| 词条 | Vinculin family |
| 释义 |
| Symbol = Vinculin | Name = Vinculin family | image = | width = | caption = | Pfam= PF01044 | InterPro= IPR006077 | SMART= | Prosite = PDOC00568 | SCOP = 1dow | TCDB = | OPM family= | OPM protein= | PDB={{PDB3|1tr2}}B:3-1133 {{PDB3|1syq}}A:3-257 {{PDB3|1rke}}A:3-257{{PDB3|1rkc}}A:3-257 {{PDB3|1qkr}}B:973-1134 {{PDB3|1u6h}}A:3-258{{PDB3|1st6}}A:3-1134 {{PDB3|1zvz}}A:3-258 {{PDB3|1zw2}}A:3-258{{PDB3|1zw3}}A:3-258 {{PDB3|1t01}}A:3-253 {{PDB3|1xwj}}A:3-258{{PDB3|1dov}}A:82-262 {{PDB3|1dow}}A:57-261 {{PDB3|1h6g}}B:377-632{{PDB3|1l7c}}C:385-651 }} Vinculin is a eukaryotic protein that seems to be involved in the attachment of the actin-based microfilaments to the plasma membrane. Vinculin is located at the cytoplasmic side of focal contacts or adhesion plaques.[1] In addition to actin, vinculin interacts with other structural proteins such as talin and alpha-actinins. Vinculin is a large protein of 116 kDa (about a 1000 residues). Structurally the protein consists of an acidic N-terminal domain of about 90 kDa separated from a basic C-terminal domain of about 25 kDa by a proline-rich region of about 50 residues. The central part of the N-terminal domain consists of a variable number (3 in vertebrates, 2 in Caenorhabditis elegans) of repeats of a 110 amino acids domain. Alpha-catenins are evolutionary related to vinculin.[2] Catenins are proteins that associate with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Three different types of catenins seem to exist: alpha, beta, and gamma. Alpha-catenins are proteins of about 100 kDa which are evolutionary related to vinculin. In terms of their structure the most significant differences are the absence, in alpha-catenin, of the repeated domain and of the proline-rich segment. Subfamilies
Human proteins containing this domainCTNNA1; CTNNA2; CTNNA3; CTNNAL1; VCL; References1. ^{{cite journal |author=Otto JJ |title=Vinculin |journal=Cell Motil. Cytoskeleton |volume=16 |issue=1 |pages=1–6 |year=1990 |pmid=2112986 |doi=10.1002/cm.970160102}} {{InterPro content|IPR006077}}2. ^{{cite journal |vauthors=Lottspeich F, Eckerskorn C, Herrenknecht K, Ozawa M, Lenter M, Kemler R |title=The uvomorulin-anchorage protein alpha catenin is a vinculin homologue |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue=20 |pages=9156–9160 |year=1991 |pmid=1924379 |doi=10.1073/pnas.88.20.9156 |pmc=52671}} 3 : Protein domains|Protein families|Membrane proteins |
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