“WIPF1”的意思、由来-开放百科全书

Function

This gene encodes a protein that plays an important role in the organization of the actin cytoskeleton. Overexpression of WIP in mammalian cells has been shown to increase actin polymerization.^[1] The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome, an X-linked recessive disorder. Impairment of the interaction between these two proteins may contribute to the disease. Two transcript variants encoding the same protein have been identified for this gene.^[2] In patients lacking the WIPF1 gene WASp protein levels are depleted and WAS symptoms present.^[3]

Interactions

WIPF1 has been shown to interact with Wiskott-Aldrich syndrome protein,^[1]^[4] Cortactin^[5], NCK1^[4], and ITSN1^[6]. While Wiskott-Aldrich syndrome protein is expressed only in haematopoetic cells, WIPF1 is expressed ubiquitously^[1]. Majority of the mutations causing Wiskott Aldrich Syndrome are located in the WH1 domain of WASp.^[7] These mutations affect WASp-WIPF1 binding.^[8] WIPF1 yeast homologue verprolin Vrp1 binds class 1 myosin and enhances class 1 myosin dependent actin nucleation.^[9]

WIPF1 has an N-terminal profilin binding domain, two actin binding WH2 domains, a central polyproline stretch, and a C-terminal WASP Binding Domain.

References

1. ^¹²³{{cite journal | vauthors = Ramesh N, Antón IM, Hartwig JH, Geha RS | title = WIP, a protein associated with wiskott-aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 26 | pages = 14671–6 | date = Dec 1997 | pmid = 9405671 | pmc = 25088 | doi = 10.1073/pnas.94.26.14671 }}
2. ^¹{{cite web | title = Entrez Gene: WIPF1 WAS/WASL interacting protein family, member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7456| accessdate = }}
3. ^{{cite journal | vauthors = Lanzi G, Moratto D, Vairo D, Masneri S, Delmonte O, Paganini T, Parolini S, Tabellini G, Mazza C, Savoldi G, Montin D, Martino S, Tovo P, Pessach IM, Massaad MJ, Ramesh N, Porta F, Plebani A, Notarangelo LD, Geha RS, Giliani S | title = A novel primary human immunodeficiency due to deficiency in the WASP-interacting protein WIP | journal = The Journal of Experimental Medicine | volume = 209 | issue = 1 | pages = 29–34 | date = January 2012 | pmid = 22231303 | pmc = 3260865 | doi = 10.1084/JEM.20110896 | hdl = 11379/487873 }}
4. ^¹{{cite journal | vauthors = Antón IM, Lu W, Mayer BJ, Ramesh N, Geha RS | title = The Wiskott-Aldrich syndrome protein-interacting protein (WIP) binds to the adaptor protein Nck | journal = The Journal of Biological Chemistry | volume = 273 | issue = 33 | pages = 20992–5 | date = Aug 1998 | pmid = 9694849 | doi = 10.1074/jbc.273.33.20992 }}
5. ^{{cite journal | vauthors = Kinley AW, Weed SA, Weaver AM, Karginov AV, Bissonette E, Cooper JA, Parsons JT | title = Cortactin interacts with WIP in regulating Arp2/3 activation and membrane protrusion | journal = Current Biology | volume = 13 | issue = 5 | pages = 384–93 | date = Mar 2003 | pmid = 12620186 | doi = 10.1016/S0960-9822(03)00107-6 }}
6. ^{{Cite journal|last=Gryaznova|first=Tetyana|last2=Kropyvko|first2=Sergii|last3=Burdyniuk|first3=Mariia|last4=Gubar|first4=Olga|last5=Kryklyva|first5=Valentyna|last6=Tsyba|first6=Liudmyla|last7=Rynditch|first7=Alla|date=July 2015|title=Intersectin adaptor proteins are associated with actin-regulating protein WIP in invadopodia|journal=Cellular Signalling|volume=27|issue=7|pages=1499–1508|doi=10.1016/j.cellsig.2015.03.006|issn=1873-3913|pmid=25797047}}
7. ^{{cite journal | vauthors = Rajmohan R, Raodah A, Wong MH, Thanabalu T | title = Characterization of Wiskott-Aldrich syndrome (WAS) mutants using Saccharomyces cerevisiae | journal = FEMS Yeast Research | volume = 9 | issue = 8 | pages = 1226–35 | date = Dec 2009 | doi = 10.1111/j.1567-1364.2009.00581.x | pmid = 19817875 }}
8. ^{{cite journal | vauthors = Rajmohan R, Meng L, Yu S, Thanabalu T | title = WASP suppresses the growth defect of Saccharomyces cerevisiae las17Delta strain in the presence of WIP | journal = Biochemical and Biophysical Research Communications | volume = 342 | issue = 2 | pages = 529–36 | date = Apr 2006 | doi = 10.1016/j.bbrc.2006.01.160 | pmid = 16488394 }}
9. ^{{Cite journal|last=Sirotkin|first=Vladimir|last2=Beltzner|first2=Christopher C.|last3=Marchand|first3=Jean-Baptiste|last4=Pollard|first4=Thomas D.|date=2005-08-15|title=Interactions of WASp, myosin-I, and verprolin with Arp2/3 complex during actin patch assembly in fission yeast|url=http://jcb.rupress.org/content/170/4/637|journal=The Journal of Cell Biology|language=en|volume=170|issue=4|pages=637–648|doi=10.1083/jcb.200502053|issn=0021-9525|pmid=16087707|pmc=2171502}}

