WRFQ may refer to:

• WRFQ (FM), a radio station (104.5 FM) licensed to Mount Pleasant, South Carolina, United States
• WVQC-LP, a low-power radio station (95.7 FM) licensed to Cincinnati, Ohio, United States, which held the call sign WRFQ-LP from November 2008 to February 2009
• WYRF-LP, a low-power radio station (92.5 FM) licensed to serve Florence, South Carolina, United States, which held the call sign WRFQ-LP in 2014

• 21 Nights with Pattie
• 21 nuits avec Pattie
• 21. Panzer-Division
• 21. Panzer Division
• 21 Party
• (2,1)-Pascal triangle
• 21.Peron
• 21. Peron
• 21 pilots
• 21Pilots
• 21 Pilots discography
• 21-pin EuroSCART
• 21 posyolok
• 21 project
• 21 Project
• 21 Ranchhouse
• 2-1 road
• 21 Sarfarosh - Saragarhi 1897
• 21 Savage
• 21 Savage discography
• 21 Sco
• 21 Scorpii
• 21 Serpentis
• 21(S)-hydroxypromegestone
• 21S-hydroxypromegestone