| 词条 | VUF-8430 |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 470627514 | ImageFile = VUF-8430_structure.png | ImageFile_Ref = {{chemboximage|correct|??}} | ImageName = Skeletal formula of VUF-8430 | PIN = 2-[(Aminoiminomethyl)amino]ethyl carbamimidothioic acid ester{{Citation needed|date = October 2011}} |Section1={{Chembox Identifiers | IUPHAR_ligand = 1274 | Abbreviations = VUF-8430 | CASNo_Ref = {{cascite|changed|??}} | CASNo = 98021-17-1 | PubChem = 3063228 | ChemSpiderID = 2323820 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChEMBL = 1196470 | ChEMBL_Ref = {{ebicite|changed|EBI}} | SMILES = NC(=N)NCCSC(N)=N | StdInChI = 1S/C4H11N5S/c5-3(6)9-1-2-10-4(7)8/h1-2H2,(H3,7,8)(H4,5,6,9) | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = GSYGTVNTZHFQQH-UHFFFAOYSA-N | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} }} |Section2={{Chembox Properties | C=4 | H=11 | N=5 | S=1 | LogP = -1.367 }} }}VUF-8430 is a histamine agonist[1] selective for the H4 subtype.[2] References1. ^{{cite journal |vauthors=Smith FM, Haskelberg H, Tracey DJ, Moalem-Taylor G |title=Role of histamine H3 and H4 receptors in mechanical hyperalgesia following peripheral nerve injury |journal=Neuroimmunomodulation |volume=14 |issue=6 |pages=317–25 |year=2007 |pmid=18401194 |doi=10.1159/000125048 |url=http://content.karger.com/produktedb/produkte.asp?typ=fulltext&file=000125048}} {{Histaminergics}}{{Amine-stub}}{{Pharma-stub}}2. ^{{cite journal | last1 = Lim | first1 = HD | last2 = Smits | first2 = RA | last3 = Bakker | first3 = RA | last4 = Van Dam | first4 = CM | last5 = De Esch | first5 = IJ | last6 = Leurs | first6 = R | title = Discovery of S-(2-guanidylethyl)-isothiourea (VUF 8430) as a potent nonimidazole histamine H4 receptor agonist. | journal = Journal of Medicinal Chemistry | volume = 49 | issue = 23 | pages = 6650–1 | year = 2006 | pmid = 17154494 | doi = 10.1021/jm060880d }} 3 : Histamine agonists|Guanidines|Thioureas |
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