Further reading

{{cite journal | vauthors = Ramesh N, Antón IM, Martínez-Quiles N, Geha RS | title = Waltzing with WASP | journal = Trends in Cell Biology | volume = 9 | issue = 1 | pages = 15–9 | date = Jan 1999 | pmid = 10087612 | doi = 10.1016/S0962-8924(98)01411-1 }}

{{cite journal | vauthors = Antón IM, Lu W, Mayer BJ, Ramesh N, Geha RS | title = The Wiskott-Aldrich syndrome protein-interacting protein (WIP) binds to the adaptor protein Nck | journal = The Journal of Biological Chemistry | volume = 273 | issue = 33 | pages = 20992–5 | date = Aug 1998 | pmid = 9694849 | doi = 10.1074/jbc.273.33.20992 }}

{{cite journal | vauthors = Stewart DM, Tian L, Nelson DL | title = Mutations that cause the Wiskott-Aldrich syndrome impair the interaction of Wiskott-Aldrich syndrome protein (WASP) with WASP interacting protein | journal = Journal of Immunology | volume = 162 | issue = 8 | pages = 5019–24 | date = Apr 1999 | pmid = 10202051 | doi = }}

{{cite journal | vauthors = Vaduva G, Martinez-Quiles N, Anton IM, Martin NC, Geha RS, Hopper AK, Ramesh N | title = The human WASP-interacting protein, WIP, activates the cell polarity pathway in yeast | journal = The Journal of Biological Chemistry | volume = 274 | issue = 24 | pages = 17103–8 | date = Jun 1999 | pmid = 10358064 | doi = 10.1074/jbc.274.24.17103 }}

{{cite journal | vauthors = Moreau V, Frischknecht F, Reckmann I, Vincentelli R, Rabut G, Stewart D, Way M | title = A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization | journal = Nature Cell Biology | volume = 2 | issue = 7 | pages = 441–8 | date = Jul 2000 | pmid = 10878810 | doi = 10.1038/35017080 }}

{{cite journal | vauthors = Vetterkind S, Miki H, Takenawa T, Klawitz I, Scheidtmann KH, Preuss U | title = The rat homologue of Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP) associates with actin filaments, recruits N-WASP from the nucleus, and mediates mobilization of actin from stress fibers in favor of filopodia formation | journal = The Journal of Biological Chemistry | volume = 277 | issue = 1 | pages = 87–95 | date = Jan 2002 | pmid = 11687573 | doi = 10.1074/jbc.M104555200 }}

