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词条 USP18
释义

  1. References

  2. Further reading

{{Infobox_gene}}Ubiquitin specific peptidase 18 (USP18), also known as UBP43, is an isopeptidase that in human is encoded by the USP18 gene.[1] USP18 is a member of the deubiquitinating protease family of enzymes. It is thought to remove ISG15 adducts from a broad range of protein substrates, a process known as deISGylation.[1] In mice, deletion of this enzyme results in increased inflammatory response to type I interferons, suggesting that USP18 may, in part, regulate interferon responsiveness.[2]

References

1. ^{{cite web | title = Entrez Gene: USP18 ubiquitin specific peptidase 18| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11274| accessdate = }}
2. ^{{Cite web|url=https://www.ncbi.nlm.nih.gov/gene/11274|title=USP18 ubiquitin specific peptidase 18 [Homo sapiens (human)] - Gene - NCBI|website=www.ncbi.nlm.nih.gov|access-date=2018-01-03}}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Li XL, Blackford JA, Judge CS, Liu M, Xiao W, Kalvakolanu DV, Hassel BA | title = RNase-L-dependent destabilization of interferon-induced mRNAs. A role for the 2-5A system in attenuation of the interferon response | journal = The Journal of Biological Chemistry | volume = 275 | issue = 12 | pages = 8880–8 | date = March 2000 | pmid = 10722734 | doi = 10.1074/jbc.275.12.8880 }}
  • {{cite journal | vauthors = Schwer H, Liu LQ, Zhou L, Little MT, Pan Z, Hetherington CJ, Zhang DE | title = Cloning and characterization of a novel human ubiquitin-specific protease, a homologue of murine UBP43 (Usp18) | journal = Genomics | volume = 65 | issue = 1 | pages = 44–52 | date = April 2000 | pmid = 10777664 | doi = 10.1006/geno.2000.6148 }}
  • {{cite journal | vauthors = Kang D, Jiang H, Wu Q, Pestka S, Fisher PB | title = Cloning and characterization of human ubiquitin-processing protease-43 from terminally differentiated human melanoma cells using a rapid subtraction hybridization protocol RaSH | journal = Gene | volume = 267 | issue = 2 | pages = 233–42 | date = April 2001 | pmid = 11313150 | doi = 10.1016/S0378-1119(01)00384-5 }}
  • {{cite journal | vauthors = Malakhov MP, Malakhova OA, Kim KI, Ritchie KJ, Zhang DE | title = UBP43 (USP18) specifically removes ISG15 from conjugated proteins | journal = The Journal of Biological Chemistry | volume = 277 | issue = 12 | pages = 9976–81 | date = March 2002 | pmid = 11788588 | doi = 10.1074/jbc.M109078200 }}
  • {{cite journal | vauthors = Tokarz S, Berset C, La Rue J, Friedman K, Nakayama K, Nakayama K, Zhang DE, Lanker S | title = The ISG15 isopeptidase UBP43 is regulated by proteolysis via the SCFSkp2 ubiquitin ligase | journal = The Journal of Biological Chemistry | volume = 279 | issue = 45 | pages = 46424–30 | date = November 2004 | pmid = 15342634 | doi = 10.1074/jbc.M403189200 }}
  • {{cite journal | vauthors = Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A | title = From ORFeome to biology: a functional genomics pipeline | journal = Genome Research | volume = 14 | issue = 10B | pages = 2136–44 | date = October 2004 | pmid = 15489336 | pmc = 528930 | doi = 10.1101/gr.2576704 }}
  • {{cite journal | vauthors = Yan M, Luo JK, Ritchie KJ, Sakai I, Takeuchi K, Ren R, Zhang DE | title = Ubp43 regulates BCR-ABL leukemogenesis via the type 1 interferon receptor signaling | journal = Blood | volume = 110 | issue = 1 | pages = 305–12 | date = July 2007 | pmid = 17374743 | pmc = 1896118 | doi = 10.1182/blood-2006-07-033209 }}
  • {{cite journal | vauthors = Ketscher L, Hannß R, Morales DJ, Basters A, Guerra S, Goldmann T, Hausmann A, Prinz M, Naumann R, Pekosz A, Utermöhlen O, Lenschow DJ, Knobeloch KP | title = Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 112 | issue = 5 | pages = 1577–82 | date = February 2015 | pmid = 25605921 | pmc = 4321242 | doi = 10.1073/pnas.1412881112 | url = https://repositorio.uam.es/bitstream/10486/672352/1/selective_ketscher_PNAS_2015.pdf }}
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