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词条 Novartis
释义

  1. Corporate structure

  2. Place in its market segments

      Finance  

  3. History

     Ciba-Geigy  Ciba  Geigy  Ciba‑Geigy Ltd  Sandoz  Merger  Post-merger  2000 to 2010  2011 onward  Acquisition history 

  4. Research

  5. Basel headquarters campus redesign

  6. Products

     Pharmaceuticals  Consumer health  Animal health  Pet care  Livestock  Bioprotection (insect and rodent control) 

  7. Controversies and criticism

     Challenge to India's patent laws  Sexual discrimination suit  Marketing violations  Fighting off-label prescribing  Valsartan data scandal  Bribery of Greek officials  Michael Cohen payments 

  8. See also

  9. Notes and references

  10. Further reading

  11. External links

{{Use dmy dates|date=July 2014}}{{coord|47.5744252|7.5764914|display=title}}{{Infobox company
| name = Novartis International AG
| logo = Novartis-Logo.svg
| logo_size =
| image = Industria Novartis.jpg
| image_size = 220px
| image_caption = Novartis headquarters in Basel
| type = Aktiengesellschaft
| traded_as = {{unbulleted list|{{SIX Swiss Exchange|NOVN}}|{{New York Stock Exchange|NVS}}}}
| ISIN = CH0012005267
| founded = {{unbulleted list|{{start date and age|1996}}|(from merger)}}
| location = Basel, Switzerland
| area_served = Worldwide
| key_people = {{unbulleted list|Vasant Narasimhan {{small|(CEO)}}[1]}}
| industry = Pharmaceuticals
| products = Pharmaceuticals, generic drugs, over-the-counter drugs, vaccines, diagnostics, contact lenses, animal health (list...)
| revenue = {{increase}} {{US$|51.900 billion|link=yes}} {{small|(2018)}}[2]
| operating_income = {{decrease}} {{US$|8.169 billion}} {{small|(2018)}}[2]
| net_income = {{increase}} {{US$|12.614 billion}} {{small|(2018)}}[2]
| assets = {{increase}} {{US$|145.563 billion}} {{small|(2018)}}[2]
| equity = {{increase}} {{US$|78.692 billion}} {{small|(2018)}}[2]
| num_employees = 125.161 {{small|(2017)}}[2]
| homepage = {{URL|http://www.novartis.com/}}
| subsid = Ciba Vision, Sandoz, Alcon, Chiron Corporation
}}

Novartis International AG is a Swiss multinational pharmaceutical company based in Basel, Switzerland. It is one of the largest pharmaceutical companies by both market capitalization and sales.

Novartis manufactures the drugs clozapine (Clozaril), diclofenac (Voltaren), carbamazepine (Tegretol), valsartan (Diovan),

imatinib mesylate (Gleevec/Glivec), ciclosporin (Neoral/Sandimmun), letrozole (Femara), methylphenidate (Ritalin), terbinafine (Lamisil), and others.

In 1996, Ciba-Geigy merged with Sandoz; the pharmaceutical and agrochemical divisions of both companies formed Novartis as an independent entity. Other Ciba-Geigy and Sandoz businesses were sold, or, like Ciba Specialty Chemicals, spun off as independent companies. The Sandoz brand disappeared for three years, but was revived in 2003 when Novartis consolidated its generic drugs businesses into a single subsidiary and named it Sandoz. Novartis divested its agrochemical and genetically modified crops business in 2000 with the spinout of Syngenta in partnership with AstraZeneca, which also divested its agrochemical business.

Novartis is a full member of the European Federation of Pharmaceutical Industries and Associations (EFPIA),[3] the International Federation of Pharmaceutical Manufacturers and Associations (IFPMA),[4] and the Pharmaceutical Research and Manufacturers of America (PhRMA).[5]

Corporate structure

Novartis AG is a publicly traded Swiss holding company that operates through the Novartis Group. Novartis AG owns, directly or indirectly, all companies worldwide that operate as subsidiaries of the Novartis Group.[6]{{rp|117}}

Novartis's businesses are divided into three operating divisions: Advanced Accelerator Applications , Alcon (eye care) and Sandoz (generics).[6]{{rp|150}} Novartis operates directly and through dozens of subsidiaries in countries around the world, each of which fall under one of the divisions, and that Novartis categorizes as fulfilling one or more of the following functions: "Holding/Finance: the entity is a holding company and/or performs finance functions for the Group; Sales: the entity performs sales and marketing activities for the Group; Production: the entity performs manufacturing and/or production activities for the Group; and Research: the entity performs research and development activities for the Group."[6]{{rp|251–253}}

Novartis AG also holds 33.3% of the shares of Roche however, it does not exercise control over Roche. Novartis also owned 24.9% of Idenix Pharmaceuticals prior to its sale to Merck & Co, Inc.[6]{{rp|117}} Novartis also has two significant license agreements with Genentech, a Roche subsidiary. One agreement is for Lucentis; the other is for Xolair, both of which Novartis markets outside the US.[6]{{rp|239}}

Novartis has established a multi-functional center in Hyderabad, India, in order to offshore several of its R&D, clinical development, medical writing and administrative functions.[7] The global service centere began in 2001 with 17 people; Hyderabad was chosen from a shortlist of 23 cities, including Pune, Chennai and Gurgaon.[8] The center supports the drug major’s operations in the pharmaceuticals (Novartis), eye care (Alcon) and generic drugs segments (Sandoz). This centre covers more than 870,000 square feet - large enough to house 8000 people.[9]

Place in its market segments

{{Update section|date=September 2018}}

Overall, Novartis was the world's second largest pharmaceutical company in 2011.[10] An IMS Health report ranked Novartis as the biggest pharma company in 2012.[11]

Alcon: Alcon was already the world's largest and most profitable eye care company when Novartis bought it, with 2009 annual sales of $6.5 billion and net income of $2 billion. At that time, Novartis stated that it believed the two companies could generate some $200 million of potential annual pre-tax cost synergies.[12]

Sandoz: {{As of|2013}}, Sandoz was the world's second-largest generic drug company, contributing US$1.09 billion to Novartis' operating profit on US$8.70 billion in revenue in 2012.[13] Sandoz' biosimilars leads its field, getting the first biosimilar approvals in the EU.[14][15] In 2018, Sandoz reported USD $9.9 billion in net sales.[16]

Vaccines and Diagnostics Division: In 2013,Novartis announced it was considering selling this division off. While "sales in the unit were up 14% for the first half of 2013, it reported an operating loss of $240 million in the first half of 2013 after a $250 million loss for all 2012.... Vaccine revenue was $1.4 billion in 2012 and has been forecast to more than double to $3.14 billion by 2018."[17]. In 2014, Novartis announced its intention of selling the Vaccines Division to CSL Limited for $275 million. This sale was completed in late 2015 and the division was integrated into CSL's BioCSL operation with the combined entity trading as Seqirus[18] In June 2018 Novartis sold its consumer healthcare joint venture vaccines division to GlaxoSmithKline for USD 13.0 billion.[19]

Consumer: Novartis is not a leader in the over-the-counter or animal health segments; its leading OTC brands are Excedrin and Theraflu, but sales have been slowed by problems at its key US manufacturing plant.[20]

In 2012, Novartis ranked 7th on the Access to Medicine Index,[21]{{rp|88}} which "ranks companies on how readily they make their products available to the world’s poor."[22] In 2010, Novartis was in the top three pharma companies (as it was in 2008).[22]

Finance

For the fiscal year 2018, Novartis reported earnings of US$12.6 billion, with an annual revenue of US$53.2 billion, an increase of 6.05% over the previous fiscal cycle. Novartis shares traded at over $91 per share, and its market capitalization was valued at over US$209.7B billion in February 2019.[23]

YearRevenue
in mil. USD$		Net income
in mil. USD$		Price per Share
in USD$		Employees
200529,7536,13032.03
200635,1057,17536.99
200738,94711,94637.10
200842,5848,19535.44
200945,1038,40031.98
201051,5619,79439.41
201159,3758,94044.42
201251,9719,27046.50
201352,7169,17561.40135,696
201453,63410,21076.50133,413
201550,38717,78386.92122,966
201649,4366,71271.10122,985
201750,1357,70377.33126,457
201853,16612,61491.13129,924

History

Novartis was created in 1996 from the merger of Ciba-Geigy and Sandoz Laboratories, both Swiss companies with long histories. Ciba-Geigy was formed in 1970 by the merger of J. R. Geigy Ltd (founded in Basel in 1758) and CIBA (founded in Basel in 1859). Combining the histories of the merger partners, the company's effective history spans 250 years.[24]

Ciba-Geigy

Ciba

In 1859, Alexander Clavel (1805–1873) took up the production of fuchsine in his factory for silk-dyeing works in Basel. In 1864, a new site for the production of synthetic dyes was constructed, and in 1873, Clavel sold his dye factory to the new company Bindschedler and Busch. In 1884, Bindschedler and Busch was transformed into a joint-stock company with the name "Gesellschaft für Chemische Industrie Basel" (Company for Chemical Industry Basel). The acronym, CIBA, was adopted as the company's name in 1945.