{{cite journal | vauthors = Antón IM, de la Fuente MA, Sims TN, Freeman S, Ramesh N, Hartwig JH, Dustin ML, Geha RS | title = WIP deficiency reveals a differential role for WIP and the actin cytoskeleton in T and B cell activation | journal = Immunity | volume = 16 | issue = 2 | pages = 193–204 | date = Feb 2002 | pmid = 11869681 | doi = 10.1016/S1074-7613(02)00268-6 }}

{{cite journal | vauthors = Scott MP, Zappacosta F, Kim EY, Annan RS, Miller WT | title = Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 31 | pages = 28238–46 | date = Aug 2002 | pmid = 12029088 | doi = 10.1074/jbc.M202783200 }}

{{cite journal | vauthors = Benesch S, Lommel S, Steffen A, Stradal TE, Scaplehorn N, Way M, Wehland J, Rottner K | title = Phosphatidylinositol 4,5-biphosphate (PIP2)-induced vesicle movement depends on N-WASP and involves Nck, WIP, and Grb2 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 40 | pages = 37771–6 | date = Oct 2002 | pmid = 12147689 | doi = 10.1074/jbc.M204145200 }}

{{cite journal | vauthors = Zettl M, Way M | title = The WH1 and EVH1 domains of WASP and Ena/VASP family members bind distinct sequence motifs | journal = Current Biology | volume = 12 | issue = 18 | pages = 1617–22 | date = Sep 2002 | pmid = 12372256 | doi = 10.1016/S0960-9822(02)01112-0 }}

{{cite journal | vauthors = Volkman BF, Prehoda KE, Scott JA, Peterson FC, Lim WA | title = Structure of the N-WASP EVH1 domain-WIP complex: insight into the molecular basis of Wiskott-Aldrich Syndrome | journal = Cell | volume = 111 | issue = 4 | pages = 565–76 | date = Nov 2002 | pmid = 12437929 | doi = 10.1016/S0092-8674(02)01076-0 }}

{{cite journal | vauthors = Sasahara Y, Rachid R, Byrne MJ, de la Fuente MA, Abraham RT, Ramesh N, Geha RS | title = Mechanism of recruitment of WASP to the immunological synapse and of its activation following TCR ligation | journal = Molecular Cell | volume = 10 | issue = 6 | pages = 1269–81 | date = Dec 2002 | pmid = 12504004 | doi = 10.1016/S1097-2765(02)00728-1 }}

{{cite journal | vauthors = Luthi JN, Gandhi MJ, Drachman JG | title = X-linked thrombocytopenia caused by a mutation in the Wiskott-Aldrich syndrome (WAS) gene that disrupts interaction with the WAS protein (WASP)-interacting protein (WIP) | journal = Experimental Hematology | volume = 31 | issue = 2 | pages = 150–8 | date = Feb 2003 | pmid = 12591280 | doi = 10.1016/S0301-472X(02)01023-8 }}

{{cite journal | vauthors = Kinley AW, Weed SA, Weaver AM, Karginov AV, Bissonette E, Cooper JA, Parsons JT | title = Cortactin interacts with WIP in regulating Arp2/3 activation and membrane protrusion | journal = Current Biology | volume = 13 | issue = 5 | pages = 384–93 | date = Mar 2003 | pmid = 12620186 | doi = 10.1016/S0960-9822(03)00107-6 }}

{{cite journal | vauthors = Kim MK, Kim ES, Kim DS, Choi IH, Moon T, Yoon CN, Shin JS | title = Two novel mutations of Wiskott-Aldrich syndrome: the molecular prediction of interaction between the mutated WASP L101P with WASP-interacting protein by molecular modeling | journal = Biochimica et Biophysica Acta | volume = 1690 | issue = 2 | pages = 134–40 | date = Oct 2004 | pmid = 15469902 | doi = 10.1016/j.bbadis.2004.06.007 }}

1 : EVH1 domain