| 释义 |
- Function
- Interactions
- References
- Further reading
{{Infobox_gene}}WD repeat domain 57 (U5 snRNP specific), also known as WDR57, is a gene found in many organisms, including, but not limited to Homo sapiens, Gallus gallus, Pan troglodytes, Canus familiaris, Bos taurus, Mus musculus, and Rattus norvegicus.[1] Function This gene encodes a component of the U5 small nuclear ribonucleoprotein (snRNP) particle. The U5 snRNP is part of the spliceosome, a multiprotein complex that catalyzes the removal of introns from pre-messenger RNAs.[1] Interactions WDR57 has been shown to interact with PRPF8[2][3] and EFTUD2.[2][3] References 1. ^1 {{cite web | title = Entrez Gene: WDR57 WD repeat domain 57 (U5 snRNP specific)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9410| accessdate = }}
2. ^1 {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
3. ^1 {{cite journal | vauthors = Achsel T, Ahrens K, Brahms H, Teigelkamp S, Lührmann R | title = The human U5-220kD protein (hPrp8) forms a stable RNA-free complex with several U5-specific proteins, including an RNA unwindase, a homologue of ribosomal elongation factor EF-2, and a novel WD-40 protein | journal = Molecular and Cellular Biology | volume = 18 | issue = 11 | pages = 6756–66 | date = Nov 1998 | pmid = 9774689 | pmc = 109259 | doi=10.1128/mcb.18.11.6756}}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Turner IA, Norman CM, Churcher MJ, Newman AJ | title = Roles of the U5 snRNP in spliceosome dynamics and catalysis | journal = Biochemical Society Transactions | volume = 32 | issue = Pt 6 | pages = 928–31 | date = Dec 2004 | pmid = 15506927 | doi = 10.1042/BST0320928 }}
- {{cite journal | vauthors = Neubauer G, King A, Rappsilber J, Calvio C, Watson M, Ajuh P, Sleeman J, Lamond A, Mann M | title = Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex | journal = Nature Genetics | volume = 20 | issue = 1 | pages = 46–50 | date = Sep 1998 | pmid = 9731529 | doi = 10.1038/1700 }}
- {{cite journal | vauthors = Achsel T, Ahrens K, Brahms H, Teigelkamp S, Lührmann R | title = The human U5-220kD protein (hPrp8) forms a stable RNA-free complex with several U5-specific proteins, including an RNA unwindase, a homologue of ribosomal elongation factor EF-2, and a novel WD-40 protein | journal = Molecular and Cellular Biology | volume = 18 | issue = 11 | pages = 6756–66 | date = Nov 1998 | pmid = 9774689 | pmc = 109259 | doi = 10.1128/mcb.18.11.6756}}
- {{cite journal | vauthors = Makarov EM, Makarova OV, Achsel T, Lührmann R | title = The human homologue of the yeast splicing factor prp6p contains multiple TPR elements and is stably associated with the U5 snRNP via protein-protein interactions | journal = Journal of Molecular Biology | volume = 298 | issue = 4 | pages = 567–75 | date = May 2000 | pmid = 10788320 | doi = 10.1006/jmbi.2000.3685 }}
- {{cite journal | vauthors = Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ | title = Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis | journal = RNA | volume = 8 | issue = 4 | pages = 426–39 | date = Apr 2002 | pmid = 11991638 | pmc = 1370266 | doi = 10.1017/S1355838202021088 }}
- {{cite journal | vauthors = Jordanova A, Irobi J, Thomas FP, Van Dijck P, Meerschaert K, Dewil M, Dierick I, Jacobs A, De Vriendt E, Guergueltcheva V, Rao CV, Tournev I, Gondim FA, D'Hooghe M, Van Gerwen V, Callaerts P, Van Den Bosch L, Timmermans JP, Robberecht W, Gettemans J, Thevelein JM, De Jonghe P, Kremensky I, Timmerman V | title = Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy | journal = Nature Genetics | volume = 38 | issue = 2 | pages = 197–202 | date = Feb 2006 | pmid = 16429158 | doi = 10.1038/ng1727 }}
- {{cite journal | vauthors = Liu S, Rauhut R, Vornlocher HP, Lührmann R | title = The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP | journal = RNA | volume = 12 | issue = 7 | pages = 1418–30 | date = Jul 2006 | pmid = 16723661 | pmc = 1484429 | doi = 10.1261/rna.55406 }}
- {{cite journal | vauthors = Higa LA, Wu M, Ye T, Kobayashi R, Sun H, Zhang H | title = CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation | journal = Nature Cell Biology | volume = 8 | issue = 11 | pages = 1277–83 | date = Nov 2006 | pmid = 17041588 | doi = 10.1038/ncb1490 }}
- {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
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