| 释义 |
- References
- Further reading
{{Infobox_gene}}Ubiquitin carboxyl-terminal hydrolase 48 is an enzyme that in humans is encoded by the USP48 gene.[1][2]{{PBB_Summary
| section_title =
| summary_text = This gene encodes a protein containing domains that associate it with the peptidase family C19, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. Family members function as deubiquitinating enzymes, recognizing and hydrolyzing the peptide bond at the C-terminal glycine of ubiquitin. Enzymes in peptidase family C19 are involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[2]In melanocytic cells USP48 gene expression may be regulated by MITF.[3]
}}References1. ^{{cite journal | vauthors = Puente XS, Sanchez LM, Overall CM, Lopez-Otin C | title = Human and mouse proteases: a comparative genomic approach | journal = Nat Rev Genet | volume = 4 | issue = 7 | pages = 544–58 |date=Jul 2003 | pmid = 12838346 | pmc = | doi = 10.1038/nrg1111 }}
2. ^1 {{cite web | title = Entrez Gene: USP48 ubiquitin specific peptidase 48| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84196| accessdate = }}
3. ^{{cite journal |vauthors=Hoek KS, Schlegel NC, Eichhoff OM, et al. | title = Novel MITF targets identified using a two-step DNA microarray strategy | journal = Pigment Cell Melanoma Res. | volume = 21 | issue = 6 | pages = 665–76 | year = 2008 | pmid = 19067971 | doi = 10.1111/j.1755-148X.2008.00505.x }}
Further reading{{refbegin | 2}}- {{cite journal | author=Wilkinson KD |title=Regulation of ubiquitin-dependent processes by deubiquitinating enzymes. |journal=FASEB J. |volume=11 |issue= 14 |pages= 1245–56 |year= 1998 |pmid= 9409543 |doi= }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
- {{cite journal |vauthors=Quesada V, Díaz-Perales A, Gutiérrez-Fernández A, etal |title=Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. |journal=Biochem. Biophys. Res. Commun. |volume=314 |issue= 1 |pages= 54–62 |year= 2004 |pmid= 14715245 |doi=10.1016/j.bbrc.2003.12.050 }}
- {{cite journal |vauthors=Suzuki Y, Yamashita R, Shirota M, etal |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 | pmc=515316 }}
- {{cite journal |vauthors=Lockhart PJ, Hulihan M, Lincoln S, etal |title=Identification of the human ubiquitin specific protease 31 (USP31) gene: structure, sequence and expression analysis. |journal=DNA Seq. |volume=15 |issue= 1 |pages= 9–14 |year= 2004 |pmid= 15354349 |doi= 10.1080/10855660310001638197}}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Tzimas C, Michailidou G, Arsenakis M, etal |title=Human ubiquitin specific protease 31 is a deubiquitinating enzyme implicated in activation of nuclear factor-kappaB. |journal=Cell. Signal. |volume=18 |issue= 1 |pages= 83–92 |year= 2006 |pmid= 16214042 |doi= 10.1016/j.cellsig.2005.03.017 }}
- {{cite journal |vauthors=Gregory SG, Barlow KF, McLay KE, etal |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
- {{cite journal |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
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