| 词条 | William Canfield |
| 释义 |
BiographyCanfield obtained a B.S. in Chemistry from the University of Puget Sound followed by a Ph.D. in Biochemistry and Molecular Biology and an M.D. from the School of Medicine at the University of Washington. Canfield currently holds a faculty position in medical glycobiology at the University of Oklahoma Health Sciences Center.[3] John Crowley took over a position as a CEO in Novazyme after leaving Bristol-Myers Squibb in March 2000 and together with {{ill|Dr. Y. T. Chen|zh|陳垣崇}}[4] at Duke University pushed for expedited approval by the U.S. Food and Drug Administration (FDA) of a new drug compound, NZ-1001 under orphan drug designation for the treatment of Glycogen storage disease type II in October 2005. The FDA stated: “We have determined that Novazyme’s recombinant human highly phosphorylated acid alpha-glucosidase (rhHPGAA) qualifies for orphan designation for enzyme replacement therapy in patients with all subtypes of glycogen storage disease type II (Pompe's disease).” [5][6] Subsequent research at Genzyme on NZ-1001 along with three other potential compounds brought approval of the first enzyme replacement therapy for Pompe's disease - Alglucosidase alfa (Myozyme or Lumizyme, Genzyme Inc) in 2006.[7] Popular cultureWilliam Canfield's work with Pompe Disease was fictionalized and made the subject of a 2010 movie Extraordinary Measures in which he is called Dr. Robert Stonehill and played by Harrison Ford.[8] References1. ^http://staging.okcommerce.gov/test1/dmdocuments/2003_August_Folio_22080446.pdf Oklahoma State department of commerce - August 2003 report. Retrieved 2009-11-21. {{DEFAULTSORT:Canfield, William}}2. ^http://www.catalysthealthventures.com/?page=26&type=other Acquisition details 3. ^http://ouphysicians.com/body.cfm?id=3960 4. ^{{cite|url=http://www.genomics.sinica.edu.tw/index.php?option=com_content&view=article&id=96&Itemid=211&lang=en | last=Chen |first= Yuan-Tsong | title=Genomics Research Center, Academia Sinica}} 5. ^{{cite news | year=2000 | url=http://worldpompe.org/index.php/news/article/414/ | title=Novazyme Pharmaceuticals Receives Orphan Drug Designation for Pompe Disease Therapy | publisher=International Pompe Association| accessdate=2009-11-21}} 6. ^{{cite news | year=2009 | first=Grethe | last=Boe | url=http://harrisonfordonline.com/?p=1588 | title=Crowley: The Untold Story | publisher=International Pompe Association| accessdate=2009-11-21}} 7. ^http://www.genzyme.com/components/highlights/myozyme_development.pdf 8. ^{{cite web|title=Genzyme|url=http://www.genzyme.com/en/promos/pompe-movie-faq.aspx|accessdate=18 May 2015}} 6 : Year of birth missing (living people)|Living people|American medical researchers|University of Oklahoma people|University of Puget Sound alumni|University of Washington alumni |
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