Geigy

Johann Rudolf Geigy-Gemuseus (1733–1793) began trading in 1758 in "materials, chemicals, dyes and drugs of all kinds"[25][26] in Basel, Switzerland. Johann Rudolf Geigy-Merian (1830–1917) and Johann Muller-Pack acquired a site in Basel in 1857, where they built a dyewood mill and a dye extraction plant. Two years later, they began the production of synthetic fuchsine. In 1901, they formed the public limited company Geigy and the name of the company was changed to J. R. Geigy Ltd in 1914. In 1925, J. R. Geigy Ltd. began producing textile auxiliaries,[27] an activity which Ciba took up in 1928. In 1939, Geigy chemist Paul Hermann Müller discovered that DDT was effective against malaria-bearing insects. He received the 1948 Nobel Prize in Medicine for this work.

Ciba‑Geigy Ltd

CIBA and Geigy merged in 1971 to form Ciba‑Geigy Ltd. {{IPAc-en|ˌ|s|iː|b|ə|_|ˈ|g|aɪ|g|i|}}. In the United States, the Geigy staff relocated to join the CIBA staff at its American headquarters for research in Ardsley, New York. In 1980, Ciba-Geigy set up the company, Ciba Vision, to enter the contact lens market.[28] In 1992 Ciba-Geigy agreed to pay New Jersey $62 million for illegal waste dumping.[29]

Sandoz

{{Redirect|Sandoz}}

Before the 1996 merger with Ciba-Geigy to form Novartis, Sandoz Pharmaceuticals (Sandoz AG) was a pharmaceutical company headquartered in Basel, Switzerland (as was Ciba-Geigy), and was best known for developing drugs such as Sandimmune for organ transplantation, the antipsychotic Clozaril, Mellaril Tablets and Serentil Tablets for treating psychiatric disorders, and Cafergot Tablets and Torecan Suppositories for treating migraine headaches.

The Chemiefirma Kern und Sandoz ("Kern and Sandoz Chemistry Firm") was founded in 1886 by Alfred Kern (1850–1893) and Edouard Sandoz (1853–1928). The first dyes manufactured by them were alizarinblue and auramine. After Kern's death, the partnership became the corporation Chemische Fabrik vormals Sandoz in 1895. The company began producing the fever-reducing drug antipyrin in the same year. In 1899, the company began producing the sugar substitute saccharin. Further pharmaceutical research began in 1917 under Arthur Stoll (1887–1971), who is the founder of Sandoz's pharmaceutical department in 1917.[30] In 1918, Arthur Stoll isolated ergotamine from ergot; the substance was eventually used to treat migraine and headaches and was introduced under the trade name Gynergen in 1921.

Between the World Wars, Gynergen (1921) and Calcium-Sandoz (1929) were brought to market. Sandoz also produced chemicals for textiles, paper, and leather, beginning in 1929. In 1939, the company began producing agricultural chemicals.

The psychedelic effects of lysergic acid diethylamide (LSD) were discovered at the Sandoz laboratories in 1943 by Arthur Stoll and Albert Hofmann.[31][32] Sandoz began clinical trials and marketed the substance, from 1947 through the mid-1960s, under the name Delysid as a psychiatric drug, thought useful for treating a wide variety of mental ailments, ranging from alcoholism to sexual deviancy. Sandoz suggested in its marketing literature that psychiatrists take LSD themselves,[33] to gain a better subjective understanding of the schizophrenic experience, and many did exactly that and so did other scientific researchers. The Sandoz product received mass publicity as early as 1954, in a Time Magazine feature.[34] Research on LSD peaked in the 1950s and early 1960s. Sandoz withdrew the drug from the market in the mid-1960s. The drug became a cultural novelty of the 1960s after psychologist Timothy Leary at Harvard University began to promote its use for recreational and spiritual experiences among the general public.

Sandoz opened its first foreign offices in 1964. In 1967, Sandoz merged with Wander AG (known for Ovomaltine and Isostar). Sandoz acquired the companies Delmark, Wasabröd (a Swedish manufacturer of crisp bread), and Gerber Products Company (a baby food company). On 1 November 1986, a fire broke out in a production plant storage room, which led to the Sandoz chemical spill and a large amount of pesticide being released into the upper Rhine river. This exposure killed many fish and other aquatic life. In 1995, Sandoz spun off its specialty chemicals business to form Clariant. In 1997, Clariant merged with the specialty chemicals business that was spun off from Hoechst AG in Germany.[35]

Merger

In 1996 Ciba-Geigy merged with Sandoz, with the pharmaceutical and agrochemical divisions of both staying together to form Novartis. Other Ciba-Geigy and Sandoz businesses were spun off as independent companies.[36][37] Notably, Ciba Specialty Chemicals was spun out as an independent company,[37][38] and Sandoz's Master Builders Technologies, a producer of chemicals for the construction industry, was sold off to SKW Trostberg A.G., a subsidiary of the German energy company VIAG, while its North American corn herbicide business was sold off to the German chemical maker BASF.[38]

Post-merger

In 1998, the company made headlines with its biotechnology licensing agreement with the University of California at Berkeley Department of Plant and Microbial Biology. Critics of the agreement expressed concern over prospects that the agreement would diminish academic objectivity, or lead to the commercialization of genetically modified plants. The agreement expired in 2003.

2000 to 2010

In 2000, Novartis and AstraZeneca combined their agrobusiness divisions to create a new company, Syngenta.[39][40]

In 2003, Novartis organized all its generics businesses into one division, and merged some of its subsidiaries into one company, reusing the predecessor brand name of Sandoz.[41]

In 2005, Novartis expanded its subsidiary Sandoz significantly through the US$8.29 billion acquisition of Hexal, one of Germany's leading generic drug companies, and Eon Labs, a fast-growing United States generic pharmaceutical company.[42]

In 2006, Novartis acquired the California-based Chiron Corporation. Chiron had been divided into three units: Chiron Vaccines, Chiron Blood Testing, and Chiron BioPharmaceuticals. The biopharmaceutical unit was integrated into Novartis Pharmaceuticals, while the vaccines and blood testing units were made into a new Novartis Vaccines and Diagnostics division.[43] Also in 2006, Sandoz became the first company to have a biosimilar drug approved in Europe with its recombinant human growth hormone drug.[44]

In 2007, Novartis sold the Gerber Products Company to Nestlé as part of its continuing effort to shed old Sandoz and Ciba-Geigy businesses and focus on healthcare.[45]

In 2009, Novartis reached an agreement to acquire an 85% stake in the Chinese vaccines company Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. as part of a strategic initiative to build a vaccines industry leader in this country and expand the group's limited presence in this fast-growing market segment. This proposed acquisition will require government and regulatory approvals in China.[46]

In 2010, Novartis offered to pay US $39.3 billion to fully acquire Alcon, the world's largest eye-care company, including a majority stake held by Nestlé. Novartis had bought 25% of Alcon in 2008.[47] Novartis created a new division and called it Alcon, under which it placed its CIBA VISION subsidiary and Novartis Ophthalmics, which became the second-largest division of Novartis.[48] The total cost for Alcon amounted to $60 billion.

