词条 | 16S rRNA (adenine1408-N1)-methyltransferase |
释义 |
| Name = 16S rRNA (adenine1408-N1)-methyltransferase | EC_number = 2.1.1.180 | CAS_number = | IUBMB_EC_number = 2/1/1/180 | GO_code = | image = | width = | caption = }}16S rRNA (adenine1408-N1)-methyltransferase ({{EC number|2.1.1.180}}, kanamycin-apramycin resistance methylase, 16S rRNA:m1A1408 methyltransferase, KamB, NpmA, 16S rRNA m1A1408 methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:16S rRNA (adenine1408-N1)-methyltransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction S-adenosyl-L-methionine + adenine1408 in 16S rRNA S-adenosyl-L-homocysteine + N1-methyladenine1408 in 16S rRNA The enzyme provides a panaminoglycoside{{Not a typo}} resistance through interference with the binding of aminoglycosides. References1. ^{{cite journal | vauthors = Beauclerk AA, Cundliffe E | title = Sites of action of two ribosomal RNA methylases responsible for resistance to aminoglycosides | journal = Journal of Molecular Biology | volume = 193 | issue = 4 | pages = 661–71 | date = February 1987 | pmid = 2441068 | doi = 10.1016/0022-2836(87)90349-4 }} 2. ^{{cite journal | vauthors = Koscinski L, Feder M, Bujnicki JM | title = Identification of a missing sequence and functionally important residues of 16S rRNA:m(1)A1408 methyltransferase KamB that causes bacterial resistance to aminoglycoside antibiotics | journal = Cell Cycle | volume = 6 | issue = 10 | pages = 1268–71 | date = May 2007 | pmid = 17495534 | doi = 10.4161/cc.6.10.4231 }} 3. ^{{cite journal | vauthors = Holmes DJ, Drocourt D, Tiraby G, Cundliffe E | title = Cloning of an aminoglycoside-resistance-encoding gene, kamC, from Saccharopolyspora hirsuta: comparison with kamB from Streptomyces tenebrarius | journal = Gene | volume = 102 | issue = 1 | pages = 19–26 | date = June 1991 | pmid = 1840536 | doi = 10.1016/0378-1119(91)90532-g }} 4. ^{{cite journal | vauthors = Wachino J, Shibayama K, Kurokawa H, Kimura K, Yamane K, Suzuki S, Shibata N, Ike Y, Arakawa Y | title = Novel plasmid-mediated 16S rRNA m1A1408 methyltransferase, NpmA, found in a clinically isolated Escherichia coli strain resistant to structurally diverse aminoglycosides | journal = Antimicrobial Agents and Chemotherapy | volume = 51 | issue = 12 | pages = 4401–9 | date = December 2007 | pmid = 17875999 | pmc = 2168023 | doi = 10.1128/aac.00926-07 }} External links
1 : EC 2.1.1 |
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