YRC could mean:

• Yorkshire Ramblers' Club (YRC), a senior mountaineering and caving club based in Yorkshire, England, UK
• York Railway (reporting mark YRC), a short line railroad operating between York and Hanover, Pennsylvania, U.S.
• YRC Worldwide (NASDAQ: YRCW), the combination of Yellow Freight and Roadway Transportation, a Fortune 500 company based in Overland Park, Kansas, U.S.

• Iru Medhaigal
• Iru Methaigal
• Irumpanam
• Irumu language
• Irundiaba
• Irundiaba waorani
• Irundialba
• Irundialba waorani
• Irundisaua
• Irundisaua balteata
• Irundisaua forsteri
• Irundisaua heloisae
• Irundisaua lewisi
• Irundisaua moacyri
• Irundisaua ocularis
• Irundisaua punctata
• Irundisaua ucayalensis
• Irune Murua
• Irungalur
• Irungattukottai
• Irungattukottai Race Track
• Irungbam Khelemba Singh
• I Run (Slim Thug song)
• IRunway
• Iru Phutunqu (Chile-Nor Lipez)