Wettin is:

• House of Wettin, a German Royal House
• Wettin Castle, near Halle, Saxony-Anhalt, Germany, ancestral seat of the House of Wettin
• Asteroid 90709 Wettin, named in the castle and House's honour
• Wettin, Saxony-Anhalt, a town in Saxony-Anhalt, where Wettin Castle is located
• Wettinus Augiensis (d. 824)
• SMS Wettin, a German pre-dreadnought battleship

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• Sucrase-isomaltase deficiency