[49]

2011 onward

In 2011, Novartis acquired the medical laboratory diagnostics company Genoptix to "serve as a strong foundation for our (Novartis') individualized treatment programs".[50]

In 2012, the Company cut ~2000 positions in the United States, most in sales, in response to anticipated revenue downturns from the hypertension drug Diovan, which was losing patent protection, and the realization that the anticipated successor to Diovan, Rasilez, was failing in clinical trials.[51] The 2012 personnel reductions follow ~2000 cut positions in Switzerland and the United States in 2011, ~1400 cut positions in the United States in 2010, and a reduction of "thousands" and several site closures in previous years.[52] Also in 2012, Novartis became the biggest manufacturer of generic skin care medicine, after agreeing to buy Fougera Pharmaceuticals for $1.525 billion in cash.[53]

In 2013, the Indian Supreme Court issued a decision rejecting Novartis' patent application in India on the final form of Gleevec, Novartis's cancer drug; the case caused great controversy.[54] In 2013, Novartis was sued again by the US government, this time for allegedly bribing doctors for a decade so that their patients are steered towards the company's drugs.[55]

In January 2014, Novartis announced plans to cut 500 jobs from its pharmaceuticals division.[56] In February 2014, Novartis announced that it acquired CoStim Pharmaceuticals.[57] In May 2014, Novartis bought the rights to market Ophthotech's Fovista (an anti-PDGF aptamer, also being investigated for use in combination with anti-VEGF treatments) outside the United States for up to $1 billion.[58] Novartis will acquire exclusive rights to market the eye drug outside of America while retaining US marketing rights. The company agreed to pay Ophthotech $200 million upfront, and $130 million in milestone payments relating to Phase III trials.[58] Ophthotech is also eligible to receive up to $300 million dependent upon future marketing approval milestones outside of America and up to $400 million relating to sales milestones.[59] In September 2014, Ophthotech received its first $50 million phase III trial milestone payment from Novartis.[60] In April 2014, Novartis announced that it would acquire GlaxoSmithKline's cancer drug business for $16 billion as well as selling its vaccines business to GlaxoSmithKline for $7.1 billion.[61] In August 2014 Genetic Engineering & Biotechnology News reported that Novartis had acquired a 15% stake in Gamida Cell for $35 million, with the option to purchase the whole company for approximately $165 million.[62] In October 2014, Novartis announced its intention to sell its influenza vaccine business (inclusive of its development pipeline), subject to regulatory approval, to CSL for $275 million.[63]

In March 2015, the company announced BioPharma had completed its acquisition of two Phase III cancer-drug candidates; the MEK inhibitor binimetinib (MEK 162) and the BRAF inhibitor encorafenib (LGX818), for $85 million.[64] Further, the company sold its RNAi portfolio to Arrowhead Research for $10 million and $25 million in stock.[65] In June, the company announced it would acquire Spinifex Pharmaceuticals for more than $200 million.[66] In August, the company acquired the remaining rights to the CD20 monoclonal antibody Ofatumumab from GlaxoSmithKline for up to $1 billion.[67][68] In October the company acquired Admune Therapeutics for an undisclosed sum, as well as licensing PBF-509, an adenosine A2A receptor antagonist which is in Phase I clinical trials for non-small cell lung cancer, from Palobiofarma.[69]

In November 2016, the company announced it would acquire Selexys Pharmaceuticals for $665 million.[70] In December, the company acquired Encore Vision, gaining the company's principle compound, EV06, is a first-in-class topical therapy for presbyopia.[71] In December Novartis acquired Ziarco Group Limited, bolstering its presence in eczema treatments.[72]

In late October 2017, Reuters announced that Novartis would acquire Advanced Accelerator Applications for $3.9 billion, paying $41 per ordinary share and $82 per American depositary share representing a 47 percent premium.[73]

In March 2018, GlaxoSmithKline announced that it has reached an agreement with Novartis to acquire Novartis’ 36.5% stake in their Consumer Healthcare Joint Venture for $13 billion (£9.2 billion).[74][75] In April of the same year, the business utilised some of the proceeds from the aforementioned GlaxoSmithKline deal to acquire Avexis for $218 per share or $8.7 billion in total, gaining the lead compound AVXS-101 used to treat spinal muscular atrophy.[76] In August 2018, Novartis signed a deal with Laekna-a Shanghai-based pharmaceutical company for its two clinical-stage cancer drugs.[77] Novartis gave Laekna the exclusive international rights for the drugs that are oral pan-Akt kinase inhibitors namely; afuresertib (ASB138) and uprosertib (UPB795).[78] In mid-October, the company announced it would acquire Endocyte Inc for $2.1 billion ($24 per share) merging it with a newly created subsidiary.[79][80] Endocyte will bolster Novartis' offering in its radiopharmaceuticals business, with Endocyte's first in class candidate 177Lu-PSMA-617 being targeted against metastatic castration-resistant prostate cancer.[81] In late December the company announced it would acquire France-based contract manufacturer, CellforCure from LFB - boosting its capacity to produce cell and gene therapies.[82]

Acquisition history

The following is an illustration of the company's major mergers and acquisitions and historical predecessors (this is not a comprehensive list):

{{clade |thickness=0
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|label1=
|1={{clade
|label1=Ciba-Geigy
(Merged 1996)
|1={{clade
|1=J. R. Geigy Ltd
(Merged 1971)
|2=CIBA
(Merged 1971)
}}
|label2=Sandoz
(Merged 1996)
|2= {{clade
|label1=Sandoz
|1={{clade
|2=Gerber Products Company
(Sold 2007)
|1= {{clade
|label1=
|2=Wasabröd - from 1999 new ownership: Barilla Alimentare S.p.A..
|1= {{clade
|label1=
|2=Delmark
|1= {{clade
|label1=
|1=Kern and Sandoz Chemistry Firm
(Founded 1886)
|2=Wander AG
(Acq 1967)
}}
}}
}}
}}
|2=Clariant
(Spun off 1995)
}}
}}
|label2=
|2= {{clade
|1=Syngenta
(Spun off 2000)
}}
}}
|label2=
|2= {{clade
|1=Hexal
(Acq 2005)
}}
}}
|label2=
|2= {{clade
|1=Eon Labs
(Acq 2005)
}}
}}
|label2=Chiron Corporation
(Acq 2006)
|2= {{clade
|2=PowderJect
(Acq 2003)
|1={{clade
|2=Matrix Pharmaceuticals Inc
(Acq 2002)
|1={{clade
|2=PathoGenesis
(Acq 2001)
|1={{clade
|2=Cetus Oncology
(Restructured after Cetus acquisition)
|3=Biocine Company
(Restructured after Cetus acquisition)
|4=Chiron Diagnostics
(Restructured after Cetus acquisition)
|5=Chiron Intraoptics
(Restructured after Cetus acquisition)
|6=Chiron Technologies
(Restructured after Cetus acquisition)
|1={{clade
|2=Cetus Corporation
|1={{clade
|1=Chiron Corporation
|2=Adatomed GmbH

}} }} }} }} }} }} }}


|label2=
|2= {{clade
|1= Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd
(Acq 2009)

}} }}


|label2= Alcon
(Acq 2010)
|2= {{clade
|1=Alcon
|2=Texas Pharmacal Company
(Acq 1979)

}} }}


|label2=
|2= {{clade
|1= Genoptix
(Acq 2011)

}} }}


|label2=
|2= {{clade
|1= Fougera Pharmaceuticals
(Acq 2012)

}} }}


|label2=
|2= {{clade
|1= CoStim Pharmaceuticals
(Acq 2014)

}} }}


|label2=
|2= {{clade
|1= GlaxoSmithKline
(Cancer drug div, Acq 2014)

}} }}


|label2=
|2= {{clade
|1= Spinifex Pharmaceuticals
(Acq 2015)

}} }}


|label2=
|2= {{clade
|1= Admune Therapeutic
(Acq 2015)

}} }}


|label2=
|2= {{clade
|1= Selexys Pharmaceuticals
(Acq 2016)

}} }}


|label2=
|2= {{clade
|1= Selexys Pharmaceuticals
(Acq 2016)

}} }}


|label2=
|2= {{clade
|1= Ziarco Group Limited
(Acq 2016)

}} }}


|label2=
|2= {{clade
|1= Advanced Accelerator Applications
(Acq 2018)

}} }}


|label2=
|2= {{clade
|1= AveXis
(Acq 2018)

}} }}


|label2=
|2= {{clade
|1= Endocyte
(Acq 2018)

}} }}


|label2=
|2= {{clade
|1= CellforCure
(Acq 2018)

}} }} }}

Research

The company's global research operations, called "Novartis Institutes for BioMedical Research (NIBR)" have their global headquarters in Cambridge, Massachusetts, United States.[83][84] Two research institutes reside within NIBR that focus on diseases in the developing world: Novartis Institute for Tropical Diseases, which works on tuberculosis, dengue, and malaria, and Novartis Vaccines Institute for Global Health, which works on salmonella typhi (typhoid fever) and shigella.[85]

Novartis is also involved in publicly funded collaborative research projects, with other industrial and academic partners. One example in the area of non-clinical safety assessment is the InnoMed PredTox project.[86][87] The company is expanding its activities in joint research projects within the framework of the Innovative Medicines Initiative of EFPIA and the European Commission.[88]

Novartis is working with Science 37 in order to allow video based telemedicine visits instead of physical traveling to clinics for patients. It is planning for ten clinical trials over three years using mobile technology to help free patients from burdensome hospital trips.[89]

Basel headquarters campus redesign

An ongoing Basel Campus Project has the aim to transform Novartis headquarters in Basel "from an industrial complex to a place of innovation, knowledge, and encounter".[90] The pharmaceutical giant decided to transform the existing Sandoz office buildings and chemical factories of its headquarters in 2001.

