“UTP—hexose-1-phosphate uridylyltransferase”的意思、由来-开放百科全书

词条

UTP—hexose-1-phosphate uridylyltransferase

释义

Enzyme family
Structural studies
References

{{enzyme
| Name = UTP:galactose-1-phosphate uridylyltransferase
| EC_number = 2.7.7.10
| CAS_number = 9016-11-9
| IUBMB_EC_number = 2/7/7/10
| GO_code = 0017103
| image =
| width =
| caption =
}}

In enzymology, an UTP—hexose-1-phosphate uridylyltransferase ({{EC number|2.7.7.10}}) is an enzyme that catalyzes the chemical reaction

UTP + alpha-D-galactose 1-phosphate diphosphate + UDP-galactose

Thus, the two substrates of this enzyme are UTP and alpha-D-galactose 1-phosphate, whereas its two products are diphosphate and UDP-galactose.

Enzyme family

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is UTP:alpha-D-hexose-1-phosphate uridylyltransferase. Other names in common use include galactose-1-phosphate uridylyltransferase, galactose 1-phosphate uridylyltransferase, alpha-D-galactose 1-phosphate uridylyltransferase, galactose 1-phosphate uridyltransferase, UDPgalactose pyrophosphorylase, uridine diphosphate galactose pyrophosphorylase, and uridine diphosphogalactose pyrophosphorylase. This enzyme participates in galactose metabolism and nucleotide sugars metabolism.

Structural studies

{{As of|2007|alt=As of late 2007}}, 3 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1GUP}}, {{PDB link|1GUQ}}, and {{PDB link|1HXP}}.

References

{{cite journal | author = ISSELBACHER KJ | year = 1958 | title = A mammalian uridinediphosphate galactose pyrophosphorylase | journal = J. Biol. Chem. | volume = 232 | pages = 429–44 | pmid = 13549431 | issue = 1 }}
{{cite journal | author = KALCKAR HM | year = 1953 | title = The role of phosphoglycosyl compounds in the biosynthesis of nucleosides and nucleotides | journal = Biochim. Biophys. Acta | volume = 12 | pages = 250–64 | pmid = 13115434 | doi = 10.1016/0006-3002(53)90144-9 | issue = 1–2 }}
{{cite journal | vauthors = Lee L, Kimura A, Tochikura T | location = Tokyo | title = Purification and properties of UDP-glucose (UDP-galactose) pyrophosphorylase from Bifidobacterium bifidum | journal = J. Biochem. | volume = 86| pages = 923–8 | pmid = 500588 | issue = 4 | date=October 1979}}
{{cite journal | vauthors = Lobelle-Rich PA, Reeves RE | year = 1983 | title = Separation and characterization of two UTP-utilizing hexose phosphate uridylyltransferases from Entamoeba histolytica | journal = Mol. Biochem. Parasitol. | volume = 7 | pages = 173–82 | pmid = 6304512 | doi = 10.1016/0166-6851(83)90043-9 | issue = 2 }}

{{Kinases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{DEFAULTSORT:UTP-hexose-1-phosphate uridylyltransferase}}{{2.7-enzyme-stub}}

2 : EC 2.7.7|Enzymes of known structure

随便看

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。