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词条 23S rRNA (adenine2503-C2,C8)-dimethyltransferase
释义

  1. References

  2. External links

{{Infobox enzyme
| Name = 23S rRNA (adenine2503-C2,C8)-dimethyltransferase
| EC_number = 2.1.1.194
| CAS_number = 39369-30-7
| IUBMB_EC_number = 2/1/1/194
| GO_code =
| image =
| width =
| caption =
}}23S rRNA (adenine2503-C2,C8)-dimethyltransferase ({{EC number|2.1.1.194}}, Cfr, Cfr methyltransferase, Cfr rRNA methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (adenine2503-C2,C8)-dimethyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction

2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA 2 S-adenosyl-L-homocysteine + 2,8-dimethyladenine2503 in 23S rRNA

This enzyme contains an [4Fe-S] cluster.

References

1. ^{{cite journal | vauthors = Yan F, LaMarre JM, Röhrich R, Wiesner J, Jomaa H, Mankin AS, Fujimori DG | title = RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA | journal = Journal of the American Chemical Society | volume = 132 | issue = 11 | pages = 3953–64 | date = March 2010 | pmid = 20184321 | pmc = 2859901 | doi = 10.1021/ja910850y }}
2. ^{{cite journal | vauthors = Giessing AM, Jensen SS, Rasmussen A, Hansen LH, Gondela A, Long K, Vester B, Kirpekar F | title = Identification of 8-methyladenosine as the modification catalyzed by the radical SAM methyltransferase Cfr that confers antibiotic resistance in bacteria | journal = RNA | volume = 15 | issue = 2 | pages = 327–36 | date = February 2009 | pmid = 19144912 | pmc = 2648713 | doi = 10.1261/rna.1371409 }}
3. ^{{cite journal | vauthors = Kaminska KH, Purta E, Hansen LH, Bujnicki JM, Vester B, Long KS | title = Insights into the structure, function and evolution of the radical-SAM 23S rRNA methyltransferase Cfr that confers antibiotic resistance in bacteria | journal = Nucleic Acids Research | volume = 38 | issue = 5 | pages = 1652–63 | date = March 2010 | pmid = 20007606 | pmc = 2836569 | doi = 10.1093/nar/gkp1142 }}

External links

  • {{MeshName|23S+rRNA+(adenine2503-C2,C8)-dimethyltransferase}}
{{One carbon transferases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}

1 : EC 2.1.1

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