| 释义 |
- References
- Further reading
{{Infobox_gene}}Synaptic vesicle membrane protein VAT-1 homolog is a protein that in humans is encoded by the VAT1 gene.[1][2][3]{{PBB_Summary
| section_title =
| summary_text = Synaptic vesicles are responsible for regulating the storage and release of neurotransmitters in the nerve terminal. The protein encoded by this gene is an abundant integral membrane protein of cholinergic synaptic vesicles and is thought to be involved in vesicular transport. It belongs to the quinone oxidoreductase subfamily of zinc-containing alcohol dehydrogenase proteins.[3]In melanocytic cells VAT1 gene expression may be regulated by MITF.[4]
}}References1. ^{{cite journal |vauthors=Friedman LS, Ostermeyer EA, Lynch ED, Welcsh P, Szabo CI, Meza JE, Anderson LA, Dowd P, Lee MK, Rowell SE, etal | title = 22 genes from chromosome 17q21: cloning, sequencing, and characterization of mutations in breast cancer families and tumors | journal = Genomics | volume = 25 | issue = 1 | pages = 256–63 |date=Jul 1995 | pmid = 7774926 | pmc = | doi =10.1016/0888-7543(95)80133-7 }}
2. ^{{cite journal | vauthors = Smith TM, Lee MK, Szabo CI, Jerome N, McEuen M, Taylor M, Hood L, King MC | title = Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1 | journal = Genome Res | volume = 6 | issue = 11 | pages = 1029–49 |date=Feb 1997 | pmid = 8938427 | pmc = | doi =10.1101/gr.6.11.1029 }}
3. ^1 {{cite web | title = Entrez Gene: VAT1 vesicle amine transport protein 1 homolog (T. californica)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10493| accessdate = }}
4. ^{{cite journal |vauthors=Hoek KS, Schlegel NC, Eichhoff OM, etal | title = Novel MITF targets identified using a two-step DNA microarray strategy | journal = Pigment Cell Melanoma Res. | volume = 21 | issue = 6 | pages = 665–76 | year = 2008 | pmid = 19067971 | doi = 10.1111/j.1755-148X.2008.00505.x }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Miki Y, Swensen J, Shattuck-Eidens D, etal |title=A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. |journal=Science |volume=266 |issue= 5182 |pages= 66–71 |year= 1994 |pmid= 7545954 |doi=10.1126/science.7545954 }}
- {{cite journal |vauthors=Harshman K, Bell R, Rosenthal J, etal |title=Comparison of the positional cloning methods used to isolate the BRCA1 gene. |journal=Hum. Mol. Genet. |volume=4 |issue= 8 |pages= 1259–66 |year= 1995 |pmid= 7581362 |doi=10.1093/hmg/4.8.1259 }}
- {{cite journal |vauthors=Friedman LS, Ostermeyer EA, Lynch ED, etal |title=The search for BRCA1. |journal=Cancer Res. |volume=54 |issue= 24 |pages= 6374–82 |year= 1995 |pmid= 7987831 |doi= }}
- {{cite journal |vauthors=Matoba R, Okubo K, Hori N, etal |title=The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression. |journal=Gene |volume=146 |issue= 2 |pages= 199–207 |year= 1994 |pmid= 8076819 |doi=10.1016/0378-1119(94)90293-3 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
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