransferase}}{{2.7-enzyme-stub}}

2 : EC 2.7.7|Enzymes of known structure

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