| 词条 | Nonbacterial thrombotic endocarditis |
| 释义 |
| name = Nonbacterial thrombotic endocarditis | synonyms = | image = | caption = | pronounce = | field = | symptoms = | complications = | onset = | duration = | types = | causes = | risks = | diagnosis = | differential = | prevention = | treatment = | medication = | prognosis = | frequency = | deaths = }}Non-bacterial thrombotic endocarditis (NBTE) is a form of endocarditis in which small sterile vegetations are deposited on the valve leaflets. Formerly known as marantic endocarditis, which comes from the Greek marantikos, meaning “wasting away.”[1] the term "marantic endocarditis" is still sometimes used to emphasize the association with a wasting state[2] such as cancer.[3] Risk factorsMarantic vegetations are often associated with previous rheumatic fever. Other risk factors include:
Valve predilectionThe disease affects the valves with the following predilection: mitral valve > aortic valve > tricuspid valve > pulmonary valve [4] HistopathologyGrossly, vegetations form along lines of valve closure and are generally symmetric with a smooth or verrucoid (warty) texture. Histologically, lesions are composed of fibrin[5] (eosinophilic) and platelets but, unlike bacterial etiologies, contain little evidence of PMNs, microorganisms or inflammation. DiagnosisDue to the non-invasive nature of NBTE, clinical examination may or may not reveal a new murmur. An embolic stroke may be the first feature to suggest the diagnosis of NBTE. An echocardiograph may be used to further assess for valvular lesions. Treatment{{Empty section|date=October 2017}}References1. ^{{EMedicine|article|1165712|Neurological Sequelae of Infectious Endocarditis}} 2. ^{{cite web |url=http://www.merck.com/mmpe/sec07/ch077/ch077c.html#sec07-ch077-ch077b-1476 |title=Noninfective Endocarditis: Endocarditis: Merck Manual Professional |format= |work= |accessdate=2008-12-22}} 3. ^{{cite web |url=http://cancerweb.ncl.ac.uk/cgi-bin/omd?marantic+endocarditis |title=Definition: marantic endocarditis from Online Medical Dictionary |format= |work= |accessdate=2008-12-22}} 4. ^https://www.uptodate.com/contents/nonbacterial-thrombotic-endocarditis 5. ^{{DorlandsDict|nine/000952354|nonbacterial thrombotic endocarditis}} External links{{Medical resources| DiseasesDB = 29250 | ICD10 = | ICD9 = | ICDO = | OMIM = | MedlinePlus = | eMedicineSubj = article | eMedicineTopic = 155230 | MeshID = }}{{Heart diseases}}{{Paraneoplastic syndromes}} 1 : Heart diseases |
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