Below is the history of the office holders.[1][2] The list is complete.
| Picture | Name | Took Office | Left Office | President |
|---|
| José Joaquín de Olmedo | 1830 | 1831 | Juan José Flores |
| José Modesto Larrea | 1831 | 1835 | Juan José Flores |
| Juan Bernardo León | 1835 | 1839 | Vicente Rocafuerte |
| Francisco Aguirre | 1839 | 1843 | Juan José Flores |
| Francisco Marcos | 1843 | 1845 | Juan José Flores |
| Pablo Merino | 1845 | 1847 | Vicente Ramón Roca |
| Manuel de Ascásubi | 1847 | 1851 | Vicente Ramón Roca |
| Position abolished | 1851 | 1852 | |
| Pacifico Chiriboga | 1852 | 1854 | José María Urbina |
| Manuel Bustamante | 1854 | 1856 | José María Urbina |
| Marcos Espinel | 1856 | 1858 | José María Urbina
Francisco Robles |
| Jerónimo Carrión | 1858 | 1860 | Francisco Robles |
| Mariano Cueva | 1861 | 1863 | Gabriel García Moreno |
| Antonio Borrero | 1863 | 1864 | Gabriel García Moreno |
| Rafael Carvajal | 1864 | 1865 | Gabriel García Moreno |
| Pedro José de Arteta | 1865 | 1867 | Jerónimo Carrión |
| Position vacant | 1867 | 1868 | |
| Pedro José de Arteta | 1868 | 1869 | Juan Javier Espinosa |
| Francisco Javier León | 1869 | 1875 | Gabriel García Moreno |
| Position vacant | 1875 | 1883 | |
| Rafael Pérez Pareja | 1883 | 1884 | José Plácido Caamaño |
| Agustín Guerrero Lizarzaburu | 1884 | 1886 | José Plácido Caamaño |
| Pedro José Cevallos | 1886 | 1890 | José Plácido Caamaño
Antonio Flores Jijón |
| Pablo Herrera | 1890 | 1894 | Antonio Flores Jijón
Luis Cordero Crespo |
| Vicente Lucio Salazar | 1894 | 1895 | Luis Cordero Crespo |
| Position vacant | 1895 | 1897 | |
| Manuel Benigno Cueva | 1897 | 1899 | Eloy Alfaro |
| Carlos Freire Zaldumbide | 1899 | 1903 | Eloy Alfaro
Leonidas Plaza |
| Alfredo Baquerizo | 1903 | 1906 | Leonidas Plaza
Lizardo García |
| Position abolished | 1906 | 1946 | |
| Mariano Suárez Veintimilla | 1946 | 1947 | José María Velasco Ibarra |
| José Rafael Bustamante | 1947 | 1948 | Carlos Julio Arosemena Tola |
| Manuel Sotomayor | 1948 | 1949 | Galo Plaza Lasso |
| Abel Gilbert | 1949 | 1952 | Galo Plaza Lasso |
| Alfredo Chiriboga | 1952 | 1956 | José María Velasco Ibarra |
| Francisco Illingworth | 1956 | 1960 | Camilo Ponce Enríquez |
| C. J. Arosemena Monroy | 1960 | 1961 | José María Velasco Ibarra |
| Reinaldo Varea | 1961 | 1963 | Carlos Julio Arosemena Monroy |
| Position vacant | 1963 | 1968 | |
| Jorge Zavala | 1968 | 1972 | José María Velasco Ibarra |
| Position vacant | 1972 | 1979 | |
| Osvaldo Hurtado | 1979 | 1981 | Jaime Roldós Aguilera |
| León Roldós Aguilera | 1981 | 1984 | Osvaldo Hurtado |
| Blasco Peñaherrera | 1984 | 1988 | León Febres Cordero |
| Luis Parodi | 1988 | 1992 | Rodrigo Borja |
| Alberto Dahik | 1992 | 1995 | Sixto Durán Ballén |
| Eduardo Peña | 1995 | 1996 | Sixto Durán Ballén |
| Rosalía Arteaga | 1996 | 1998 | Abdalá Bucaram
Fabián Alarcón |
| Pedro Aguayo Cubillo | 1998 | 1998 | Fabián Alarcón |
| Gustavo Noboa | 1998 | 2000 | Jamil Mahuad |
| Pedro Pinto Rubianes | 2000 | 2003 | Gustavo Noboa |
| Alfredo Palacio | 2003 | 2005 | Lucio Gutierrez |
| Alejandro Serrano | 2005 | 2007 | Alfredo Palacio |
| Lenín Moreno | 15 January 2007 | 24 May 2013 | Rafael Correa |
| Jorge Glas | 24 May 2013 | {{small|Powers and duties suspended on 3 August 2017}}
6 January 2018 | Rafael Correa
Lenín Moreno |
| María Alejandra Vicuña | 4 October 2017 | {{small>(Acting [for Jorge Glas to 2 January 2018])}} | Lenín Moreno |
| 6 January 2018 | Powers and duties suspended on 3 December 2018}}
4 December 2018 |
| Otto Sonnenholzner | 11 December 2018 | Incumbent | Lenín Moreno |
1. ^[https://web.archive.org/web/20080115011534/http://www.vicepresidencia.gov.ec/index.php?option=com_content&task=category§ionid=4&id=15&Itemid=30 History of Vicepresidency]
2. ^{{cite web|url=http://www.vicepresidencia.gob.ec/wp-content/uploads/downloads/2013/10/VICEPRESIDENTES-EN-LA-HISTORIA-2013.pdf|format=PDF|title=Vicepresidentes en la historia|website=www.vicepresidencia.gob.ec|accessdate=25 November 2017}}