请输入您要查询的百科知识:

 

词条 MVA85A
释义

  1. References

  2. External links

MVA85A (modified vaccinia Ankara 85A) is a new-generation vaccine against tuberculosis developed by researchers at Oxford University. This vaccine produces higher levels of long-lasting cellular immunity when used together with the older TB vaccine BCG.[1] Phase I clinical trials have been completed[2] and phase II clinical trials are currently underway in South Africa.[3] As of late 2010, those trials, while promising, were not expected to be finished until late 2015, with efficacy trials running in parallel from 2009 to 2019.[4] By contrast, results released in February 2013 were described as "disappointing", showing only a statistically insignificant prevention rate in infants.[5]

Results published in 2015 bring the further doubt on the efficacy of the vaccine.[6]

References

1. ^{{cite journal |vauthors=McShane H, Pathan AA, Sander CR, etal | title=Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG primed and naturally acquired anti-microbial immunity in humans | journal=Nat Med | year=2004 | volume=10 | pages=1240–44 | doi=10.1038/nm1128 | pmid=15502839 | issue=11 }}
2. ^{{cite journal|vauthors=Hawkridge T, Scriba TJ, Gelderbloem S, et al.|title=Safety and immunogenicity of a new tuberculosis vaccine, MVA85A, in healthy adults in South Africa|journal=J Infect Dis|year=2008|volume=198|pages=544–52|doi=10.1086/590185|pmid=18582195|issue=4|pmc=2822902|display-authors=etal}}
3. ^{{cite journal |vauthors=Ibanga H, Brookes R, Hill P, Owiafe P, Fletcher H, Lienhardt C, Hill A, Adegbola R, McShane H |title=Early clinical trials with a new tuberculosis vaccine, MVA85A, in tuberculosis-endemic countries: issues in study design |journal=Lancet Infect Dis |volume=6 |issue=8 |pages=522–8 |year=2006 |pmid=16870530 |doi=10.1016/S1473-3099(06)70552-7}}
4. ^{{cite web|url=http://www.tbvaccine2010.org/uploads/McShane__Helen_-_Thursday__September_23rd.pdf|title=Improving BCG with MVA85A: An update on clinical trials|publisher=The Jenner Institute|author=McShane H|accessdate=2 October 2012|date=23 September 2010}}
5. ^{{cite web|title=Tuberculosis vaccine hopes dashed|url=https://www.bbc.co.uk/news/health-21302518|first=Fergus|last=Walsh|publisher=BBC News|date=4 February 2013|accessdate=4 February 2013}}
6. ^{{cite web|url=http://ije.oxfordjournals.org/content/early/2015/09/05/ije.dyv142.short?rss=1 |title=Effects of MVA85A vaccine on tuberculosis challenge in animals: systematic review |publisher=Ije.oxfordjournals.org |date= |accessdate=2015-09-09}}

External links

  • New TB vaccine shown to be safe
{{Vaccines}}{{DEFAULTSORT:Mva85a}}{{vaccine-stub}}

1 : Tuberculosis vaccines

随便看

 

开放百科全书收录14589846条英语、德语、日语等多语种百科知识,基本涵盖了大多数领域的百科知识,是一部内容自由、开放的电子版国际百科全书。

 

Copyright © 2023 OENC.NET All Rights Reserved
京ICP备2021023879号 更新时间:2024/9/23 22:43:25