In 1999, PWP Landscape Architecture won the competition for a landscape master plan that would transform a 51-acre site beside the Rhine River from a paved industrial landscape crisscrossed with train tracks into a modern—and largely pedestrian—research and administrative campus filled with outdoor art, trees, greens, and parks. The plan also dealt with an extensive network of existing underground infrastructure.[91]

The buildings were gradually demolished and replaced with works by architects and artists of international stature. Frank Gehry, Rafael Moneo, and from SANAA, Kazuyo Sejima and Ryue Nishizawa were among the architects and Jenny Holzer and Richard Serra among the artists. Marked diversity of forms now dominates the campus. Novel features and technologies were introduced by Gehry to conform to the building standards of the Swiss government that prohibit air-conditioning, while still selecting a contemporary style of massive use of glass exteriors. One adaptation by the architect includes the integration of a building vent, teepee-style, through the roof, which creates a chimney effect that draws cool air in at the lower levels and vents warmer air.

Products

Pharmaceuticals

NameIndication(s) or drug type/class1 million|USDSales year% ChangeNotes
Aclasta/Reclast (zoledronic acid)Osteoporosis590 2012[105] −4%
Adelphane-Esidrex (reserpine/dihydralazine/hydrochlorothiazide)Hypertension
Afinitor/Certican/Zortress (everolimus)Prevention of transplant rejection, various cancers797 2012[105] 80%
Amturnide (aliskiren/amlodipine/hydrochlorothiazide)Hypertension
Anafranil (clomipramine)Major depressive disorder, obsessive-compulsive disorder
Arcapta Neohaler/Onbrez Breezhaler (indacaterol)COPD
Brinaldix (clopamide)Hypertension
Clozaril/Leponex (clozapine)Treatment-resistant schizophrenia
Co-Diovan (Valsartan/hydrochlorothiazide)Hypertension
Coartem/Riamet (artemether/lumefantrine)Malaria (uncomplicated)
Comtan (entacapone)Parkinson's disease5302012[105] −14%
Cosentyx (secukinumab)Psoriasis
Diovan (valsartan)Hypertension4,4172012[105]−22%
Entresto (sacubitril/valsartan)Heart failure
Enterovioform (clioquinol)Amoebiasis
Eucreas/Galvus Met (vildagliptin/metformin)Diabetes mellitus type 2
Exelon Patch (rivastigmine)Alzheimer's disease1,0502012[105]−2%
Exforge (amlodipine/valsartan)Hypertension1,352 2012[105] 12%
Exjade (deferasirox)Chronic iron overload8702012[105]2% Manufactured as tablets for oral suspension; tablets for oral use are marketed under the brand name Jadenu
Famvir (famciclovir)Herpes zoster and other Herpesvirus infection
Fanapt (iloperidone)Schizophrenia
Femara (letrozole)Breast cancer4382012[105] −52%
Focalin (dexmethylphenidate)ADHDFirst US generics of Focalin became available in 2007[92] Focalin XR became available in 2012.[93]
Foradil/Foradile (formoterol)Asthma, COPD
Galvus (vildagliptin)Diabetes mellitus type 2910 2012[105] 39%
Gilenya (fingolimod)Multiple sclerosis1,195 2012[105]142%
Gleevec/Glivec (imatinib)Oncology, Chronic myelogenous leukemia4,6752012[94] 0%
Hygroton (chlortalidone)Hypertension
Ilaris (canakinumab)Cryopyrin-associated periodic syndrome
Jadenu (deferasirox)Chronic iron overload Deferasirox tablets for oral use—a new formulation of Exjade (which comes in tablets for oral suspension)
Jakavi/Jakafi (ruxolitinib)Myelofibrosis (of intermediate to high risk)
Kymriah (tisagenlecleucel) Acute lymphoblastic leukemia
Lamisil (terbinafine)Fungal infections
Lescol (fluvastatin)Hypercholesterolemia6652007[95]−8%
Lioresal (baclofen)Spasticity
Lotrel (amlodipine/benazepril)Hypertension7482007[95]−34%
Lucentis (ranibizumab)Age-related macular degeneration 2,398 2012[94]17%
Ludiomil (maprotiline)Major depressive disorder
Mellaril (thioridazine)Schizophrenia
Myfortic (mycophenolic acid)Prevention of transplant rejection579 2012[94] 12%
Navoban (tropisetron)Chemotherapy-induced nausea and vomiting
Odomzo (sonidegib)Locally advanced basal cell carcinoma
Ritalin (methylphenidate)ADHD5542012[94]1%
Sandimmune/Neoral (ciclosporin)Prevention of transplant rejection8212012[94]−9%
Sandostatin (octreotide)Acromegaly1,5122012[94]5%
Sertraline Sandoz (sertraline hydrochloride)Depression, obsessive-compulsive disorder, panic disorder[96]Generic form of sertraline.
Signifor (pasireotide)Cushing's disease[97][98]
Simulect (basiliximab)Prevention of transplant rejection
Sirdalud (tizanidine)Spasticity
Spersallerg (antazoline/tetrahydrozoline)Allergic conjunctivitis
Stalevo (carbidopa/levodopa/entacapone)Parkinson's disease
Tasigna (nilotinib)Chronic myelogenous leukemia (first-line treatment[99])998 2012[94] 39% NICE formulary approval, January 2012[99]
Tegretol (carbamazepine)Epilepsy, bipolar disorder4132007[95]6%
Tekamlo (aliskiren/amlodipine)Hypertension
Tekturna/Rasilez (aliskiren)Hypertension
Termalgin (paracetamol)Fever, mild pain
Tobi (tobramycin)Prevention of Pseudomonas aeruginosa infection in cystic fibrosis350 (US only)2012[132]Teva introduced generic in the US in 2013[100]
Tofranil (imipramine)Major depressive disorder, enuresis
Trileptal (oxcarbazepine)Epilepsy, bipolar disorder690 (US only)2007[134]Teva introduced generic in 2008[101]
Tyzeca/Sebivo (telbivudine)Chronic hepatitis B
Visudyne (verteporfin)Age-related macular degeneration (wet form)
Voltaren (diclofenac)Acute pain, inflammatory disorders (such as rheumatoid arthritis)759 (excl. OTC)2012[94]−4%
Zometa (zoledronic acid)Prevention of bone fractures in cancer patients1,2882012[94]−13%
Xolair (omalizumab)Moderate-to-severe asthma not controlled by inhaled steroids
Chronic idiopathic urticaria		504 2012[94] 4%
Zaditen (ketotifen)Asthma, allergic conjunctivitis

Consumer health

{{div col|colwidth=22em}}
  • Benefiber
  • Bialcol Alcohol
  • Buckley's cold and cough formula
  • Bufferin
  • ChestEze
  • Comtrex cold and cough
  • Denavir/Vectavir
  • Desenex
  • Doan's pain relief
  • Ex-Lax
  • Excedrin
  • Fenistil
  • Gas-X
  • Habitrol
  • Keri skin care
  • Lamisil foot care
  • Lipactin herpes symptomatic treatment
  • Maalox
  • Nicotinell
  • No-doz
  • Quinvaxem (Pentavalent vaccine)
  • Otrivine
  • Prevacid 24HR
  • Savlon
  • Tavist
  • Theraflu
  • Vagistat
  • Tixylix
  • Voltaren
{{div col end}}

In January 2009, the United States Department of Health and Human Services awarded Novartis a $486 million contract for construction of the first US plant to produce cell-based influenza vaccine, to be located in Holly Springs, North Carolina. The stated goal of this program is the capability of producing 150,000,000 doses of pandemic vaccine within six months of declaring a flu pandemic.[102]

In April 2014, Novartis divested its consumer health section with $3,5 billion worth of assets into a new joint venture with GlaxoSmithkline, named GSK Consumer Healthcare, of which Novartis will hold a 36,5% stake.[103] In March 2018, GSK announced that it has reached an agreement with Novartis to acquire Novartis’ 36.5% stake in their Consumer Healthcare Joint Venture for $13 billion (£9.2 billion).[75]

Animal health

Pet care

  • Interceptor (Milbemycin oxime), oral worm control product
  • Sentinel Flavor Tabs (Milbemycin oxime, Lufenuron), oral flea control product
  • Deramaxx (Deracoxib), oral treatment for pain and inflammation from osteoarthritis in dogs
  • Capstar (Nitenpyram), oral tablet for flea control
  • Milbemax (Milbemycin oxime, Praziquantel), oral worm treatment
  • Program (Lufenuron), oral tablet for flea control

Livestock

  • Acatalk Duostar (Fluazuron, Ivermectin), tick control for cattle
  • CLiK (Dicyclanil), blowfly control for sheep
  • Denagard (Tiamulin), antibiotic for the treatment of swine dysentery associated with Brachyspira (formerly Serpulina or Treponema)
  • Fasinex (Triclabendazole), oral drench for cattle that is used for the treatment and control of all three stages of liver fluke
  • ViraShield, For use in healthy cattle, including pregnant cows and heifers, as an aid in the prevention of disease caused by infectious bovine rhinotracheitis (IBR), bovine virus diarrhoea (BVD Type 1 and BVD Type 2), parainfluenza Type 3 (PI3), and bovine respiratory syncytial (BRSV) viruses

