WKSK can refer to:

• WKSK (AM), a radio station (580 AM) licensed to West Jefferson, North Carolina, United States
• WKSK-FM, a radio station (101.9 FM) licensed to South Hill, Virginia, United States

• Renault Vineyard Resort
• Renault Vineyards
• Renault Vineyards Resort
• Renault Vivaquatre
• Renault Vivasport
• Renault WB
• Renault Winery and Resort
• Renault Winery Resort
• Renault Winery & Resort
• Renault–Nissan Common Module Family
• Renault–Nissan–Mitsubishi Alliance
• Renau (river)
• Renavas
• Renavas Manor
• Renavi
• Renavoli-ye Sofla
• Rena Wang
• Renazide
• Renberg
• Renberg Theater
• Renborin
• RENBP (gene)
• Renbök phenomenon
• Renc
• Renca (Argentina)