| 释义 |
- References
- Further reading
{{Infobox_gene}}Histone-lysine N-methyltransferase NSD3 is an enzyme that in humans is encoded by the WHSC1L1 gene.[1][2]{{PBB_Summary
| section_title =
| summary_text = This gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. The function of the protein has not been determined. Two alternatively spliced variants have been described.[2]
}}The WHSC1L1 gene is amplified in several cancers, including lung cancer and head and neck cancer, and may play a role in carcinogenesis.[3][4] References1. ^{{cite journal |vauthors=Stec I, Nagl SB, van Ommen GJ, den Dunnen JT | title = The PWWP domain: a potential protein-protein interaction domain in nuclear proteins influencing differentiation? | journal = FEBS Lett | volume = 473 | issue = 1 | pages = 1–5 |date=Jun 2000 | pmid = 10802047 | pmc = | doi =10.1016/S0014-5793(00)01449-6 }}
2. ^1 {{cite web | title = Entrez Gene: WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54904| accessdate = }}
3. ^{{cite journal|last1=Kang|first1=D|last2=Cho|first2=HS|last3=Toyokawa|first3=G|last4=Kogure|first4=M|last5=Yamane|first5=Y|last6=Iwai|first6=Y|last7=Hayami|first7=S|last8=Tsunoda|first8=T|last9=Field|first9=HI|last10=Matsuda|first10=K|last11=Neal|first11=DE|last12=Ponder|first12=BA|last13=Maehara|first13=Y|last14=Nakamura|first14=Y|last15=Hamamoto|first15=R|title=The histone methyltransferase Wolf-Hirschhorn syndrome candidate 1-like 1 (WHSC1L1) is involved in human carcinogenesis.|journal=Genes, Chromosomes & Cancer|date=Feb 2013|volume=52|issue=2|pages=126–39|pmid=23011637|doi=10.1002/gcc.22012}}
4. ^{{cite journal|last1=Chen|first1=Y|last2=McGee|first2=J|last3=Chen|first3=X|last4=Doman|first4=TN|last5=Gong|first5=X|last6=Zhang|first6=Y|last7=Hamm|first7=N|last8=Ma|first8=X|last9=Higgs|first9=RE|last10=Bhagwat|first10=SV|last11=Buchanan|first11=S|last12=Peng|first12=SB|last13=Staschke|first13=KA|last14=Yadav|first14=V|last15=Yue|first15=Y|last16=Kouros-Mehr|first16=Hosein|title=Identification of Druggable Cancer Driver Genes Amplified across TCGA Datasets.|journal=PLoS ONE|date=2014|volume=9|issue=5|pages=e98293|pmid=24874471|doi=10.1371/journal.pone.0098293|pmc=4038530}}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Angrand PO, Apiou F, Stewart AF, etal |title=NSD3, a new SET domain-containing gene, maps to 8p12 and is amplified in human breast cancer cell lines. |journal=Genomics |volume=74 |issue= 1 |pages= 79–88 |year= 2001 |pmid= 11374904 |doi= 10.1006/geno.2001.6524 }}
- {{cite journal |vauthors=Stec I, van Ommen GJ, den Dunnen JT |title=WHSC1L1, on human chromosome 8p11.2, closely resembles WHSC1 and maps to a duplicated region shared with 4p16.3. |journal=Genomics |volume=76 |issue= 1–3 |pages= 5–8 |year= 2001 |pmid= 11549311 |doi= 10.1006/geno.2001.6581 }}
- {{cite journal |vauthors=Rosati R, La Starza R, Veronese A, etal |title=NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t(8;11)(p11.2;p15) |journal=Blood |volume=99 |issue= 10 |pages= 3857–60 |year= 2002 |pmid= 11986249 |doi=10.1182/blood.V99.10.3857 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Tonon G, Wong KK, Maulik G, etal |title=High-resolution genomic profiles of human lung cancer |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 27 |pages= 9625–30 |year= 2005 |pmid= 15983384 |doi= 10.1073/pnas.0504126102 | pmc=1160520 }}
- {{cite journal |vauthors=Kim SM, Kee HJ, Eom GH, etal |title=Characterization of a novel WHSC1-associated SET domain protein with H3K4 and H3K27 methyltransferase activity |journal=Biochem. Biophys. Res. Commun. |volume=345 |issue= 1 |pages= 318–23 |year= 2006 |pmid= 16682010 |doi= 10.1016/j.bbrc.2006.04.095 }}
{{refend}}{{PDB Gallery|geneid=54904}}{{gene-8-stub}} |