Bioprotection (insect and rodent control)

  • Actara (Thiamenthoxam)
  • Atrazine (Atrazine)
  • Larvadex (Cyromazine)
  • Neporex (Cyromazine)
  • Oxyfly (Lambda-cyhalothrin)
  • Virusnip (Potassium monopersulfate)

Controversies and criticism

Challenge to India's patent laws

{{Main|Novartis v. Union of India & Others}}

Novartis fought a seven-year, controversial battle to patent Gleevec in India, and took the case all the way to the Indian Supreme Court, where the patent application was finally rejected. The patent application at the center of the case was filed by Novartis in India in 1998, after India had agreed to enter the World Trade Organization and to abide by worldwide intellectual property standards under the TRIPS agreement. As part of this agreement, India made changes to its patent law; the biggest of which was that prior to these changes, patents on products were not allowed, while afterwards they were, albeit with restrictions. These changes came into effect in 2005, so Novartis' patent application waited in a "mailbox" with others until then, under procedures that India instituted to manage the transition. India also passed certain amendments to its patent law in 2005, just before the laws came into effect, which played a key role in the rejection of the patent application.[54]

The patent application[104][105] claimed the final form of Gleevec (the beta crystalline form of imatinib mesylate).[106]{{rp|3}} In 1993, before India allowed patents on products, Novartis had patented imatinib, with salts vaguely specified, in many countries but could not patent it in India.[107][108] The key differences between the two patent applications were that the 1998 patent application specified the counterion (Gleevec is a specific salt - imatinib mesylate) while the 1993 patent application did not claim any specific salts nor did it mention mesylate, and the 1998 patent application specified the solid form of Gleevec - the way the individual molecules are packed together into a solid when the drug itself is manufactured (this is separate from processes by which the drug itself is formulated into pills or capsules) - while the 1993 patent application did not. The solid form of imatinib mesylate in Gleevec is beta crystalline.[109]

As provided under the TRIPS agreement, Novartis applied for Exclusive Marketing Rights (EMR) for Gleevec from the Indian Patent Office and the EMR was granted in November 2003.[110] Novartis made use of the EMR to obtain orders against some generic manufacturers who had already launched Gleevec in India.[150] Novartis set the price of Gleevec at USD 2666 per patient per month; generic companies were selling their versions at USD 177 to 266 per patient per month.[111] Novartis also initiated a program to assist patients who could not afford its version of the drug, concurrent with its product launch.[112]

When examination of Novartis' patent application began in 2005, it came under immediate attack from oppositions initiated by generic companies that were already selling Gleevec in India and by advocacy groups. The application was rejected by the patent office and by an appeal board. The key basis for the rejection was the part of Indian patent law that was created by amendment in 2005, describing the patentability of new uses for known drugs and modifications of known drugs. That section, Paragraph 3d, specified that such inventions are patentable only if "they differ significantly in properties with regard to efficacy."[113][114] At one point, Novartis went to court to try to invalidate Paragraph 3d; it argued that the provision was unconstitutionally vague and that it violated TRIPS. Novartis lost that case and did not appeal.[115] Novartis did appeal the rejection by the patent office to India's Supreme Court, which took the case.

The Supreme Court case hinged on the interpretation of Paragraph 3d. The Supreme Court decided that the substance that Novartis sought to patent was indeed a modification of a known drug (the raw form of imatinib, which was publicly disclosed in the 1993 patent application and in scientific articles), that Novartis did not present evidence of a difference in therapeutic efficacy between the final form of Gleevec and the raw form of imatinib, and that therefore the patent application was properly rejected by the patent office and lower courts.[116]

Although the court ruled narrowly,[117] and took care to note that the subject application was filed during a time of transition in Indian patent law,[118] the decision generated widespread global news coverage and reignited debates on balancing public good with monopolistic pricing, innovation with affordability etc.[119][120][121]

Had Novartis won and had its patent issued, it could not have prevented generics companies in India from selling generic Gleevec, but it could have obliged them to pay a reasonable royalty under a grandfather clause included in India's patent law.[122][123]

In reaction to the decision, Ranjit Shahani, vice-chairman and managing director of Novartis India Ltd was quoted as saying "This ruling is a setback for patients that will hinder medical progress for diseases without effective treatment options."[124] He also said that companies like Novartis would invest less money in research in India as a result of the ruling.[54] Novartis also emphasised that it continues to be committed to good access to its drugs; according to Novartis, by 2013, "95% of patients in India—roughly 16,000 people—receive Glivec free of charge... and it has provided more than $1.7 billion worth of Glivec to Indian patients in its support program since it was started...."[112]

Sexual discrimination suit

On 17 May 2010, a jury in the United States District Court for the Southern District of New York awarded $3,367,250 in compensatory damages against Novartis, finding that the company had committed sexual discrimination against twelve female sales representatives and entry-level managers since 2002, in matters of pay, promotion, and treatment after learning that the employees were pregnant. Two months later the company settled with the remaining plaintiffs for $152.5 million plus attorney fees.[125]

Marketing violations

In September 2008, the US Food and Drug Administration (FDA) sent a notice to Novartis Pharmaceuticals regarding its advertising of Focalin XR, an ADHD drug, in which the company overstated its efficacy while marketing to the public and medical professionals.[126]

In 2005, federal prosecutors opened an investigation into Novartis' marketing of several drugs: Trileptal, an antiseizure drug; three drugs for heart conditions - Diovan (the company’s top-selling product), Exforge, and Tekturna; Sandostatin, a drug to treat a growth hormone disorder; and Zelnorm, a drug for irritable bowel syndrome.[169] In September 2010, Novartis agreed to pay US$422.5 million in criminal and civil claims and to enter into a corporate integrity agreement with the US Office of the Inspector General.[127] According to The New York Times, "Federal prosecutors accused Novartis of paying illegal kickbacks to health care professionals through speaker programs, advisory boards, entertainment, travel and meals. But aside from pleading guilty to one misdemeanor charge of mislabeling in an agreement that Novartis announced in February, the company denied wrongdoing."[128] In the same New York Times article, Frank Lichtenberg, a Columbia professor who receives pharmaceutical financing for research on innovation in the industry, said off-label prescribing was encouraged by the American Medical Association and paid for by insurers, but off-label marketing was clearly illegal. "So it’s not surprising that they would settle because they don’t have a legal leg to stand on."

In April 2013, federal prosecutors filed two lawsuits against Novartis under the False Claims Act for off-label marketing and kickbacks; in both suits, prosecutors are seeking treble damages.[129][130] The first suit "accused Novartis of inducing pharmacies to switch thousands of kidney transplant patients to its immunosuppressant drug Myfortic in exchange for kickbacks disguised as rebates and discounts".[129] In the second, the Justice Department joined a qui tam, or whistleblower, lawsuit brought by a former sales rep over off-label marketing of three drugs: Lotrel and Valturna (both hypertension drugs), and the diabetes drug, Starlix.[130] Twenty-seven states, the District of Columbia and Chicago and New York also joined.[129]

Fighting off-label prescribing

Outside the US, Novartis markets the drug ranibizumab (trade name Lucentis), which is a monoclonal antibody fragment derived from the same parent mouse antibody as bevacizumab (Avastin). Both Avastin and Lucentis were created by Genentech which is owned by Roche; Roche markets Avastin worldwide, and also markets Lucentis in the US. Lucentis has been approved worldwide as a treatment for wet macular degeneration and other retinal disorders; Avastin is used to treat certain cancers. Because the price of Lucentis is much higher than Avastin, many ophthalmologists began having compounding pharmacies formulate Avastin for administration to the eye, and began treating their patients with Avastin.[131] In 2011, four trusts of the National Health Service in the UK issued policies approving use and payment for administering Avastin for macular degeneration, in order to save money, even though Avastin had not been approved for that indication.[132] In April 2012, after failing to persuade the trusts that it was uncertain whether Avastin was as safe and effective as Lucentis, and in order to retain the market for Lucentis, Novartis announced it would sue the trusts.[132][133] However, in July Novartis offered significant discounts (kept confidential) to the trusts, and the trusts agreed to change their policy,[134] and in November, Novartis dropped the litigation.[135]

Valsartan data scandal

In the summer of 2013, two Japanese universities retracted several publications of clinical trials that purported to show that Valsartan (branded as Diovan) had cardiovascular benefits, when it was found that statistical analysis had been manipulated, and that a Novartis employee had participated in the statistical analysis but had not disclosed his relationship with Novartis but only his affiliation with Osaka City University, where he was a lecturer.[136]

