“UDP-N-acetylglucosamine diphosphorylase”的意思、由来-开放百科全书

词条

UDP-N-acetylglucosamine diphosphorylase

释义

Nomenclature
References

{{enzyme
| Name = UDP-N-acetylglucosamine diphosphorylase
| EC_number = 2.7.7.23
| CAS_number = 9023-06-7
| IUBMB_EC_number = 2/7/7/23
| GO_code = 0003977
| image =
| width =
| caption =
}}

In enzymology, an UDP-N-acetylglucosamine diphosphorylase ({{EC number|2.7.7.23}}) is an enzyme that catalyzes the chemical reaction

UTP + N-acetyl-alpha-D-glucosamine 1-phosphate diphosphate + UDP-N-acetyl-D-glucosamine

Thus, the two substrates of this enzyme are UTP and[N-acetyl-alpha-D-glucosamine 1-phosphate, whereas its two products are diphosphate and UDP-N-acetyl-D-glucosamine. This enzyme participates in aminosugars metabolism.

Nomenclature

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is UTP:N-acetyl-alpha-D-glucosamine-1-phosphate uridylyltransferase. Other names in common use include UDP-N-acetylglucosamine pyrophosphorylase, uridine diphosphoacetylglucosamine pyrophosphorylase, UTP:2-acetamido-2-deoxy-alpha-D-glucose-1-phosphate, uridylyltransferase, UDP-GlcNAc pyrophosphorylase, GlmU uridylyltransferase, Acetylglucosamine 1-phosphate uridylyltransferase, UDP-acetylglucosamine pyrophosphorylase, uridine diphosphate-N-acetylglucosamine pyrophosphorylase, uridine diphosphoacetylglucosamine phosphorylase, and acetylglucosamine 1-phosphate uridylyltransferase.

References

{{cite journal | vauthors = Pattabiraman TN, Bachhawat BK | title = Purification of uridine diphosphoacetylglucosamine pyrophosphorylase from sheep brain | journal = Biochimica et Biophysica Acta | volume = 50 | pages = 129–34 | date = June 1961 | pmid = 13733356 | doi = 10.1016/0006-3002(61)91068-X }}
{{cite journal | vauthors = Strominger JL, Smith MS | date = 1959 | title = Uridine diphosphoacetylglucosamine pyrophosphorylase | journal = J. Biol. Chem. | volume = 234 | pages = 1822–1827 | pmid = 13672971 }}

2 : EC 2.7.7|Enzymes of known structure

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