“Wrch1”的意思、由来-开放百科全书

RhoU (or Wrch1 or Chp2) is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rho family of GTPases.

Wrch1 was identified in 2001 as encoded by a non-canonical Wnt induced gene.^[1]

RhoU/Wrch delineates with RhoV/Chp a Rho subclass related to Rac and Cdc42, which emerged in early multicellular organisms during evolution.^[2]

Model organisms

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.^[5]^[12] Twenty three tests were carried out on mutant mice, but no significant abnormalities were observed.^[5]

References

1. ^{{cite journal |vauthors=Tao W, Pennica D, Xu L, Kalejta RF, Levine AJ |year=2001 |title=Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1 |journal=Genes Dev |volume=15 |issue=14 |pages=1796–807 |issn=0890-9369|doi=10.1101/gad.894301 |pmid=11459829 |pmc=312736}}
2. ^{{cite journal |vauthors=Boureux A, Vignal E, Faure S, Fort P |year=2007 |title=Evolution of the Rho family of ras-like GTPases in eukaryotes |journal=Mol Biol Evol |volume=24 |issue=1 |pages=203–16 |issn=0021-9193 |pmid=17035353 |doi=10.1093/molbev/msl145 |pmc=2665304}}
3. ^{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MBZM/salmonella-challenge/ |title=Salmonella infection data for Rhou |publisher=Wellcome Trust Sanger Institute}}
4. ^{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MBZM/citrobacter-challenge/ |title=Citrobacter infection data for Rhou |publisher=Wellcome Trust Sanger Institute}}
5. ^¹²{{cite journal| doi = 10.1111/j.1755-3768.2010.4142.x| title = The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice| year = 2010| author = Gerdin AK| journal = Acta Ophthalmologica| volume = 88| issue = S248 }}
6. ^Mouse Resources Portal, Wellcome Trust Sanger Institute.
7. ^{{cite web |url=http://www.knockoutmouse.org/martsearch/search?query=Rhou |title=International Knockout Mouse Consortium}}
8. ^{{cite web |url=http://www.informatics.jax.org/searchtool/Search.do?query=MGI:4363423 |title=Mouse Genome Informatics}}
9. ^{{Cite journal| last1 = Skarnes |first1 =W. C.| doi = 10.1038/nature10163 | last2 = Rosen | first2 = B.| last3 = West | first3 = A. P.| last4 = Koutsourakis | first4 = M.| last5 = Bushell | first5 = W.| last6 = Iyer | first6 = V.| last7 = Mujica | first7 = A. O.| last8 = Thomas | first8 = M.| last9 = Harrow | first9 = J.| last10 = Cox | first10 = T.| last11 = Jackson | first11 = D.| last12 = Severin | first12 = J.| last13 = Biggs | first13 = P.| last14 = Fu | first14 = J.| last15 = Nefedov | first15 = M.| last16 = De Jong | first16 = P. J.| last17 = Stewart | first17 = A. F.| last18 = Bradley | first18 = A. | title = A conditional knockout resource for the genome-wide study of mouse gene function | journal = Nature | volume = 474 | issue = 7351 | pages = 337–342 | year = 2011 | pmid = 21677750 | pmc =3572410 }}
10. ^{{cite journal |author=Dolgin E |title=Mouse library set to be knockout |journal=Nature |volume=474 |issue=7351 |pages=262–3 |date=June 2011 |pmid=21677718 |doi=10.1038/474262a }}
11. ^{{cite journal |vauthors=Collins FS, Rossant J, Wurst W |title=A mouse for all reasons |journal=Cell |volume=128 |issue=1 |pages=9–13 |date=January 2007 |pmid=17218247 |doi=10.1016/j.cell.2006.12.018 }}
12. ^{{cite journal|vauthors=van der Weyden L, White JK, Adams DJ, Logan DW | title=The mouse genetics toolkit: revealing function and mechanism. | journal=Genome Biol | year= 2011 | volume= 12 | issue= 6 | pages= 224 | pmid=21722353 | doi=10.1186/gb-2011-12-6-224 | pmc=3218837}}