[137] As a result, several Japanese hospitals stopped using the drug, and media outlets ran reports on the scandal in Japan.[136] In January 2014 Japan's Health Ministry filed a criminal complaint with the Tokyo public prosecutor's office against Novartis and an unspecified number of employees, for allegedly misleading consumers through advertisements that used the research to support the benefits of Diovan.[138] On 1 July 2014 the prosecutor's office announced it was formally charging the company and one of its employees.[139]

Bribery of Greek officials

In January 2018, Novartis began being investigated by Greek authorities for allegedly bribing public officials in the 2006-2015 period. Two former prime ministers, former ministers served in the ministries of health and economy, and bankers are included in the case,[140] while the current manager of Novartis is banned from leaving the country.[141] The minister's deputy described the allegations as "the biggest scandal since the creation of the Greek state", which caused "annual state expenditure on medicine to explode".[142] Most of the ministers involved in the scandal have denied the allegations, calling the case "political targeting" and "bullying".[140] Besides bribery that involves artificial increases in the price of several medicines, the case also involves money laundering, with suspicions of "illegal funds of more than four billion euros ($4.2 billion)" were involved.[143]

Michael Cohen payments

Novartis paid $1.2 million to Essential Consultants, an entity owned by Michael Cohen, following the 2017 inauguration of Donald Trump. Cohen was paid monthly, with each payment just under $100,000. Novartis claims it paid Cohen to help it understand and influence the new administration's approach to drug pricing and regulation.[144]

In July 2018, the US Senate committee report "White House Access for Sale" revealed that Novartis Ag's relationship with Cohen was "longer and more detailed". Novartis initially stated that the relationship ceased a month after entering the USD 1.2 million contract with Cohen's consulting firm since the consultants were not able to provide the information the pharmaceutical company needed. Later, it became clear, however, that then-CEO Joseph Jimenez and Cohen communicated via email multiple times during 2017, which included ideas to lower drug prices to be discussed with the president. According to the report, several of the ideas appeared later in Trump's drug pricing plan, released in early 2018, in which pharmaceutical companies were protected from reduced revenues.[145][146]

