“UDP-sugar diphosphatase”的意思、由来-开放百科全书

词条

UDP-sugar diphosphatase

释义

Structural studies
References

{{enzyme
| Name = UDP-sugar diphosphatase
| EC_number = 3.6.1.45
| CAS_number = 57127-20-5
| IUBMB_EC_number = 3/6/1/45
| GO_code = 0008768
| image =
| width =
| caption =
}}

In enzymology, an UDP-sugar diphosphatase ({{EC number|3.6.1.45}}) is an enzyme that catalyzes the chemical reaction

UDP-sugar + H₂O UMP + alpha-D-aldose 1-phosphate

Thus, the two substrates of this enzyme are UDP-sugar and H₂O, whereas its two products are UMP and alpha-D-aldose 1-phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is UDP-sugar sugarphosphohydrolase. Other names in common use include nucleosidediphosphate-sugar pyrophosphatase, nucleosidediphosphate-sugar diphosphatase, UDP-sugar hydrolase, and UDP-sugar pyrophosphatase.

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1HO5}}, {{PDB link|1HP1}}, {{PDB link|1HPU}}, {{PDB link|1OI8}}, {{PDB link|1OID}}, and {{PDB link|1OIE}}.

References

{{cite journal | vauthors = Garrett AR, Johnson LA, Beacham IR | date = 1989 | title = Isolation, molecular characterization and expression of the ushB gene of Salmonella typhimurium which encodes a membrane-bound UDP-sugar hydrolase | journal = Mol. Microbiol. | volume = 3 | pages = 177–86 | pmid = 2548058 | doi = 10.1111/j.1365-2958.1989.tb01806.x | issue = 2 }}
{{cite journal | vauthors = Glaser L, Melo A, Paul R | date = 1987 | title = Uridine diphosphate sugar hydrolase. Purification of enzyme and protein inhibitor | journal = J. Biol. Chem. | volume = 242 | pages = 1944–1954 | pmid=5337593 | issue = 8}}

2 : EC 3.6.1|Enzymes of known structure

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