| 词条 | ZM-241,385 |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 360578336 | ImageFile = ZM241385.png | ImageSize = | IUPACName = 4-(2-(7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-ylamino)ethyl)phenol | OtherNames = | Section1 = {{Chembox Identifiers | CASNo_Ref = {{cascite|correct|??}} | CASNo = 139180-30-6 | PubChem = 176407 | IUPHAR_ligand = 405 | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 113142 | SMILES = Oc1ccc(CCNc2nc3nc(c4ccco4)nn3c(N)n2)cc1 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 153646 | InChI = 1/C16H15N7O2/c17-14-20-15(18-8-7-10-3-5-11(24)6-4-10)21-16-19-13(22-23(14)16)12-2-1-9-25-12/h1-6,9,24H,7-8H2,(H3,17,18,19,20,21,22) | InChIKey = PWTBZOIUWZOPFT-UHFFFAOYAJ | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C16H15N7O2/c17-14-20-15(18-8-7-10-3-5-11(24)6-4-10)21-16-19-13(22-23(14)16)12-2-1-9-25-12/h1-6,9,24H,7-8H2,(H3,17,18,19,20,21,22) | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = PWTBZOIUWZOPFT-UHFFFAOYSA-N | Section2 = {{Chembox Properties | C=16|H=15|N=7|O=2 | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = | Section3 = {{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }}ZM-241,385 is a high affinity antagonist ligand selective for the adenosine A2A receptor.[1] In animal models, ZM-241,385 has been shown to protect against beta amyloid neurotoxicity and therefore may be useful as a treatment for Alzheimer's disease.[2] ZM-241,385 has also been shown to enhance L-DOPA derived dopamine release and therefore may be useful in the treatment of Parkinson's disease.[3] References1. ^{{cite journal | vauthors = Palmer TM, Poucher SM, Jacobson KA, Stiles GL | title = 125I-4-(2-(7-amino-2-(2-furyl)(1,2,4)triazolo(2,3-a)(1,3,5) triazin-5-yl-amino)ethyl)phenol, a high affinity antagonist radioligand selective for the A2a adenosine receptor | journal = Molecular Pharmacology | volume = 48 | issue = 6 | pages = 970–4 |date=December 1995 | pmid = 8848012 | doi = | url = http://molpharm.aspetjournals.org/cgi/content/abstract/48/6/970 | issn = | pmc=3479638}} 2. ^{{cite journal | vauthors = Dall'Igna OP, Porciúncula LO, Souza DO, Cunha RA, Lara DR, Dall'lgna OP | title = Neuroprotection by caffeine and adenosine A2A receptor blockade of beta-amyloid neurotoxicity | journal = British Journal of Pharmacology | volume = 138 | issue = 7 | pages = 1207–9 |date=April 2003 | pmid = 12711619 | pmc = 1573785 | doi = 10.1038/sj.bjp.0705185 | url = | issn = }} 3. ^{{cite journal | vauthors = Gołembiowska K, Dziubina A | title = Striatal adenosine A(2A) receptor blockade increases extracellular dopamine release following l-DOPA administration in intact and dopamine-denervated rats | journal = Neuropharmacology | volume = 47 | issue = 3 | pages = 414–26 |date=September 2004 | pmid = 15275831 | doi = 10.1016/j.neuropharm.2004.04.018 | url = | issn = }} External links{{MeshName|ZM+241385}}{{Adenosinergics}}{{nervous-system-drug-stub}} 3 : Phenols|Furans|Adenosine receptor antagonists |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。