| 词条 | Anthony Pawson |
| 释义 |
| birth_name = Anthony James Pawson | image = File:Anthony pawson.jpg | birth_date = {{Birth date|df=yes|1952|10|18}} | birth_place = Maidstone, England | death_date={{Death date and age|df=yes|2013|8|7|1952|10|18}} | death_place=Toronto, Ontario | nationality = British-Canadian | field = Genetics, microbiology | work_institutions = University of Toronto Mount Sinai Hospital, Toronto Samuel Lunenfeld Research Institute | alma_mater = Clare College, Cambridge King's College London {{small|(PhD)}} | thesis_title = Studies on the Proteins and Nucleic Acids of RNA Tumour Viruses | thesis_url = http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.468464 | thesis_year = 1976 | doctoral_advisor = | doctoral_students = | known_for = Cellular signal transduction | influences = | influenced = | prizes = {{no wrap|Gairdner Foundation International Award {{small|(1994)}} Flavelle Medal {{small|(1998)}} Wolf Prize in Medicine {{small|(2005)}} Royal Medal {{small|(2005)}} Kyoto Prize {{small|(2008)}} Fellow of the Royal Society}} | footnotes = }}Anthony "Tony" James Pawson, {{Post-nominals|country=CAN|OC|OOnt|CH|FRS|FRSC}} (18 October 1952 – 7 August 2013),[1] was a British-born Canadian scientist whose research has revolutionised the understanding of signal transduction, the molecular mechanisms by which cells respond to external cues, and how they communicate with each other. He identified the phosphotyrosine-binding Src homology 2 (SH2 domain) as the prototypic non-catalytic interaction module. SH2 domains serve as a model for a large family of protein modules that act together to control many aspects of cellular signalling. Since the discovery of SH2 domains, hundreds of different modules have been identified in many proteins.[2][3][4][5][6][7][8][9][10] BiographyBorn in Maidstone, England,[1] the son of the sportsman and writer Tony Pawson, and botanist and high-school teacher Hilarie, he was the eldest of three children.[11] He was educated at Winchester College[12] and Clare College, Cambridge where he received an MA in biochemistry followed by a PhD from King's College London in 1976. From 1976 to 1980 he pursued postdoctoral work at the University of California, Berkeley. From 1981 to 1985, he was Assistant Professor in microbiology at the University of British Columbia. Pawson was a Distinguished Investigator and former Director of Research at the Samuel Lunenfeld Research Institute of Mount Sinai Hospital and Professor in the Department of Molecular Genetics at the University of Toronto both of which he joined in 1985. Pawson died on 7 August 2013 of unspecified causes at the age of 60.[13][14][15] Honours and awards
References1. ^1 {{Cite journal | last1 = Bernstein | first1 = Alan| authorlink1 = Alan Bernstein| last2 = Rossant | first2 = Janet| authorlink2 = Janet Rossant| doi = 10.1038/501168a | title = Anthony James Pawson (1952–2013) Biochemist whose vision of cell signalling transformed cancer research| journal = Nature | volume = 501 | issue = 7466 | pages = 168 | year = 2013 | pmid = 24025833| pmc = }} 2. ^{{Cite journal | last1 = Pawson | first1 = T. | last2 = Nash | first2 = P. | title = Assembly of Cell Regulatory Systems Through Protein Interaction Domains | doi = 10.1126/science.1083653 | journal = Science | volume = 300 | issue = 5618 | pages = 445–452 | year = 2003 | pmid = 12702867| pmc = | citeseerx = 10.1.1.321.3136 }} 3. ^{{Cite journal | last1 = Nash | first1 = P. | last2 = Tang | first2 = X. | last3 = Orlicky | first3 = S. | last4 = Chen | first4 = Q. | last5 = Gertler | first5 = F. B. | last6 = Mendenhall | first6 = M. D. | last7 = Sicheri | first7 = F. | last8 = Pawson | first8 = T. | last9 = Tyers | first9 = M. | doi = 10.1038/35107009 | title = Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication | journal = Nature | volume = 414 | issue = 6863 | pages = 514–521 | year = 2001 | pmid = 11734846| pmc = }} 4. ^{{Cite journal | last1 = Holland | first1 = S. J. | last2 = Gale | first2 = N. W. | last3 = Mbamalu | first3 = G. | last4 = Yancopoulos | first4 = G. D. | last5 = Henkemeyer | first5 = M. | last6 = Pawson | first6 = T. | doi = 10.1038/383722a0 | title = Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands | journal = Nature | volume = 383 | issue = 6602 | pages = 722–725 | year = 1996 | pmid = 8878483 | pmc = }} 5. ^{{Cite journal | last1 = Salcini | first1 = A. E. | last2 = McGlade | first2 = J. | last3 = Pelicci | first3 = G. | last4 = Nicoletti | first4 = I. | last5 = Pawson | first5 = T. | last6 = Pelicci | first6 = P. G. | title = Formation of Shc-Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins | journal = Oncogene | volume = 9 | issue = 10 | pages = 2827–2836 | year = 1994 | pmid = 8084588}} 6. ^{{Cite journal | last1 = Henkemeyer | first1 = M. | last2 = Marengere | first2 = L. E. | last3 = McGlade | first3 = J. | last4 = Olivier | first4 = J. P. | last5 = Conlon | first5 = R. A. | last6 = Holmyard | first6 = D. P. | last7 = Letwin | first7 = K. | last8 = Pawson | first8 = T. | title = Immunolocalization of the Nuk receptor tyrosine kinase suggests roles in segmental patterning of the brain and axonogenesis | journal = Oncogene | volume = 9 | issue = 4 | pages = 1001–1014 | year = 1994 | pmid = 8134103}} 7. ^{{Cite journal | doi = 10.1016/0896-6273(94)90223-2 | last1 = Stephens | first1 = R. M. | last2 = Loeb | first2 = D. M. | last3 = Copeland | first3 = T. D. | last4 = Pawson | first4 = T. | last5 = Greene | first5 = L. A. | last6 = Kaplan | first6 = D. R. | title = Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses | journal = Neuron | volume = 12 | issue = 3 | pages = 691–705 | year = 1994 | pmid = 8155326}} 8. ^{{Cite journal | last1 = Crowe | first1 = A. J. | last2 = McGlade | first2 = J. | last3 = Pawson | first3 = T. | last4 = Hayman | first4 = M. J. | title = Phosphorylation of the SHC proteins on tyrosine correlates with the transformation of fibroblasts and erythroblasts by the v-sea tyrosine kinase | journal = Oncogene | volume = 9 | issue = 2 | pages = 537–544 | year = 1994 | pmid = 8290264}} 9. ^{{Cite journal | last1 = Marengere | first1 = L. E. M. | last2 = Songyang | first2 = Z. | last3 = Gish | first3 = G. D. | last4 = Schaller | first4 = M. D. | last5 = Parsons | first5 = J. T. | last6 = Stern | first6 = M. J. | last7 = Cantley | first7 = L. C. | last8 = Pawson | first8 = T. | doi = 10.1038/369502a0 | title = SH2 domain specificity and activity modified by a single residue | journal = Nature | volume = 369 | issue = 6480 | pages = 502–505 | year = 1994 | pmid = 7515480 | pmc = }} 10. ^{{Cite journal | last1 = Moran | first1 = M. F. | title = Src Homology Region 2 Domains Direct Protein-Protein Interactions in Signal Transduction | doi = 10.1073/pnas.87.21.8622 | journal = Proceedings of the National Academy of Sciences | volume = 87 | issue = 21 | pages = 8622–8626 | year = 1990 | pmid = 2236073| pmc = 55009}} 11. ^{{cite news|author=Buck, Genna |date=14 August 2013 |url=https://www.theglobeandmail.com/life/health-and-fitness/health/anthony-pawson-helped-discover-how-cells-communicate-with-each-other/article13778193/ |title=Anthony Pawson helped discover how cells communicate with each other |newspaper=The Globe and Mail |accessdate=5 May 2014}} 12. ^{{cite web|last1=Kyriakis|first1=John M.|title=Retrospective Tony Pawson (1952–2013)|url=http://www.asbmb.org/asbmbtoday/asbmbtoday_article.aspx?id=48920|publisher=ASBMB Today|accessdate=16 January 2015}} 13. ^{{cite news|author= |url=https://www.thestar.com/life/health_wellness/2013/08/08/renowned_toronto_genetic_researcher_dr_tony_pawson_dies.html |title=Renowned Toronto genetic researcher Dr. Tony Pawson dies | Toronto Star |publisher=Thestar.com |date= 8 August 2013|accessdate=9 August 2013}} 14. ^{{cite news | title=Scientific community reels at the loss of the world-renowned Tony Pawson | url=http://www2.macleans.ca/2013/08/09/scientific-community-reels-at-the-loss-of-the-world-renowned-tony-pawson/ | work=Maclean's | date=9 August 2013 | accessdate=10 August 2013}} 15. ^{{cite news | author=Paul Wells| title=RIP Tony Pawson | url=http://www2.macleans.ca/2013/08/09/rip-tony-pawson/ | work=Maclean's | date=9 August 2013 | accessdate=10 August 2013}} External links
21 : 1952 births|2013 deaths|People educated at Winchester College|Alumni of Clare College, Cambridge|Alumni of King's College London|British biochemists|British expatriates in Canada|Canadian biochemists|Molecular biologists|Fellows of the Royal Society of Canada|Fellows of the Royal Society|Kyoto laureates in Basic Sciences|Members of the Order of Ontario|Members of the Order of the Companions of Honour|Winners of the Heineken Prize|Officers of the Order of Canada|University of British Columbia faculty|University of Toronto faculty|Wolf Prize in Medicine laureates|Royal Medal winners|Members of the United States National Academy of Sciences |
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