| 词条 | VCX |
| 释义 |
| section_title = | summary_text = This gene belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. The X-linked members are clustered on chromosome Xp22 and Y-linked members are two identical copies of the gene within a palindromic region on Yq11. The family members share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. The VCX gene cluster is polymorphic in terms of copy number; different individuals may have a different number of VCX genes. VCX/Y genes encode small and highly charged proteins of unknown function. The presence of a putative bipartite nuclear localization signal suggests that VCX/Y members are nuclear proteins. This gene contains 10 repeats of the 30-bp unit.[3] }} References1. ^{{cite journal |vauthors=Lahn BT, Page DC | title = A human sex-chromosomal gene family expressed in male germ cells and encoding variably charged proteins | journal = Hum Mol Genet | volume = 9 | issue = 2 | pages = 311–9 |date=Feb 2000 | pmid = 10607842 | pmc = | doi =10.1093/hmg/9.2.311 }} 2. ^{{cite journal |vauthors=Fukami M, Kirsch S, Schiller S, Richter A, Benes V, Franco B, Muroya K, Rao E, Merker S, Niesler B, Ballabio A, Ansorge W, Ogata T, Rappold GA | title = A Member of a Gene Family on Xp22.3, VCX-A, Is Deleted in Patients with X-Linked Nonspecific Mental Retardation | journal = Am J Hum Genet | volume = 67 | issue = 3 | pages = 563–73 |date=Sep 2000 | pmid = 10903929 | pmc = 1287516 | doi = 10.1086/303047 }} 3. ^1 {{cite web | title = Entrez Gene: VCX variable charge, X-linked| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26609| accessdate = }} Further reading{{refbegin | 2}}
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