“Vinorine synthase”的意思、由来-开放百科全书

词条

Vinorine synthase

释义

Structural studies
References

{{enzyme
| Name = vinorine synthase
| EC_number = 2.3.1.160
| CAS_number = 88844-97-7
| IUBMB_EC_number = 2/3/1/160
| GO_code = 0050636
| image =
| width =
| caption =
}}

In enzymology, a vinorine synthase ({{EC number|2.3.1.160}}) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + 16-epivellosimine CoA + vinorine

Thus, the two substrates of this enzyme are acetyl-CoA and 16-epivellosimine, whereas its two products are CoA and vinorine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:16-epivellosimine O-acetyltransferase (cyclizing). This enzyme participates in indole and ipecac alkaloid biosynthesis.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code {{PDB link|2BGH}}.

References

{{cite journal | vauthors = Pfitzner A, Polz L, Stockligt J | date = 1986 | title = Properties of vinorine synthase the Rauwolfia enzyme involved in the formation of the ajmaline skeleton | journal = Z. Naturforsch. C: Biosci. | volume = 41 | pages = 103–114 }}
{{cite journal | vauthors = Bayer A, Ma X, Stockigt J | date = 2004 | title = Acetyltransfer in natural product biosynthesis--functional cloning and molecular analysis of vinorine synthase | journal = Bioorg. Med. Chem. | volume = 12 | pages = 2787–95 | pmid = 15110860 | doi = 10.1016/j.bmc.2004.02.029 | issue = 10 }}
{{cite journal | author = Stockigt J | date = 2004 | title = Vinorine synthase from Rauvolfia: the first example of crystallization and preliminary X-ray diffraction analysis of an enzyme of the BAHD superfamily | journal = Biochim. Biophys. Acta | volume = 1701 | pages = 129–32 | pmid = 15450182 | last2 = Koepke | first2 = J | last3 = Bayer | first3 = A | last4 = Linhard | first4 = V | last5 = Fritzsch | first5 = G | last6 = Zhang | first6 = B | last7 = Michel | first7 = H | last8 = Stöckigt | first8 = J | issue = 1–2 | doi = 10.1016/j.bbapap.2004.06.011 }}
{{cite journal | vauthors = Ma X, Koepke J, Panjikar S, Fritzsch G, Stockigt J | date = 2005 | title = Crystal structure of vinorine synthase, the first representative of the BAHD superfamily | journal = J. Biol. Chem. | volume = 280 | pages = 13576–83 | pmid = 15665331 | doi = 10.1074/jbc.M414508200 | issue = 14 }}

2 : EC 2.3.1|Enzymes of known structure

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