See also

  • List of pharmaceutical companies
  • Pharmaceutical industry in Switzerland

Notes and references

1. ^{{Cite news |url=https://www.seattletimes.com/business/novartis-1q-profit-jumps-12-percent-as-heart-drug-sales-soar/ |title=Novartis 1Q profit jumps 12 percent as heart drug sales soar |last= |date=19 April 2018 |work=The Seattle Times |access-date=2018-04-20 |agency=Associated Press |department=Business }}
2. ^1 2 3 4 5 {{cite web |url=https://www.novartis.com/sites/www.novartis.com/files/novartis-annual-report-2018-en.pdf |format=PDF |title=Novartis Annual Report 2018 }}
3. ^{{cite news |url=http://www.efpia.eu/content/default.asp?PageID=559&DocID=4883 |title=The Pharmaceutical Industry in Figures - 2008 Edition |publisher=European Federation of Pharmaceutical Industries and Associations (EFPIA) |format=PDF |page=49 |accessdate=2008-08-25 |deadurl=yes |archiveurl=https://archive.today/20080916100937/http://www.efpia.eu/content/default.asp?PageID=559&DocID=4883 |archivedate=16 September 2008 |df=dmy-all }}
4. ^IFPMA Member List {{webarchive |url=https://web.archive.org/web/20140207235721/http://www.ifpma.org/about-ifpma/members/companies.html |date=7 February 2014 }}
5. ^PhRMA Member List {{webarchive |url=https://web.archive.org/web/20131006232747/http://www.phrma.org/about/member-companies |date=6 October 2013 }}
6. ^1 2 3 4 {{cite web|url=http://www.novartis.com/downloads/investors/reports/novartis-annual-report-2012-en.pdf|title=Annual Report and 20-F Archive - Novartis|website=Novartis|accessdate=6 February 2018}}
7. ^{{cite web|url=http://www.fiercepharma.com/story/nzz-novartis-will-cut-or-move-4000-jobs-many-india/2014-02-02|title=Novartis slashing thousands more jobs in global reorganization, shifting many to India|work=FiercePharma}}
8. ^{{cite web|url=http://www.thehindubusinessline.com/companies/novartis-consolidates-global-services-operations-at-hyderabad-centre/article8005067.ece|title=Novartis consolidates global services operations at Hyderabad centre|author=PT Jyothi Datta|work=The Hindu Business Line}}
9. ^{{cite web|url=http://articles.economictimes.indiatimes.com/2014-01-03/news/45837010_1_novartis-india-office-space-chiron-behring-vaccines|title=Novartis India strikes 8.7 lakh square feet office space deal in Hyderabad|work=timesofindia-economictimes}}
10. ^Staff, EP Vantage. 25 April 2012 [https://archive.today/20131019213152/http://www.evaluategroup.com/Universal/View.aspx?type=Story&id=292308&isEPVantage=yes Novartis on track to become world's biggest drug maker]
11. ^Carolyn Gauntlett and Sarah Rickwood for IMS Health. 2013. The changing face of the top 10 pharmaceutical companies
12. ^Melly Alazraki for Daily Finance. 26 August 2010 Novartis Completes Purchase of Alcon Majority Stake from Nestle {{webarchive |url=https://web.archive.org/web/20131020122219/http://www.dailyfinance.com/2010/08/26/novartis-alcon-buy-majority-stake-nestle/ |date=20 October 2013 }}
13. ^Staff, Generics Bulletin. 7 June 2013 [https://www.sandoz.com/assets/media/shared/documents/Gen_7_6_13_Sandoz_article.pdf Novartis difference puts Sandoz in prime position]{{dead link|date=February 2018 |bot=InternetArchiveBot |fix-attempted=yes }}
14. ^Reuters, 21 October 2010 Biosimilars take off at Novartis generics unit {{webarchive |url=https://web.archive.org/web/20131020160617/http://uk.reuters.com/article/2010/10/21/novartis-biosimilars-idUKLDE69K10V20101021?pageNumber=1 |date=20 October 2013 }}
15. ^Staff, Generics and Biosimilars Initiative, 9 November 2012 Sandoz starts phase III US trial for biosimilar epoetin alfa {{webarchive |url=https://web.archive.org/web/20131020092834/http://www.gabionline.net/Biosimilars/Research/Sandoz-starts-phase-III-US-trial-for-biosimilar-epoetin-alfa |date=20 October 2013 }}
16. ^{{Cite web|url=https://www.sec.gov/Archives/edgar/data/1114448/000137036819000002/a19013020f.htm|title=20-F|last=|first=|date=|website=www.sec.gov|page=63|archive-url=|archive-date=|dead-url=|access-date=2019-03-11}}
17. ^Eric Palmer for FiercePharma, 11 October 2013 Novartis whacks vaccine jobs as it eyes unit for disposal {{webarchive |url=https://web.archive.org/web/20131014061810/http://www.fiercepharma.com/story/novartis-whacks-vaccine-jobs-it-eyes-unit-disposal/2013-10-11#ixzz2iCdt46qQ |date=14 October 2013 }}
18. ^{{Cite web|url=https://www.seqirus.com/newsroom/CSL-completes-Novartis-influenza-vaccine-acquisition-Germany|title=CSL completes Novartis influenza vaccine acquisition in Germany|website=www.seqirus.com|access-date=2019-01-09}}
19. ^{{Cite web|url=https://finance.yahoo.com/news/glaxo-gsk-buys-novartis-apos-131201109.html|title=Glaxo (GSK) Buys Novartis' Stake in Consumer Healthcare JV|website=finance.yahoo.com|language=en-US|access-date=2019-03-11}}
20. ^Staff and wire reports for the Journal Star (LIncoln, Nebraska) 14 August 2013 Novartis reviews business; analyst urges selling OTC unit
21. ^Staff, WHO. Access to Medicine Index, 2012
22. ^1 Donald G McNeil Jr for The New York Times. 28 June 2010 [https://www.nytimes.com/2010/06/29/health/29glob.html?_r=0 The Drug Industry: GlaxoSmithKline, Merck and Novartis Again Rank Highest on Access to Poor]
23. ^{{Cite web|url=https://www.macrotrends.net/stocks/charts/NVS/novartis-ag/revenue|title=Novartis AG Revenue 2006-2018 {{!}} NVS|website=www.macrotrends.net|access-date=2019-03-11}}
24. ^{{Citation |title=Company history |work=corporate website |at=novartis.com |publisher=Novartis |url=http://www.novartis.com/about-novartis/company-history/index.shtml |deadurl=yes |archiveurl=https://web.archive.org/web/20101230203847/http://www.novartis.com/about-novartis/company-history/index.shtml |archivedate=30 December 2010 |df=dmy }}
25. ^{{cite web|url=http://ciba.com/index/cmp-index/cmp-about/cmp-abo-history.htm |archiveurl=https://web.archive.org/web/20100103182548/http://ciba.com/index/cmp-index/cmp-about/cmp-abo-history.htm |archivedate=2010-01-03 |title=Archive of Ciba, now a part of BASF: History |publisher=Ciba.com |date= |accessdate=2013-05-27}}
26. ^Staff, The Mineralogical Record Biographical Archive. J.R. Geigy (1830-1917) {{webarchive |url=https://web.archive.org/web/20131022025913/http://www.minrec.org/labels.asp?colid=765 |date=22 October 2013 }}
27. ^"Textile auxiliaries" are in the class of specialty chemicals and "enable a processing operation in preparation, dyeing, printing, or finishing to be carried out more effectively or which is essential if a given effect is to be obtained. Certain Textile Auxiliaries are also required in order to produce special finishing effects such as wash & wear, water repellence, flame retardancy, aroma finish, anti odour, colour deepening etc." (from Handbook on Textile Auxiliaries, Dyes and Dye Intermediates Technology {{webarchive|url=https://web.archive.org/web/20131022065700/http://www.niir.org/books/book/isbn-HandbookonTextileAuxiliaries%2CDyesandDyeIntermediatesTechnology/zb%2C%2C16c%2Ca%2C0%2C0%2Ca/index.html |date=22 October 2013 }}, by the NPCS Board of Consultants & Engineers. Asia Pacific Business Press Inc., 2009.
28. ^Ciba Vision "About us" page {{webarchive |url=https://web.archive.org/web/20130912023933/http://www.cibavision.com/about-us/overview.shtml |date=12 September 2013 }}
29. ^{{cite news|author=JOSEPH F. SULLIVANPublished: 29 February 1992 |url=https://www.nytimes.com/1992/02/29/nyregion/ciba-to-pay-new-jersey-for-illegal-waste-dumping.html |title=Ciba to Pay New Jersey For Illegal Waste Dumping - New York Times |publisher=Nytimes.com |date=1992-02-29 |accessdate=2013-04-29}}
30. ^{{cite web|author=Monday - Friday,8:30 - 17:00, GMT+1(Central European Time) |url=http://www.novartis.com/about-novartis/company-history/index.shtml |title=Company history |publisher=Novartis.com |date=2010-12-15 |accessdate=2012-01-16 |archiveurl=https://web.archive.org/web/20101230203847/http://www.novartis.com/about-novartis/company-history/index.shtml |archivedate=30 December 2010 |deadurl=yes |df=dmy }}
31. ^{{cite web|url=http://www.nysun.com/obituaries/albert-hofmann-102-invented-lsd/75591/ |title=Albert Hofmann, 102, Invented LSD - The New York Sun |publisher=Nysun.com |date= |accessdate=2013-10-23| archiveurl = https://web.archive.org/web/20131020203430/http://www.nysun.com/obituaries/albert-hofmann-102-invented-lsd/75591/ | archivedate = 2013-10-20| deadurl=no}}
32. ^{{cite web|url=https://www.google.com/patents/US2438259|title=Patent US2438259 - D-lysergic acid diethyl amide|work=google.com}}
33. ^{{cite web|url=http://www.flashback.se/archive/my_problem_child/chapter4.html#2 |title=Albert Hofmann: LSD - My Problem Child: Use of LSD in Psychiatry |publisher=Flashback.se |date= |accessdate=2012-01-16| archiveurl = https://web.archive.org/web/20060707201805/http://www.flashback.se/archive/my_problem_child/chapter4.html | archivedate = 2006-07-07| deadurl=yes}}
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35. ^Anna Bálint: Clariant clareant. The beginnings of a specialty chemicals company, Campus Verlag, Frankfurt am Main/New York 2012, {{ISBN|978-3-593-39374-2}}.
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112. ^1 R. Jai Krishna and Jeanne Whalen for The Wall Street Journal. 1 April 2013 [https://online.wsj.com/news/articles/SB10001424127887323296504578395672582230106 Novartis Loses Glivec Patent Battle in India]
113. ^1 Shamnad Basheer for Spicy IP 11 March 2006 First Mailbox Opposition (Gleevec) Decided in India {{webarchive |url=https://web.archive.org/web/20131021162820/http://spicyip.com/2006/03/first-mailbox-opposition-gleevec.html |date=21 October 2013 }}
114. ^[https://www.scribd.com/doc/133340456/IPAB-Order-Dated-26-Jun-2009-in-Novartis-v-Union-of-India Intellectual Property Appellate Board decision dated 26 June 2009, p 149] {{webarchive |url=https://web.archive.org/web/20131022185309/http://www.scribd.com/doc/133340456/IPAB-Order-Dated-26-Jun-2009-in-Novartis-v-Union-of-India |date=22 October 2013 }}
115. ^W.P. No.24759 of 2006 {{webarchive |url=https://web.archive.org/web/20131020071414/http://judis.nic.in/judis_chennai/qrydispfree.aspx?filename=11121 |date=20 October 2013 }}
116. ^{{cite web|title=Supreme Court rejects bid by Novartis to patent Glivec|url=http://spicyipindia.blogspot.co.uk/2013/04/supreme-court-rejects-bid-by-novartis.html| archiveurl = https://web.archive.org/web/20131217091420/http://spicyipindia.blogspot.co.uk/2013/04/supreme-court-rejects-bid-by-novartis.html | archivedate = 2013-12-17| deadurl=no}}
