释义 |
- References
- Further reading
{{Underlinked|date=May 2014}}{{Infobox_gene}}UV radiation resistance-associated gene protein is a protein that in humans is encoded by the UVRAG gene.[1][2]{{PBB_Summary | section_title = | summary_text = This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.[2] }}References1. ^{{cite journal |vauthors=Perelman B, Dafni N, Naiman T, Eli D, Yaakov M, Feng TL, Sinha S, Weber G, Khodaei S, Sancar A, Dotan I, Canaani D | title = Molecular cloning of a novel human gene encoding a 63-kDa protein and its sublocalization within the 11q13 locus | journal = Genomics | volume = 41 | issue = 3 | pages = 397–405 |date=Jul 1997 | pmid = 9169138 | pmc = | doi = 10.1006/geno.1997.4623 }} 2. ^1 {{cite web | title = Entrez Gene: UVRAG UV radiation resistance associated gene| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7405| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal | author=Liang C |title=UVRAG: a new player in autophagy and tumor cell growth |journal=Autophagy |volume=3 |issue= 1 |pages= 69–71 |year= 2007 |pmid= 17106237 |doi= 10.4161/auto.3437|name-list-format=vanc| author2=Feng P | author3=Ku B | display-authors=3 | last4=Oh | first4=BH | last5=Jung | first5=JU }}
- {{cite journal | author=Teitz T |title=Isolation by polymerase chain reaction of a cDNA whose product partially complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells |journal=Gene |volume=87 |issue= 2 |pages= 295–298 |year= 1990 |pmid= 2332174 |doi=10.1016/0378-1119(90)90316-J |name-list-format=vanc| author2=Penner M | author3=Eli D | display-authors=3 | last4=Stark | first4=Merav | last5=Bakhanashvili | first5=Mary | last6=Naiman | first6=Tova | last7=Canaani | first7=Dan }}
- {{cite journal |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–174 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
- {{cite journal | author=Suzuki Y |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–156 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |name-list-format=vanc| author2=Yoshitomo-Nakagawa K | author3=Maruyama K | display-authors=3 | last4=Suyama | first4=A | last5=Sugano | first5=S }}
- {{cite journal | author=Bekri S |title=Detailed map of a region commonly amplified at 11q13→q14 in human breast carcinoma |journal=Cytogenet. Cell Genet. |volume=79 |issue= 1–2 |pages= 125–131 |year= 1998 |pmid= 9533029 |doi=10.1159/000134699 |name-list-format=vanc| author2=Adélaïde J | author3=Merscher S | display-authors=3 | last4=Grosgeorge | first4=J. | last5=Caroli-Bosc | first5=F. | last6=Perucca-Lostanlen | first6=D.P. | last7=Kelley | first7=P.M. | last8=pÉBusque | first8=M.-J. | last9=Theillet | first9=C. }}
- {{cite journal | author=Iida A |title=Identification of a gene disrupted by inv(11)(q13.5;q25) in a patient with left-right axis malformation |journal=Hum. Genet. |volume=106 |issue= 3 |pages= 277–287 |year= 2000 |pmid= 10798355 |doi=10.1007/s004390051038 |name-list-format=vanc| author2=Emi M | author3=Matsuoka R | display-authors=3 | last4=Hiratsuka | first4=E. | last5=Okui | first5=K. | last6=Ohashi | first6=H. | last7=Inazawa | first7=J. | last8=Fukushima | first8=Y. | last9=Imai | first9=T. }}
- {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }}
- {{cite journal | author=Goi T |title=Ascending colon cancer with hepatic metastasis and cholecystolithiasis in a patient with situs inversus totalis without any expression of UVRAG mRNA: report of a case |journal=Surg. Today |volume=33 |issue= 9 |pages= 702–706 |year= 2004 |pmid= 12928850 |doi= 10.1007/s00595-002-2567-y |name-list-format=vanc| author2=Kawasaki M | author3=Yamazaki T | display-authors=3 | last4=Koneri | first4=Kenji | last5=Katayama | first5=Kanji | last6=Hirose | first6=Kazuo | last7=Yamaguchi | first7=Akio }}
- {{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–45 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki }}
- {{cite journal | author=Ionov Y |title=Manipulation of nonsense mediated decay identifies gene mutations in colon cancer Cells with microsatellite instability |journal=Oncogene |volume=23 |issue= 3 |pages= 639–645 |year= 2004 |pmid= 14737099 |doi= 10.1038/sj.onc.1207178 |name-list-format=vanc| author2=Nowak N | author3=Perucho M | display-authors=3 | last4=Markowitz | first4=Sanford | last5=Cowell | first5=John K }}
- {{cite journal | author=Kimura K |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |name-list-format=vanc| author2=Wakamatsu A | author3=Suzuki Y | display-authors=3 | last4=Ota | first4=T | last5=Nishikawa | first5=T | last6=Yamashita | first6=R | last7=Yamamoto | first7=J | last8=Sekine | first8=M | last9=Tsuritani | first9=K }}
- {{cite journal | author=Liang C |title=Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG |journal=Nat. Cell Biol. |volume=8 |issue= 7 |pages= 688–698 |year= 2006 |pmid= 16799551 |doi= 10.1038/ncb1426 |name-list-format=vanc| author2=Feng P | author3=Ku B | display-authors=3 | last4=Dotan | first4=Iris | last5=Canaani | first5=Dan | last6=Oh | first6=Byung-Ha | last7=Jung | first7=Jae U. }}
{{refend}}{{gene-11-stub}} |