“Vascular endothelial growth factor B”的意思、由来-开放百科全书

Vascular endothelial growth factor B also known as VEGF-B is a protein that, in humans, is encoded by the VEGF-B gene.^[1] VEGF-B is a growth factor that belongs to the vascular endothelial growth factor family, of which VEGF-A is the best-known member.

Function

In contrast to VEGF-A, VEGF-B plays a less pronounced role in the vascular system: Whereas VEGF-A is important for the formation of blood vessels, such as during development or in pathological conditions, VEGF-B seems to play a role only in the maintenance of newly formed blood vessels during pathological conditions.^[2]

VEGF-B plays also an important role on several types of neurons. It is important for the protection of neurons in the retina^[3] and the cerebral cortex during stroke ^[4] and of motoneurons during motor neuron diseases such as amyotrophic lateral sclerosis.^[5]

VEGF-B has also been found to control endothelial uptake and transport of fatty acids in heart and skeletal muscle.^[7]^[8]

Interactions

Vascular endothelial growth factor B has been shown to interact with FLT1.^[9]^[10]

References

1. ^{{cite web | title = Entrez Gene: VEGFB vascular endothelial growth factor B| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7423| accessdate = }}
2. ^{{cite journal |vauthors=Zhang F, Tang Z, Hou X, Lennartsson J, Li Y, Koch AW, Scotney P, Lee C, Arjunan P, Dong L, Kumar A, Rissanen TT, Wang B, Nagai N, Fons P, Fariss R, Zhang Y, Wawrousek E, Tansey G, Raber J, Fong GH, Ding H, Greenberg DA, Becker KG, Herbert JM, Nash A, Yla-Herttuala S, Cao Y, Watts RJ, Li X | title = VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 106 | issue = 15 | pages = 6152–7 |date=April 2009 | pmid = 19369214 | doi = 10.1073/pnas.0813061106 | url = | issn = | pmc = 2669337 }}
3. ^{{cite journal |vauthors=Li Y, Zhang F, Nagai N, Tang Z, Zhang S, Scotney P, Lennartsson J, Zhu C, Qu Y, Fang C, Hua J, Matsuo O, Fong GH, Ding H, Cao Y, Becker KG, Nash A, Heldin CH, Li X | title = VEGF-B inhibits apoptosis via VEGFR-1-mediated suppression of the expression of BH3-only protein genes in mice and rats | journal = J. Clin. Invest. | volume = 118 | issue = 3 | pages = 913–23 |date=March 2008 | pmid = 18259607 | pmc = 2230661 | doi = 10.1172/JCI33673 | url = | issn = }}
4. ^{{cite journal |vauthors=Sun Y, Jin K, Childs JT, Xie L, Mao XO, Greenberg DA | title = Increased severity of cerebral ischemic injury in vascular endothelial growth factor-B-deficient mice | journal = J. Cereb. Blood Flow Metab. | volume = 24 | issue = 10 | pages = 1146–52 |date=October 2004 | pmid = 15529014 | doi = 10.1097/01.wcb.0000134477.38980.38| url = | issn = }}
5. ^{{cite journal |vauthors=Poesen K, Lambrechts D, Van Damme P, Dhondt J, Bender F, Frank N, Bogaert E, Claes B, Heylen L, Verheyen A, Raes K, Tjwa M, Eriksson U, Shibuya M, Nuydens R, Van Den Bosch L, Meert T, D'Hooge R, Sendtner M, Robberecht W, Carmeliet P | title = Novel role for vascular endothelial growth factor (VEGF) receptor-1 and its ligand VEGF-B in motor neuron degeneration | journal = J. Neurosci. | volume = 28 | issue = 42 | pages = 10451–9 |date=October 2008 | pmid = 18923022 | doi = 10.1523/JNEUROSCI.1092-08.2008 | url = | issn = }}
6. ^{{cite journal |vauthors=Yamazaki Y, Morita T | title = Molecular and functional diversity of vascular endothelial growth factors | journal = Mol. Divers. | volume = 10 | issue = 4 | pages = 515–27 |date=November 2006 | pmid = 16972015 | doi = 10.1007/s11030-006-9027-3 | url = | issn = }}
7. ^{{cite journal | author = Muoio DM | title = Metabolism and vascular fatty acid transport | journal = N. Engl. J. Med. | volume = 363 | issue = 3 | pages = 291–3 |date=July 2010 | pmid = 20647206 | doi = 10.1056/NEJMcibr1005397 }}
8. ^{{cite journal |vauthors=Hagberg CE, Mehlem A, Falkevall A, Muhl L, Fam BC, Ortsäter H, Scotney P, Nyqvist D, Samén E, Lu L, Stone-Elander S, Proietto J, Andrikopoulos S, Sjöholm A, Nash A, Eriksson U | title = Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes | journal = Nature | volume = 490 | issue = 7420 | pages = 426–30 |date=October 2012 | pmid = 23023133 | doi = 10.1038/nature11464 }}
9. ^{{cite journal |vauthors=Olofsson B, Korpelainen E, Pepper MS, Mandriota SJ, Aase K, Kumar V, Gunji Y, Jeltsch MM, Shibuya M, Alitalo K, Eriksson U | title = Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | issue = 20 | pages = 11709–14 |date=September 1998 | pmid = 9751730 | pmc = 21705 | doi = 10.1073/pnas.95.20.11709 }}
10. ^{{cite journal |vauthors=Makinen T, Olofsson B, Karpanen T, Hellman U, Soker S, Klagsbrun M, Eriksson U, Alitalo K | title = Differential binding of vascular endothelial growth factor B splice and proteolytic isoforms to neuropilin-1 | journal = J. Biol. Chem. | volume = 274 | issue = 30 | pages = 21217–22 |date=July 1999 | pmid = 10409677 | doi = 10.1074/jbc.274.30.21217 }}

Function

Interactions

References

Further reading