117. ^Novartis v UoI, Para 191 {{webarchive |url=https://web.archive.org/web/20130706085312/http://judis.nic.in/supremecourt/imgs1.aspx?filename=40212 |date=6 July 2013 }}
118. ^Novartis v UoI, Para 24-25 {{webarchive |url=https://web.archive.org/web/20130706085312/http://judis.nic.in/supremecourt/imgs1.aspx?filename=40212 |date=6 July 2013 }}
119. ^{{cite web|title=How the Indian judgment will reverberate across the world|url=http://www.firstpost.com/world/how-the-indian-judgment-on-novartis-will-reverberate-across-the-world-684767.html| archiveurl = https://web.archive.org/web/20140118172854/http://www.firstpost.com/world/how-the-indian-judgment-on-novartis-will-reverberate-across-the-world-684767.html | archivedate = 2014-01-18| deadurl=yes}}
120. ^{{cite web|title=Patented drugs must be priced smartly|url=http://articles.economictimes.indiatimes.com/2013-04-03/news/38248707_1_patent-protection-glivec-indian-patent-act| archiveurl = https://web.archive.org/web/20131020222337/http://articles.economictimes.indiatimes.com/2013-04-03/news/38248707_1_patent-protection-glivec-indian-patent-act | archivedate = 2013-10-20| deadurl=yes}}
121. ^Patent with a purpose, Prof. Shamnad Basheer, Indian Express, 3 April 2013 {{webarchive |url=https://web.archive.org/web/20130526074830/http://www.indianexpress.com/news/patent-with-a-purpose/1096741/0 |date=26 May 2013 }}
122. ^Kevin Grogan for PharmaTimes. 27 February 2012 Novartis explains stance over India patent law challenge {{webarchive|url=https://web.archive.org/web/20141216001159/http://www.pharmatimes.com/article/12-02-27/Novartis_explains_stance_over_India_patent_law_challenge.aspx |date=16 December 2014 }}
123. ^Erklärung von Bern. 8 May 2007 Short questions and answers about the court case initiated by Novartis in India {{webarchive |url=https://web.archive.org/web/20131021190810/http://www.evb.ch/en/p25012749.html |date=21 October 2013 }}
124. ^Shift in Novartis Strategy, The Telegraph {{webarchive |url=https://web.archive.org/web/20130511194923/http://www.telegraphindia.com/1130402/jsp/business/story_16736700.jsp#.UV3-TcV49_M |date=11 May 2013 }}
125. ^{{cite web |url=https://www.washingtonpost.com/wp-dyn/content/article/2010/07/14/AR2010071405346.html |title=Novartis Reaches $152.5 Million Sex-Bias Settlement |work= |accessdate=}}
126. ^{{cite web |url=http://www.fda.gov/ICECI/EnforcementActions/WarningLetters/2008/ucm1048118.htm |title=Focalin XR (dexmethylphenidate hydrochloride) extended-release capsules CII |date=2008-09-25 |work=Warning Letters |publisher=US Food and Drug Administration |accessdate=2009-08-05 |archiveurl=https://www.webcitation.org/68JlJjSGb?url=http://www.fda.gov/ICECI/EnforcementActions/WarningLetters/2008/ucm1048118.htm |archivedate=10 June 2012 |deadurl=no |df=dmy }}
127. ^{{cite web |url=http://www.novartis.com/newsroom/media-releases/en/2010/1448151.shtml |title=Novartis Pharmaceuticals Corporation, a US subsidiary of Novartis AG, reaches settlement agreement with US Attorney's Office |publisher=Novartis |date=2010-09-30 |accessdate=2012-01-16 |type=press release |at=Media Releases |archiveurl=https://web.archive.org/web/20131017111251/http://www.novartis.com/newsroom/media-releases/en/2010/1448151.shtml |archivedate=17 October 2013 |deadurl=yes |df=dmy-all }}
128. ^1 {{cite news|last=Wilson |first=Duff |url=https://www.nytimes.com/2010/10/01/health/policy/01novartis.html |title=Novartis Settles Off-Label Marketing Case |publisher=NYTimes.com |date=2010-09-30 |accessdate=2012-01-16}}
129. ^1 2 {{cite news|url=https://www.nytimes.com/2013/04/27/business/us-files-2nd-suit-accusing-novartis-of-kickbacks-to-doctors.html?_r=0 |title=U.S. Sues Novartis Again, Accusing It of Kickbacks |publisher=The New York Times |date=2013-04-26 |accessdate=2013-04-27}}
130. ^1 {{cite web|url=http://www.justice.gov/opa/pr/2013/April/13-civ-481.html |title=United States Files Complaint Against Novartis Pharmaceuticals Corp. for Allegedly Paying Kickbacks to Doctors in Exchange for Prescribing Its Drugs |publisher=The United States Department of Justice |date=2013-04-26 |accessdate=2013-04-26| archiveurl = https://web.archive.org/web/20140413062711/http://www.justice.gov/opa/pr/2013/April/13-civ-481.html | archivedate = 2014-04-13| deadurl=no}}
131. ^Andrew Pollack for The New York Times. 28 April 2011 [https://www.nytimes.com/2011/04/29/business/29eye.html?_r=0 Cheaper Drug to Treat Eye Disease Is Effective]
132. ^1 {{cite news|last=Jeffreys |first=Branwen |url=https://www.bbc.co.uk/news/health-17956425 |title=Using Avastin for eye condition wet AMD 'could save NHS £84m' |publisher=bbc.com |date=2012-05-06 |accessdate=2012-05-06| archiveurl = https://web.archive.org/web/20131106060449/http://www.bbc.co.uk/news/health-17956425 | archivedate = 2013-11-06| deadurl=no}}
133. ^{{Citation|last=Copley |first=Caroline |first2=Ben |last2=Hirschler |editor=Potter, Mark |publication-date=24 April 2012 |title=Novartis challenges UK Avastin use in eye disease |publisher=Reuters |url=https://www.reuters.com/article/2012/04/24/us-novartis-britain-idUSBRE83N0GM20120424 |accessdate=2012-04-29 |deadurl=yes |archiveurl=https://web.archive.org/web/20130522203804/https://www.reuters.com/article/2012/04/24/us-novartis-britain-idUSBRE83N0GM20120424 |archivedate=22 May 2013 |df=dmy }}
134. ^Ben Adams for Pharmafile. 26 July 2012 Lucentis price cut ends PCT-Novartis dispute {{webarchive |url=https://web.archive.org/web/20131019124934/http://www.pharmafile.com/news/173606/lucentis-price-cut-ends-pct-novartis-dispute |date=19 October 2013 }}
135. ^Ben Adams for Pharma Times. 3 October 2012. Novartis to drop legal case against NHS body {{webarchive |url=https://web.archive.org/web/20131019132110/http://www.pharmatimes.com/Article/12-10-03/Novartis_to_drop_legal_case_against_NHS_body.aspx |date=19 October 2013 }}
136. ^1 Kana Inagaki for The Wall Street Journal. 11 August 2013 [https://online.wsj.com/news/articles/SB10001424127887323838204579000403952581982 Novartis Hit by Scandal Over Japanese Drug Studies: Probes Uncover Altered Research Data; Swiss Giant Stands by Heart Medicine Diovan] {{webarchive |url=https://web.archive.org/web/20131013192537/http://online.wsj.com/news/articles/SB10001424127887323838204579000403952581982 |date=13 October 2013 }}
137. ^Kana Inagaki for The Wall Street Journal. 12 August 2013. [https://blogs.wsj.com/japanrealtime/2013/08/12/novartis-drug-studies-in-japan-tracing-back-the-questions/ Novartis Drug Studies in Japan–Tracing Back the Questions] {{webarchive |url=https://web.archive.org/web/20131018005314/https://blogs.wsj.com/japanrealtime/2013/08/12/novartis-drug-studies-in-japan-tracing-back-the-questions/ |date=18 October 2013 }}
138. ^{{cite news | url= https://online.wsj.com/news/articles/SB10001424052702303933104579307443220022558 |title= Japan Criminal Probe Could Spell More Trouble for Novartis |publisher=The Wall Street Journal |date=10 January 2014 | archiveurl = https://web.archive.org/web/20140302153955/http://online.wsj.com/news/articles/SB10001424052702303933104579307443220022558 | archivedate = 2014-03-02| deadurl=no}}
139. ^{{cite news|title=Data manipulation by staff gets Novartis into legal mess in Japan|url=http://www.japanherald.com/index.php/sid/223435459/scat/c4f2dd8ca8c78044/ht/Data-manipulation-by-staff-gets-Novartis-into-legal-mess-in-Japan|accessdate=2014-07-02|publisher=Japan Herald|archive-url=https://web.archive.org/web/20140829181210/http://www.japanherald.com/index.php/sid/223435459/scat/c4f2dd8ca8c78044/ht/Data-manipulation-by-staff-gets-Novartis-into-legal-mess-in-Japan|archive-date=29 August 2014|dead-url=yes|df=dmy-all}}
140. ^1 {{Cite web|url=http://greece.greekreporter.com/2018/02/06/greek-officials-hit-back-at-novartis-bribery-allegations/|title=Greek Officials Hit Back at Novartis Bribery Allegations {{!}} GreekReporter.com|website=greece.greekreporter.com|language=en-US|access-date=2018-02-07}}
141. ^{{Cite web|url=https://www.fiercepharma.com/legal/greek-officials-ban-novartis-manager-from-leaving-country-amid-widening-bribery-probe-report|title=Greek officials ban Novartis manager from leaving the country amid widening bribery probe: report {{!}} FiercePharma|website=www.fiercepharma.com|language=en|access-date=2018-02-07}}
142. ^{{Cite news|url=https://www.nytimes.com/aponline/2018/02/05/world/europe/ap-eu-greece-pharma-scandal.html|title=Greek Govt Alleges Official Ties to Drug Bribery Scandal|last=Press|first=The Associated|date=2018-02-05|work=The New York Times|access-date=2018-02-07|language=en-US|issn=0362-4331}}
143. ^{{Cite web|url=http://www.dw.com/en/novartis-under-investigation-for-bribery-in-greece/a-37230558|title=Novartis under investigation for bribery in Greece {{!}} Europe{{!}} News and current affairs from around the continent {{!}} DW {{!}} 22.01.2017|last=(www.dw.com)|first=Deutsche Welle|website=DW.COM|language=en|access-date=2018-02-07}}
144. ^{{Cite web|url=https://www.ft.com/content/61e2cca8-5363-11e8-b3ee-41e0209208ec|title=Novartis admits $1.2m in payments to Trump lawyer|accessdate=2018-05-10|publisher=Financial Times}}
145. ^Emma Court (16 July 2018.) [https://www.marketwatch.com/story/novartis-had-longer-and-more-detailed-relationship-with-trump-lawyer-michael-cohen-senate-report-finds-2018-07-13 Novartis had ‘longer and more detailed’ relationship with Trump lawyer Michael Cohen, Senate report finds]. marketwatch.com. Retrieved 21 August 2018.
146. ^[https://www.finance.senate.gov/imo/media/doc/REPORT%20White%20House%20Access%20for%20Sale%20Michael%20Cohen%20and%20Novartis.pdf White House Access for Sale: Michael Cohen, Novartis and the bid to sell access to the Trump administration]. Retrieved 21 August 2018.

Further reading

  • {{Cite web|url = http://www.mckinsey.com/insights/leading_in_the_21st_century/novartis_on_digitizing_medicine_in_an_aging_world|title = Novartis on digitizing medicine in an aging world|date = June 2015|accessdate = 2015-08-16|website = Insights & Publications|publisher = McKinsey & Company|last = Kirkland|first = Rik|last2 = Jimenez|first2 = Joseph|type = Interview}}

External links

{{Commons category|Novartis}}
  • {{official website|http://www.novartis.com/}}
{{Pharmaceutical companies of Switzerland}}{{Swiss Market Index companies}}{{Portal bar|Companies|Switzerland}}{{Authority control}}{{DEFAULTSORT:Novartis}}

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